CellValidating net

ADO.Net is kind of set up so that you don't need to worry about this stuff if your physical database design matches your logical design. RE: datagrid cell validating RiverGuy (Programmer) 17 Nov 08 12:52 Right now I'm using CellValidating, CellValidated, and CellEndEdit. But I think your method is the best. If you can provide and example it would help a lot. – shenk Jun 7 '15 at 0:55 'CellValidating event is that you can stop the user from leaving a cell' which also prevents user from closing the Form. Sql - Validate Datagridview Using The Cellvalidating Event Jun 5, 2009 I have a datagridview that I would like to validate using the cellvalidating event. however as the user doesnt navigate between cells or rows in the datagridview. just enters data in a cell in the datagridview and then clicks a save button the cellvalidating event doesnt get ... CodeProject, 503-250 Ferrand Drive Toronto Ontario, M3C 3G8 Canada +1 416-849-8900 x 100 Inside the CellValidating event you set the Tag property of the Timer with the Row Index, the Column Index and the cell value that you want to assign to the cell, and finally you activate the Timer. When the timer ticks, the validation process has finished, so the Timer_Tick event get the Row index, the column index and the text value and ... Using Vb.Net 2005, Unbound DataGridViewer with 2 (two) columns ('CheckNum' Index 0; 'ClearDate' Index 1). I would like to be able to validate the cells and force the user to put correct values in it. I tried CellValidating, but it could not pull the values in to validate. Entering '123' in the field should be valid.

Top 15 Coupon Websites to Save a Ton of Money

2020.10.22 19:33 Nahedmir Top 15 Coupon Websites to Save a Ton of Money

Top 15 Coupon Websites to Save a Ton of Money
Shopping is a lively and enjoyable activity. People spend their time shopping with friends and loved ones after a long hectic day. People love to go shopping as they keep them fresh and excited. Shopping is full of fun and enjoyment. Online shopping gains popularity in recent times and becomes trendy. Online shopping saves time and money for people and encourages them to do more shopping. Many coupon websites are working swiftly on the internet to help the customers shop at affordable prices. The advertising sites work day and night with dedication and care for the relief of the customers worldwide. Lots of discounted deals and offers are present on these sites. People use these deals to buy the best possible deals for them. Everyone can get these deals while shopping. The coupon sites are incredibly beneficial, and people love to go shopping with them. We will discuss the top 15 coupon websites to save a ton of money in this article.

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As we know, many online stores are offering special discounts and delivering to customers. The sites are working hard and providing the best services to online shoppers worldwide. Dontpayfull is an online platform that has multiple goods and stocks readily available to customers. You can buy your ideal goods from top brands at reasonable prices. Dontpayfull.com offers its customers excellent and valuable deals that are attractive and can save you plenty of money. You can explore the different brands and products on the site and search for yourself superior value. Always use your coupon code wisely and grab the deal accordingly. Happy shopping, and don't pay full.

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People love to go shopping, and they love it even more if they get a discount on goods. Lots of sites are offering customers to shop and save money online. Givingassistant.org is an advertising site that is working with enormous brands and goods. It has a vast category that has tons of goods and items. You can also book air tickets at a discount. You will observe everything about the website's daily use, and you can save plenty of money on them. The coupons are valid and work fine without any disturbance. Always use the relevant agreement for yourself and utilize it. Grab your ideal goods and enjoy the savings at Givingassistant.org.

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Bradsdeals.com
Bradsdeals.com is working effectively over the past years to assist its thousands of customers every day. People love to shop at this platform, and it saves them money. It has a wide range of international goods that are readily accessible to everyone. The site is offering an opportunity for its customers to shop the goods at reasonable prices. It has a wide variety of Men, Women, and Children goods that are new and stylish. You can explore tons of coupons on the main page of the website. Explore the top deals section on the site to view the relevant and ideal deal for yourself. Use the promo codes while shopping and enjoy the savings with Bradsdeals.com.

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GoodShop.com
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DealCatcher.com
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Savings.com
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CouponChief.com
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submitted by Nahedmir to u/Nahedmir [link] [comments]


2020.10.19 07:00 coRvid_ice_elation COVID19 PCR Tests are Scientifically Meaningless

https://archive.is/R4gPW
Though the whole world relies on RT-PCR to “diagnose” Sars-Cov-2 infection, the science is clear: they are not fit for purpose
Torsten Engelbrecht and Konstantin Demeter
Lockdowns and hygienic measures around the world are based on numbers of cases and mortality rates created by the so-called SARS-CoV-2 RT-PCR tests used to identify “positive” patients, whereby “positive” is usually equated with “infected.”But looking closely at the facts, the conclusion is that these PCR tests are meaningless as a diagnostic tool to determine an alleged infection by a supposedly new virus called SARS-CoV-2.

UNFOUNDED “TEST, TEST, TEST,…” MANTRA

At the media briefing on COVID-19 on March 16, 2020, the WHO Director General Dr Tedros Adhanom Ghebreyesus said:
We have a simple message for all countries: test, test, test.”
The message was spread through headlines around the world, for instance by Reuters and the BBC.Still on the 3 of May, the moderator of the heute journal — one of the most important news magazines on German television— was passing the mantra of the corona dogma on to his audience with the admonishing words:
Test, test, test—that is the credo at the moment, and it is the only way to really understand how much the coronavirus is spreading.”
This indicates that the belief in the validity of the PCR tests is so strong that it equals a religion that tolerates virtually no contradiction.But it is well known that religions are about faith and not about scientific facts. And as Walter Lippmann, the two-time Pulitzer Prize winner and perhaps the most influential journalist of the 20th century said: “Where all think alike, no one thinks very much.”So to start, it is very remarkable that Kary Mullis himself, the inventor of the Polymerase Chain Reaction (PCR) technology, did not think alike. His invention got him the Nobel prize in chemistry in 1993.Unfortunately, Mullis passed away last year at the age of 74, but there is no doubt that the biochemist regarded the PCR as inappropriate to detect a viral infection.The reason is that the intended use of the PCR was, and still is, to apply it as a manufacturing technique, being able to replicate DNA sequences millions and billions of times, and not as a diagnostic tool to detect viruses.How declaring virus pandemics based on PCR tests can end in disaster was described by Gina Kolata in her 2007 New York Times article Faith in Quick Test Leads to Epidemic That Wasn’t.

LACK OF A VALID GOLD STANDARD

Moreover, it is worth mentioning that the PCR tests used to identify so-called COVID-19 patients presumably infected by what is called SARS-CoV-2 do not have a valid gold standard to compare them with.This is a fundamental point. Tests need to be evaluated to determine their preciseness — strictly speaking their “sensitivity”[1] and “specificity” — by comparison with a “gold standard,” meaning the most accurate method available.As an example, for a pregnancy test the gold standard would be the pregnancy itself. But as Australian infectious diseases specialist Sanjaya Senanayake, for example, stated in an ABC TV interview in an answer to the question “How accurate is the [COVID-19] testing?”:
If we had a new test for picking up [the bacterium] golden staph in blood, we’ve already got blood cultures, that’s our gold standard we’ve been using for decades, and we could match this new test against that. But for COVID-19 we don’t have a gold standard test.”
Jessica C. Watson from Bristol University confirms this. In her paper “Interpreting a COVID-19 test result”, published recently in The British Medical Journal, she writes that there is a “lack of such a clear-cut ‘gold-standard’ for COVID-19 testing.”But instead of classifying the tests as unsuitable for SARS-CoV-2 detection and COVID-19 diagnosis, or instead of pointing out that only a virus, proven through isolation and purification, can be a solid gold standard, Watson claims in all seriousness that, “pragmatically” COVID-19 diagnosis itself, remarkably including PCR testing itself, “may be the best available ‘gold standard’.” But this is not scientifically sound.Apart from the fact that it is downright absurd to take the PCR test itself as part of the gold standard to evaluate the PCR test, there are no distinctive specific symptoms for COVID-19, as even people such as Thomas Löscher, former head of the Department of Infection and Tropical Medicine at the University of Munich and member of the Federal Association of German Internists, conceded to us[2].And if there are no distinctive specific symptoms for COVID-19, COVID-19 diagnosis — contrary to Watson’s statement — cannot be suitable for serving as a valid gold standard.In addition, “experts” such as Watson overlook the fact that only virus isolation, i.e. an unequivocal virus proof, can be the gold standard.That is why I asked Watson how COVID-19 diagnosis “may be the best available gold standard,” if there are no distinctive specific symptoms for COVID-19, and also whether the virus itself, that is virus isolation, wouldn’t be the best available/possible gold standard. But she hasn’t answered these questions yet – despite multiple requests. And she has not yet responded to our rapid response post on her article in which we address exactly the same points, either, though she wrote us on June 2nd: “I will try to post a reply later this week when I have a chance.”

NO PROOF FOR THE RNA BEING OF VIRAL ORIGIN

Now the question is: What is required first for virus isolation/proof? We need to know where the RNA for which the PCR tests are calibrated comes from.As textbooks (e.g., White/Fenner. Medical Virology, 1986, p. 9) as well as leading virus researchers such as Luc Montagnier or Dominic Dwyer state, particle purification — i.e. the separation of an object from everything else that is not that object, as for instance Nobel laureate Marie Curie purified 100 mg of radium chloride in 1898 by extracting it from tons of pitchblende — is an essential pre-requisite for proving the existence of a virus, and thus to prove that the RNA from the particle in question comes from a new virus.The reason for this is that PCR is extremely sensitive, which means it can detect even the smallest pieces of DNA or RNA — but it cannot determine where these particles came from. That has to be determined beforehand.And because the PCR tests are calibrated for gene sequences (in this case RNA sequences because SARS-CoV-2 is believed to be a RNA virus), we have to know that these gene snippets are part of the looked-for virus. And to know that, correct isolation and purification of the presumed virus has to be executed.Hence, we have asked the science teams of the relevant papers which are referred to in the context of SARS-CoV-2 for proof whether the electron-microscopic shots depicted in their in vitro experiments show purified viruses.But not a single team could answer that question with “yes” — and NB., nobody said purification was not a necessary step. We only got answers like “No, we did not obtain an electron micrograph showing the degree of purification” (see below).We asked several study authors “Do your electron micrographs show the purified virus?”, they gave the following responses:Study 1: Leo L. M. Poon; Malik Peiris. “Emergence of a novel human coronavirus threatening human health” Nature Medicine, March 2020 Replying Author: Malik Peiris Date: May 12, 2020 Answer: “The image is the virus budding from an infected cell. It is not purified virus.”Study 2: Myung-Guk Han et al. “Identification of Coronavirus Isolated from a Patient in Korea with COVID-19”, Osong Public Health and Research Perspectives, February 2020 Replying Author: Myung-Guk Han Date: May 6, 2020 Answer: “We could not estimate the degree of purification because we do not purify and concentrate the virus cultured in cells.”Study 3: Wan Beom Park et al. “Virus Isolation from the First Patient with SARS-CoV-2 in Korea”, Journal of Korean Medical Science, February 24, 2020 Replying Author: Wan Beom Park Date: March 19, 2020 Answer: “We did not obtain an electron micrograph showing the degree of purification.”Study 4: Na Zhu et al., “A Novel Coronavirus from Patients with Pneumonia in China”, 2019, New England Journal of Medicine, February 20, 2020 Replying Author: Wenjie Tan Date: March 18, 2020 Answer: “[We show] an image of sedimented virus particles, not purified ones.”Regarding the mentioned papers it is clear that what is shown in the electron micrographs (EMs) is the end result of the experiment, meaning there is no other result that they could have made EMs from.That is to say, if the authors of these studies concede that their published EMs do not show purified particles, then they definitely do not possess purified particles claimed to be viral. (In this context, it has to be remarked that some researchers use the term “isolation” in their papers, but the procedures described therein do not represent a proper isolation (purification) process. Consequently, in this context the term “isolation” is misused).Thus, the authors of four of the principal, early 2020 papers claiming discovery of a new coronavirus concede they had no proof that the origin of the virus genome was viral-like particles or cellular debris, pure or impure, or particles of any kind. In other words, the existence of SARS-CoV-2 RNA is based on faith, not fact.We have also contacted Dr Charles Calisher, who is a seasoned virologist. In 2001, Science published an “impassioned plea…to the younger generation” from several veteran virologists, among them Calisher, saying that:
[modern virus detection methods like] sleek polymerase chain reaction […] tell little or nothing about how a virus multiplies, which animals carry it, [or] how it makes people sick. [It is] like trying to say whether somebody has bad breath by looking at his fingerprint.”[3]
And that’s why we asked Dr Calisher whether he knows one single paper in which SARS-CoV-2 has been isolated and finally really purified. His answer:
I know of no such a publication. I have kept an eye out for one.”[4]
This actually means that one cannot conclude that the RNA gene sequences, which the scientists took from the tissue samples prepared in the mentioned in vitro trials and for which the PCR tests are finally being “calibrated,” belong to a specific virus — in this case SARS-CoV-2.
In addition, there is no scientific proof that those RNA sequences are the causative agent of what is called COVID-19.In order to establish a causal connection, one way or the other, i.e. beyond virus isolation and purification, it would have been absolutely necessary to carry out an experiment that satisfies the four Koch’s postulates. But there is no such experiment, as Amory Devereux and Rosemary Frei recently revealed for OffGuardian.The necessity to fulfill these postulates regarding SARS-CoV-2 is demonstrated not least by the fact that attempts have been made to fulfill them. But even researchers claiming they have done it, in reality, did not succeed.One example is a study published in Nature on May 7. This trial, besides other procedures which render the study invalid, did not meet any of the postulates.For instance, the alleged “infected” laboratory mice did not show any relevant clinical symptoms clearly attributable to pneumonia, which according to the third postulate should actually occur if a dangerous and potentially deadly virus was really at work there. And the slight bristles and weight loss, which were observed temporarily in the animals are negligible, not only because they could have been caused by the procedure itself, but also because the weight went back to normal again.Also, no animal died except those they killed to perform the autopsies. And let’s not forget: These experiments should have been done before developing a test, which is not the case.Revealingly, none of the leading German representatives of the official theory about SARS-Cov-2/COVID-19 — the Robert Koch-Institute (RKI), Alexander S. Kekulé (University of Halle), Hartmut Hengel and Ralf Bartenschlager (German Society for Virology), the aforementioned Thomas Löscher, Ulrich Dirnagl (Charité Berlin) or Georg Bornkamm (virologist and professor emeritus at the Helmholtz-Zentrum Munich) — could answer the following question I have sent them:If the particles that are claimed to be to be SARS-CoV-2 have not been purified, how do you want to be sure that the RNA gene sequences of these particles belong to a specific new virus?Particularly, if there are studies showing that substances such as antibiotics that are added to the test tubes in the in vitro experiments carried out for virus detection can “stress” the cell culture in a way that new gene sequences are being formed that were not previously detectable — an aspect that Nobel laureate Barbara McClintock already drew attention to in her Nobel Lecture back in 1983.It should not go unmentioned that we finally got the Charité – the employer of Christian Drosten, Germany’s most influential virologist in respect of COVID-19, advisor to the German government and co-developer of the PCR test which was the first to be “accepted” (not validated!) by the WHO worldwide – to answer questions on the topic.But we didn’t get answers until June 18, 2020, after months of non-response. In the end, we achieved it only with the help of Berlin lawyer Viviane Fischer.Regarding our question “Has the Charité convinced itself that appropriate particle purification was carried out?,” the Charité concedes that they didn’t use purified particles.And although they claim “virologists at the Charité are sure that they are testing for the virus,” in their paper (Corman et al.) they state:
RNA was extracted from clinical samples with the MagNA Pure 96 system (Roche, Penzberg, Germany) and from cell culture supernatants with the viral RNA mini kit (QIAGEN, Hilden, Germany),”
Which means they just assumed the RNA was viral.Incidentally, the Corman et al. paper, published on January 23, 2020 didn’t even go through a proper peer review process, nor were the procedures outlined therein accompanied by controls — although it is only through these two things that scientific work becomes really solid.

IRRATIONAL TEST RESULTS

It is also certain that we cannot know the false positive rate of the PCR tests without widespread testing of people who certainly do not have the virus, proven by a method which is independent of the test (having a solid gold standard).Therefore, it is hardly surprising that there are several papers illustrating irrational test results.For example, already in February the health authority in China’s Guangdong province reported that people have fully recovered from illness blamed on COVID-19, started to test “negative,” and then tested “positive” again.A month later, a paper published in the Journal of Medical Virology showed that 29 out of 610 patients at a hospital in Wuhan had 3 to 6 test results that flipped between “negative”, “positive” and “dubious”.A third example is a study from Singapore in which tests were carried out almost daily on 18 patients and the majority went from “positive” to “negative” back to “positive” at least once, and up to five times in one patient.Even Wang Chen, president of the Chinese Academy of Medical Sciences, conceded in February that the PCR tests are “only 30 to 50 per cent accurate”; while Sin Hang Lee from the Milford Molecular Diagnostics Laboratory sent a letter to the WHO’s coronavirus response team and to Anthony S. Fauci on March 22, 2020, saying that:
It has been widely reported in the social media that the RT-qPCR [Reverse Transcriptase quantitative PCR] test kits used to detect SARSCoV-2 RNA in human specimens are generating many false positive results and are not sensitive enough to detect some real positive cases.”
In other words, even if we theoretically assume that these PCR tests can really detect a viral infection, the tests would be practically worthless, and would only cause an unfounded scare among the “positive” people tested.This becomes also evident considering the positive predictive value (PPV).The PPV indicates the probability that a person with a positive test result is truly “positive” (ie. has the supposed virus), and it depends on two factors: the prevalence of the virus in the general population and the specificity of the test, that is the percentage of people without disease in whom the test is correctly “negative” (a test with a specificity of 95% incorrectly gives a positive result in 5 out of 100 non-infected people).With the same specificity, the higher the prevalence, the higher the PPV.In this context, on June 12 2020, the journal Deutsches Ärzteblatt published an article in which the PPV has been calculated with three different prevalence scenarios.The results must, of course, be viewed very critically, first because it is not possible to calculate the specificity without a solid gold standard, as outlined, and second because the calculations in the article are based on the specificity determined in the study by Jessica Watson, which is potentially worthless, as also mentioned.But if you abstract from it, assuming that the underlying specificity of 95% is correct and that we know the prevalence, even the mainstream medical journal Deutsches Ärzteblatt reports that the so-called SARS-CoV-2 RT-PCR tests may have “a shockingly low” PPV.In one of the three scenarios, figuring with an assumed prevalence of 3%, the PPV was only 30 percent, which means that 70 percent of the people tested “positive” are not “positive” at all. Yet “they are prescribed quarantine,” as even the Ärzteblatt notes critically.In a second scenario of the journal’s article, a prevalence of rate of 20 percent is assumed. In this case they generate a PPV of 78 percent, meaning that 22 percent of the “positive” tests are false “positives.”That would mean: If we take the around 9 million people who are currently considered “positive” worldwide — supposing that the true “positives” really have a viral infection — we would get almost 2 million false “positives.”All this fits with the fact that the CDC and the FDA, for instance, concede in their files that the so-called “SARS-CoV-2 RT-PCR tests” are not suitable for SARS-CoV-2 diagnosis.In the “CDC 2019-Novel Coronavirus (2019-nCoV) Real-Time RT-PCR Diagnostic Panel“ file from March 30, 2020, for example, it says:
Detection of viral RNA may not indicate the presence of infectious virus or that 2019-nCoV is the causative agent for clinical symptoms”
And:
This test cannot rule out diseases caused by other bacterial or viral pathogens.”
And the FDA admits that:
positive results […] do not rule out bacterial infection or co-infection with other viruses. The agent detected may not be the definite cause of disease.”
Remarkably, in the instruction manuals of PCR tests we can also read that they are not intended as a diagnostic test, as for instance in those by Altona Diagnostics and Creative Diagnostics[5].To quote another one, in the product announcement of the LightMix Modular Assays produced by TIB Molbiol — which were developed using the Corman et al. protocol — and distributed by Roche we can read:
These assays are not intended for use as an aid in the diagnosis of coronavirus infection”
see comment below for MORE
submitted by coRvid_ice_elation to u/coRvid_ice_elation [link] [comments]


2020.10.14 02:08 pfeifer1982HC Cynata Therapeutic’s Cymerus™ iPSC-MSC Manufacturing Platform

Cynata Therapeutic’s Cymerus™ iPSC-MSC Manufacturing Platform
What is Cymerus?
Unlike current conventional MSC manufacturing processes applied by other companies in this sector, Cynata Therapeutics (Cynata) took a different approach:
  1. evaluating possible shortcomings / bottlenecks of existing processes on their way to at-scale manufacturing down the track (past Phase 3 clinical trials),
  2. looking for an alternative,
  3. creating a platform,
  4. testing it01107-X/fulltext),
  5. validating its at-scale manufacturing capability,
  6. then taking your product/s to the clinic.
Cynata's Cymerus™ manufacturing platform utilises induced pluripotent stem cells (adult cells reprogrammed to an embryonic stem cell-like state, maintaining the essential properties of embryonic stem cells, but without the ethical and legal concerns surrounding them).
These induced pluripotent stem cells (iPSCs) are turned into a (mesoderm-derived) precursor cell known as mesenchymoangioblast (MCA), before generating the final Cymerus™ iPSC-MSCs.
Source: Cynata Investor Presentation 14 August 2020
The manufacturing process consists of three stages:
  1. iPSC banking,
  2. iPSC expansion and differentiation to MSCs to freeze and intermediate bank and
  3. MSC expansion and formulation of final clinical product.
The above outlined cutting-edge technology eventually resulted in the world's first clinical trial of an allogeneic iPSC-derived MSC product, evaluating the safety and efficacy of Cynata's lead product CYP-001 for the treatment of 15 patients with steroid-resistent acute graft-versus-host disease (SR-aGvHD) with very encouraging results:
"The Phase 1 clinical trial enrolled 15 patients with steroid-resistant acute GvHD. The primary evaluation at Day 100 revealed highly promising safety and efficacy results, as announced on 18 December 2018. By Day 100, the Complete Response and Overall Response rates were 53% and 87% respectively, and overall survival was at least 87%.
Participants who completed the Primary Evaluation Period then continued to a follow-up period for up to two years after the initial dose, which has now been completed.
The overall survival rate after two years was 60% (9/15 patients), which compares favourably with previously published outcomes. An overall survival rate of just 17% after two years has been reported in patients with steroid-resistant acute GvHD who received standard of care treatment.1 Furthermore, a recently published review article summarised numerous studies with bone marrow and adipose tissue derived MSCs in patients with steroid-resistant acute GvHD. Six of the studies reviewed reported two year survival in MSC-treated patients, which ranged from 16.6% to 40%.2 Similarly, in another recently published Phase 3 trial of an investigational drug (ruxolitinib) in patients with steroid-resistant acute GvHD, overall survival after 12 months was 38%, while there were insufficient surviving patients remaining on study to calculate the survival rate at later timepoints.3 The results of Cynata’s trial illustrate the significant potential of CYP-001 as a new treatment option for GvHD."
In order to further validate its Cymerus-MSCs by showing that the cells have similar or superior functionality to native, donor-derived MSCs, Cynata is building a large catalogue of pre-clinical data covering numerous diseases:
Source: Cynata Investor Presentation 14 August 2020

A look under the hood
Based on the existing banking strategy, approximately 9 × 10^4 vials, each containing 1 × 10^6 iPSCs, can be generated from a single iPSC line. At the current processing scale, a single vial of 1 × 10^6 iPSCs is capable of giving rise to 3.2 × 10^10 MSCs on average, while the entire iPSC bank has the capacity to generate 2.9 × 10^15 MSCs, or 29 million clinical doses (each containing 1 × 10^8 MSCs).
Compared to other companies that have stated to be capable of producing enough clinical doses to treat between 500 to 20,000 patients from the starting material from just one donor, Cynata's Cymerus™ platform would allow to overcome a number of important limitations, including:
  • dependence upon donors
  • variability between donors
  • the relative scarcity of MSCs in adult tissue
  • the low proliferative capacity of adult stem cells
  • loss of potency and reduced efficacy associated with extensive MSC culture expansion (in an effort to maximise the number of MSCs from each donation).
Conversely, since iPSCs can proliferate indefinitely, and MCAs themselves can expand into extremely large quantities of MSCs, Cynata expects to be able to manufacture all of the cells that it will ever need from a single Master Cell Bank of iPSCs – derived from a single donor.
More information on the process can be found here.

iPSC = Cancer?
Cynata has also thought of a way to avoid the teratoma formation risk that is associated with (undifferentiated) iPSCs in vivo by incorporating the following steps to the manufacturing process:
  1. after the induction of mesoderm, cells were cultured in a single-cell suspension in semisolid medium, which does not support iPSC survival;
  2. cells were passed through a mesh filtration step, which eliminates small clumps of undifferentiated iPSCs; and
  3. iPSC-derived MSCs were expanded in adherent cell culture conditions, which do not support survival or expansion of undifferentiated iPSCs.
More information can be found here.

Where does the iPSC starting material come from?
The iPSC starting material is currently being provided by FujiFilm Cellular Dynamics (which was used in Cynata's World-First clinical trial of an allogeneic iPSC-derived therapy). The original license agreement was entered into with Cellular Dynamics back in September 2014. Cellular Dynamics International, Inc. (CDI). CDI, the world's largest producer of cellular tools for drug discovery and safety derived from iPSCs, at the time, was the first company outside of Japan that iPS Academia Japan, Inc. has granted licensing to the Kyoto University iPSC patent portfolio arising out of the work of Dr. Shinya Yamanaka, M.D., Ph.D., Center for iPS Cell Research and Application (CiRA), Kyoto University and Dr. James A. Thomson, Ph.D.), University of Wisconsin-Madison. Professor James Thomson and his team at the University of Wisconsin - Madison, including Professor Igor Slukvin (one of the founders of Cynata) were one of two independent research groups that first reported the creation of iPSCs from human cells (along with Professor Shinya Yamanaka et al, at Kyoto University, Japan). On 30 March 2015 however, CDI was acquired by FujiFilm for an amount of US$307 million, representing a premium of 108% to CDI’s closing price on 27 March 2015.FujiFilm now also happens to be the licensee of Cynata's lead product CYP-001 in GvHD.Having said that, Cynata's Cymerus™ iPSC-MSC platform could also be utilised using iPSC starting material from other companies, which also makes it a very lucrative approach for companies that already have access to their own iPSC line and/or are looking into genome editing.

It's all about the patents
The iPSC step is covered under the license agreement between iPS Academia and (now) FujiFilm Cellular Dynamic (FCDI).
A license agreement with the Wisconsin Alumni Research Foundation (WARF), which is the licensing and patenting atm of the University of Wisconson, Madison, where Professor Igor Slukvin MD, PhD, has developed this technology, granted Cynata world-wide exclusive rights to certain patented (one granted patent and certain patent applications) IP forming part of the Cynata Technology comprised in Appendix B-2 ["Generation of clonal mesenchymal progenitors and mesenchymal stem cell lines under serum-free conditions"] the License Agreement as described in Section 8 in relation to making, using, selling, importing, and offering for sale certain products for certain therapeutic and diagnostic uses [...].
The original Cynata Technology has since been further developed, with parts of the original process being eliminated and replaced by licensed progressive improvements. This commercially viable and improved Cymerus™ manufacturing platform, now capable of generating MSCs with superior performance compared to the original process, is covered by an Estate of patents both worldwide exclusively and non-exclusively licensed to Cynata as well as patents fully owned by Cynata.
For example, while early IP covered production of MCAs from PSCs using OP9 Feeder cells changed to MSCs to MCAs (still using mouse feeder layers), there is now exclusively licenced IP covering production of MSCs from MCAs and MCAs from PSCs under defined conditions in the absence of non-human components (Tenascin-C). One of them being this one here: "Methods and materials for hematoendothelial differentiation of human pluripotent stem cells under defined conditions" (patent family: US14206778 & patent application US20140273211A1), which is as per ASX announcement dated 7 December 2017 owned by WARF and to Cynata.
Cynata filed for a patent (amongst others) citing this one, called "Colony forming medium and use thereof", inventors being Igor Slukvin, Gene Uenishi, Derek Hei and Diana Drier.
This patent Estate is best described by saying that the core technology has been licensed from WARF with own patents (not licensed from WARF) around it. Whilst the core patent 7,615,374 has an anticipated expiration of 1 Februart 2028, other patents covering improvements that, unless being utilised won't result in the same final Cymerus-MSC product, have anticipated expiration as far as 24 January 2035.
There is a great example on here covering this very topic in regards to mobile phones used today, stating the following:"This is particularly important when it comes to filing new patent applications, as each new ‘inventive step’ can be patented in its own right, allowing many different aspects of an invention to be protected. Securing multiple patents can also mean that even if an earlier patent expires, the latest developments added to the product will continue to be safeguarded from being plagiarised."
Regarding a very vague, therefore in my opinion a last resort desperate attempt to start a "composition of matter" argument, I would strongly recommend to check out the following links:
Although investors of other stem cell companies regulalry refer to possible patent infringements due to their belief that one company can actually "own" MSCs full stop and although there is no guarantee, I am very confident that all the parties listed above have done their due dilligence over the years to have this patent Estate secured.

Licensing - isn't that expensive?
If the Company exercises its rights to sub-license certain rights under the License Agreement, it must pay US$10,000 to WARF and also 30% of any fees received by Cynata from such sub-licensees in addition to certain annual and milestone fees, certain royalty and non-royalty payments as well as pay WARF certain reimbursement of patent fees and costs.
Whilst this might sound a bit "juicy", you may want to consider the alternative to Cynata's conservative approach of paying fees (US$10,000 per sub-license, 30% on milestone payments plus single digit royalties on net sales) on money it has actually received and is sitting in its bank account:Outright purchase of a / part/s of a platform or development of a new platform from scratch, requiring ongoing Capital Raises resulting in dilution of existing investors and / or loan/s (perhaps with - uncertain - future income to be used to service these loans and / or additional shares to be issued to repay the capital and therefore also resulting in further dilution of existing investors).
The above alternative/s could be compared with negative gearing, hoping that the income generated from this platform will eventually outweigh the ongoing expenses including interest and (lower) royalty payments (as there is generally at least one patented component required for the manufacturing process that needs to be in-licensed) and in this instance, will also allow for the loan/s to be repaid down the track with whatever is left.
My personal view on investing aligns with the conservative approach taken by the company. Having said that, Cynata is still considered to be a speculative, high-risk investment, especially in the absence of an (ongoing) income stream sufficient to cover ongoing expenses.


Please note:
The above content is still a "work-in-progress" of my interpretation of information available in the public domain and is not to be considered financial advice in any way. Feel free to agree, disagree and/or disregard, but do your own research. I am happy to discuss, especially if there is a contrary view based on more than just belief, but instead can be substantiated using also links to information available in the public domain. Otherwise I also reserve my right to disregard.
submitted by pfeifer1982HC to CynataTherapeutics [link] [comments]


2020.10.12 17:38 Several_Ad_4392 Who regulates NLP in the UK?

I have cause for concern regarding the toxic side of the self-development industry, its marketing towards children, families with sick children, and children with mental health problems. It’s application for ‘self-development’ that is being targeted towards children, as well as its use to treat medical conditions in children by those with no medical training or education; and alarmingly its encroachment into the school and classroom environments for both.
My hope is that this email will start a conversation with those who are best equipped to have it, so that the right action can be taken to ensure the welfare of all children.
There are a lot of people in this world selling snake oil, “cure all’s”, one in particular is N.L.P.
N.L.P. is part of the self-development industry which is estimated to be worth globally $15 billion with nearly 6% average yearly gains. To put it lightly, people are making serious money from self-development. The selling of books, seminars online programmes, podcasts, blogs, live speaking events, and coaching are some of the mediums used.
This is potentially problematic because, put simply, people are more profitable to the self-development industry if they are unhappy and discontent, than they would be if they are happy and fulfilled.
In order to successfully market any self-development product, a sense of self dissatisfaction needs to be created in the prospective market or customer. In order to pull them in this is achieved by projecting a feeling of inadequacy. In turn, each piece of self-development material consumed, be it a video, book, seminar, webinar, or 1 on 1 session with a life coach, will give the consumer a sense of wellbeing, a small high. This high is caused by a surge in dopamine levels that rise in the brain.
This is incredibly dangerous because it can create an addictive cycle of behaviour.
Self-development will make you feel good. There's no doubt about it. There's a feeling of satisfaction that anyone will have after finishing a self-development book, or after attending a seminar or coaching session, because these products are designed to give you a sense of motivation and accomplishment, especially in a group context where group social biases can make people vulnerable to the perceived inadequacies and insecurities upon which they are marketed to resolve. But that feeling of accomplishing something isn’t real because you haven’t actually accomplished anything other than consume a product that is designed to make you feel as though you have. Furthermore, that feeling of motivation, that bubble may burst due to external forces outside a person’s control, leading them to feel personally responsible for not having the success that was marketed to them, because they didn’t put in ‘enough hard work and commitment’ that you were told they needed to put in while their brain was flooded with dopamine. (Imagine this if you are suffering from depression, I’ll come to that later) Due to an increased sense of inadequacy this leaves people needing more and so the cycle of the consumption of more self-development material begins again.
The reason anything becomes addictive is not because of the thing itself. The reason someone becomes addicted to cocaine is not cocaine; it's what the cocaine does to the brain. It’s the rush of dopamine caused by cocaine that gets a user hooked. It’s the rush of dopamine that causes addiction. N.L.P. and other self-development products can cause pathological behaviour cycles by creating a dependency on the feeling of wellbeing triggered by dopamine. It does so by using social context and behaviour to turn people into a consumer of its products by playing inadequacy against success to create a false sense accomplishment and motivation that facilitates a dopamine rush, the high. N.L.P and other forms of self-development stimulate the same neurological and psychological mechanisms as cocaine.
In order to become an N.L.P. life coach or self-development guru I would suggest that you would have fallen foul to this kind of predatory marketing and in turn, in some way become addicted to its products and ideas.
There are many N.L.P. organisations. I will focus solely on the ones I have seen that are aimed towards children that I believe to be toxic.
Many N.L.P. organisations and self-development gurus market the idea to potential prospective N.L.P. practitioners of being your own boss (are you sick of the 9 to 5?), financial freedom (do you want less stress?), success (do you need people to think highly of you?), all whilst helping children. You can do this after attending a course lasting only 4 days. Some even with one of those days spent on teaching someone how to set up a children’s therapy practice, and how to market their particular brand of N.L.P. as a franchise. Shockingly but not unsurprisingly there are optional add-ons, so after attending and successfully passing your short course, you can pass on your new N.L.P. skills to parents, and teachers.
Some of these N.L.P. and self-development practitioners take the opportunity to present themselves as a guru with promotional video testimonials from their ‘licenced practitioners’ praising them for their support and helping them achieve success, and finish as all new wave internet gurus do with “make the commitment”, “hard work”, “earn money” and “success”, with the offering of monthly private webinars and closed forums of N.L.P. and self-development content and not failing to subtly mention the financial commitment to your new guru to ensure your skills are up to date so you can acquire your next annual franchise licence for your successful N.L.P. business in what, on the face of it, appears in some instances to be a pyramid scheme.
Some of these N.L.P. and self-development organisations seem to blur the distinction between a medical licence and a franchise licence and sell the idea of helping children with medical conditions to potential practitioners who may then go on to think that because they are a ‘licenced N.L.P. practitioner’ and may already be a registered child minder, and have a clean police check; they can treat the symptoms of a number of medical conditions that could have their roots in all kinds of serious conditions that these practitioners would lack the competencies to diagnose.
One video testimonial I have seen, the new practitioner states they felt dissatisfied with the corporate world, so signed up to become a child therapist, and so applied to attend and after a 4 day course was a child therapist.
In short you can quit your job at McDonald’s on Monday and by Friday be under the illusion that you are a ‘fully registered and licenced’ child therapist.
I struggle to reconcile the notion that it is possible to become a professional child therapist, regardless of whether or not you then operate in schools, but especially if you do, after completing a course lasting less than a week. I further struggle to believe that you can tell people that you are a licenced child therapist after completing one of these courses. I struggle more to believe that people who don’t have a degree in psychology or any medical qualification who are not doctors or professors are allowed to teach people to become a child therapist and give them the illusion that can work with children and in schools.
It is my belief that this appears to actually be happening.
Schools, while having checks in place may fall short, because their child mentors and class support workers have a clean police check and are registered child minders and when they say they are a ‘licenced practitioner’, do schools realise this isn’t from a recognised medical training scheme and in actual fact issued by someone selling ’self-development’ franchises on the internet in an unregulated industry that the scientific community has dismissed due to its numerous factual errors and its lack of empirical evidence for effectiveness and recognises as pseudoscience.
When it comes to diagnosing medical conditions, a medically trained professional, a Doctor, will, after many years of study, approach any patient with a degree of scepticism, and after rigorous investigation and the process of elimination rule out what things are definitely not, in order to find out what things may be, before narrowing down a diagnosis and then deciding on the correct course of treatment for a given condition. N.L.P. practitioners after a 3 or 4 day course won’t be able to do this, and would, with an unscientific mind, approach a patient with any given condition with flow chart diagnostics. They will look for certain symptoms that they could potentially treat with N.L.P. Once confirmation bias has falsely validated a condition, they would then apply their N.L.P. techniques to treat what they believe can be treated with N.L.P.
Should they have accurately diagnosed a condition, blind luck will be interpreted as success.
Anxiety, O.C.D., A.D.H.D., Anger, Depression, , could all have social triggers, but are also symptomatic of other very serious conditions that N.L.P. practitioners would not be able to recognise with flow chart diagnostics let alone effectively diagnose or realise they should even be aware of after attending a 4 day seminar. As such, this could cause significant problems further down the line for a child with autoimmune disease, or perhaps a genetic condition like hemochromatosis, McLeod Neuroacanthocytosis Syndrome, Cushing's Syndrome (the list can go on) or in the worst case some types of Cancer.
The symptoms of conditions these practitioners are treating could also be early onset schizophrenia. Schizophrenia causes all sorts of social and psychological symptoms because it is fundamentally a language disorder that in part robs the patient of the capacity to distinguish between their internal thoughts and the real world through something called ‘concrete language’. If you apply some one size fits all thinking techniques to a person (a child in this instance) suffering from this form of psychosis, the damage that could be done is catastrophic and potentially puts people, (children), in serious danger.
As a more frightening example, Depression (in its truest most destructive sense) is a genetic neurochemical disorder, that is as biological as diabetes, which through the impact of life experience influences, or perhaps just any way robs people at a biological level of the ability to experience joy. (Consider here what I mentioned above - that sense of personal responsibility for failure) Combine all this with people’s inability to distinguish the difference between being depressed and having depression due to semantic similarities and the social stigmatisms that further impact the psyche of someone who is already withdrawn and you have a cocktail for disaster. You can’t just sit them down and go through some thinking or social behavioural techniques and expect it to improve. This is because Depression, a neurochemical disorder, is in most cases a serotonin deficiency. This is analogous to sitting a diabetic down and telling them to snap out of it and hoping that in so doing their pancreas starts producing insulin.
Depression is treated with professional therapy in conjunction with prescribed S.S.R.I. medication to trigger the production of serotonin in the brain. N.L.P. and other self-development products release dopamine. Neurochemically speaking this is comparable to treating depression with a cocaine habit. Children will report that they will feel better. Neither these practitioners, children, nor parents would be aware that they are actually not better and have in actual fact substituted a lack of self-worth, with a short term high, just like a ‘fix’. The damage that could be done here could result in suicide. This is because a patient with depression is at their most vulnerable from suicide when they are going through what appears to be a recovery; when everyone around them thinks they are doing well; after a period of psychomotor retardation, as they now have energy to take action on their self-destructiveness and self-harming thoughts.
I would suggest, the positive results that these organisations are reporting for treating Depression (as well as a number of other conditions) are in actual fact the result of a fallacy of composition biased by false validation because N.L.P. makes people ‘feel good’. In some cases children, sick children, who are potentially becoming hooked on the dopamine rush from consuming self-development products from an unregulated industry that has found its way into the classroom. I would further suggest that these statistics are in actual fact an alarm bell that should be seen as the number of children, potentially sick children, who are becoming self-development product addicts.
While the above may be extreme worst case scenarios, of which there could be more. Where more unnoticed damage could be done is in the realm of personality disorders and pathological behaviour.
Brain chemistry plays a huge role in personality disorders. ‘Messenger chemicals’ such as the previously mentioned serotonin are used in the brain to transmit signals between brain cells. Altered levels of serotonin have been linked to depression, aggression and difficulty controlling destructive urges. All of which some N.L.P. organisations wrongly target with their N.L.P. therapy which triggers dopamine.
In addition to this, if a person is overly sensitive to negative emotions and is neurotic, N.L.P. practitioners conditioning a child to avoid circumstances that may trigger negative feelings or reconditioning their thinking about these circumstances with repetitive self-affirmations reinforced with dopamine, could lead the child to develop a pathological narcissistic personality disorder simply because practitioner, parent, teacher or child wouldn’t be able to determine the difference between an angry child feeling better due to dopamine, and creating pathological behaviour models that will become malignant over time.
Are parents made fully aware that their child’s mentor, classroom assistant or even therapist; are offering or passively using potentially addictive pseudoscience from an unregulated industry for personal development? Furthermore do they realise in some cases offering this as a treatment for what they don’t realise is more often than not symptoms of autoimmune diseases or genetic disorder that require proper medical treatment? While these practitioners may have passed a police background check, and who are ‘fully licenced’, do the parents realise that these practitioners in actual fact have no medical training or education? Do parents realise they in fact only have a franchise licence from an unregulated industry issued after a 4 day course by a person; who in one instance that I have seen, who also has no formal medical training or education and holds only a certification in nursery nursing?
N.L.P. used by a psychiatrist with an advanced degree and understanding of psychology I am sure presents no problem what so ever. In fact there are numerous success stories about it positively changing people’s lives all of which are highly commendable but in these instances N.L.P. was applied by a trained any qualified psychotherapist.
N.L.P. in the wrong hands, like someone with no medical background having completed only a 3 or 4 day course is in my opinion reckless and incredibly dangerous. It is then being used to treat children’s medical conditions by people who are not qualified to know what they are doing. As well as being used in the application of self-development by exposing children to a potentially addictive cycle of consumption, that in the short term may make a child feel good, but in the long term may have catastrophic consequences.
The self-development industry could be seen as a community of individuals and entrepreneurs looking to better themselves. These life coaches could be seen as providing value by trying to make people’s lives better. I am sure some of them are. So where’s the harm? This is naive thinking when you're dealing with an unregulated industry that is worth billions that relies upon creating a sense of vulnerability and inadequacy to snare its practitioners that can then potentially be projected onto others to make a profit on potentially addictive products especially when they are marketed to children with medical conditions. In seems to me to be a pyramid scheme glued together by projecting social inadequacy onto the next person, so they can return a sense of affirmation.
It is my belief that there are people in The U.K. and quite likely elsewhere probably globally who have no medical qualifications, using potentially addictive N.L.P. techniques on children in schools. They have no education in psychology, they are not psychiatrists, and some have no medical qualifications. Some have only done a course only a few days long. Some of these people are treating psychological problems in children in schools.
I want to be clear, I am making no accusation of abuse against any individual, or organisation. There is no conspiracy, there is no malice. It is only my opinion that this is something that could potentially be harmful to children being committed naively by those who probably have the best of intentions, who are ignorant in their actions. This in my opinion has been allowed to take place due to an institutional failure that has let the potentially toxic side of an unregulated industry slip through the net and find its way into the classroom.
Please approach this with due diligence and care, children are involved, practitioners may have children, who could be exposed to backlash from sensationalist reactions.
The self-development industry is unregulated, and that needs to change. Step one, get it out of the classroom.
Should N.L.P. be regulated?
View Poll
submitted by Several_Ad_4392 to NLP [link] [comments]


2020.10.10 18:00 subredditsummarybot This Week's /r/VBA Recap for the week of October 03 - October 09

Saturday, October 03 - Friday, October 09

Top 5 Posts

score (1+) comments title & link
18 11 comments [Discussion] What books/written ressources to sharpen and improve my Excel VBA code?
6 6 comments [Unsolved] Double Double quotation marks messing up forloop
6 27 comments [Discussion] [EXCEL] A script that checks the same cells in multiple spreadsheets against a master spreadsheet and then removes duplicates from the master
6 1 comments [Unsolved] VBA Batch replace PPT
6 3 comments [Discussion] What have you been working on? (Week of October 09, 2020)
 

Top 5 Comments

score (1+) comment
9 Getinmazone said camera.exe isn't a valid program. Try this microsoft.windows.camera: Edit: To ever test if a program is going to be found, use the windows - r; if you are able to open the file from there, then it s...
8 BrupieD said I found some VB.NET books to be really helpful for bringing my skills up. The vast majority of VBA books are introductory/beginner-level books. Intermediate to advanced level books are relatively rar...
8 IthinkImCute said Its been a while since I've worked in VBA, but I think that instead of Worksheets(""" & Status & """) just Worksheets(Status) would do the trick so long as Status is a variable c...
6 ViperSRT3g said You need to modify the second sub so that it accepts an argument like so: Sub Second(Byval VarInt as integer)
5 ItsJustAnotherDay- said One particular topic that increased my power is to dive deeper into ADO. The ability run SQL queries on excel files, csvs, connect to other databases and execute stored procedures there using paramete...
 
submitted by subredditsummarybot to vba [link] [comments]


2020.10.09 10:57 ouija1733 How to extract Latitude and Longitude from a response XML maintaining the dot.

As the title says, im having a lot of trouble getting latitude and longitude data from a XML im getting as resoult from a call to a web service. Im expecting to get something like 44.2342 but i get 442342 and thats not what i want. i'll write down here the things that im using:
This is the XML that i get from the bing map service
Copyright © 2020 Microsoft and its suppliers. All rights reserved. This API cannot be accessed and the content and any results may not be used, reproduced or transmitted in any manner without express written permission from Microsoft Corporation. http://dev.virtualearth.net/Branding/logo\_powered\_by.png 200 OK ValidCredentials b20adffab84f4ada81b962a6b0b5ebdfDU00000D7A0.0.0.1Ref A: 88EBDB47338B46BEAD306AB80512CF5C Ref B: DB3EDGE0909 Ref C: 2020-10-09T08:48:58Z 1 Via XX Settembre 11, 17100 - Savona, Italy 44.3060943 8.4779457 44.302231582429322 8.4707491956539478 44.309957017570675 8.4851422043460509 Address
Via XX Settembre 11 Liguria SV Italy Via XX Settembre 11, 17100 - Savona, Italy Savona 17100
High Good 44.3060943 8.4779457 Rooftop Display 44.3060702219873 8.47782736192207 Rooftop Route

(For better view please use an auto identer or just copy-paste in a .txt)

And this is the Formula im using to extract latitude from the XML:
[email protected](C21;"//Latitude[1]")
And it put in the cell 443060943 instead of 44.3060943
Thanks in advance to whoever even try to help me ^^
submitted by ouija1733 to excel [link] [comments]


2020.10.04 10:11 Hero0fTheFallen $SNDL DD, upcoming ER, Covid-19 information & upcoming pipeline PR, Photos and communications included

SUNDL DD, Current value $0.24 currently heavily undervalued.
Sundial Growers has 5 different brands of marijuana each brand for different types of consumers.
Value - Grasslands Core - Palmetto, Sundial Premium Core - BC weed Co Premium - Topleaf
Q2 2020 commercial highlights:
• Branded net cannabis sales increased to 82% of total cannabis sales from 54% in previous quarter.
• Improved 'On time in full supply chain' (OTIF): January 25.8%, June 96.4% allowing quicker and more streamline deliveries.
• Net Cannabis Revenue: $20.2MM 44% Vs Q1 2020.
• Branded sales shift to 69% vs 54% Q1 2020.
• Reduced SMG&A by 33% vs Q1 2020.
• Debt restructuring & capital raise.
• Disposition of bridge farm assets.
• Huge cost saving changes, from cultivation of $32MM² to corporate head count reduction of 50%.
Covid-19:
Pathway RX a research company dedicated to developing custom cannabis therapies to treat specific diseases, announced that they intend to further advance their research to evaluate the potential for medical cannabis to treat covid-19 and it's possible complications.
This research will include clinical trials and research papers for peer-review, to validate the safety and efficacy of medical cannabis to treat covid-19.
Results from a study by Pathway Rx were recently shared publicly and the research paper was submitted to a scientific journal for peer-review. The study's data suggests that a limited sample of high CBD Cannabis sativa extracts modulate ACE2 gene expression and ACE2 protein levels in gateway tissues of the COVID-19 causing virus and also have the potential to inhibit its entry into cells, curtail disease spread and reduce mortality.
The study was conducted using artificial human 3D models of oral, airway, and intestinal tissues. A second research study that examines the use of cannabis extracts for taming the cytokine storm will be published soon.
Among the 1,000 Cannabis sativa varieties that have been screened by Pathway Rx, only a small number have expressed medicinal properties.
The most promising of these varieties are licensed to ((Pathway Rx's commercial partner Sundial Growers Inc. (Nasdaq: SNDL) and are currently in production at its facility in Olds, Alberta)).
Pathway Rx aims to seek funding from many sources to support its research goals including the recently announced $1.1 billion from the Canadian Government to support scientific initiatives to address COVID-19.
"The Government of Canada's latest investment to support the health of Canadians creates a significant opportunity for Pathway Rx to advance our research and accelerate the development of custom therapies and products to help combat COVID-19," said Dr. Kovalchuk.
Asia Green BioTech:
Asia Green Biotechnology Corp has Expanded their Technology License Agreement with Pathway Rx Inc. by Entering Corresponding Agreement with PNW Biosciences Inc.
Upcoming ER is estimated to be released early November, with better growth overall.
Q1 was down significantly due to delivery standards, however, Q2 saw I huge improvement overall leading to delivery standards of 95%+ meaning Q3 if trends continued we should see a very large increase of revenue overall.
The current projection for many analysts is $0.63 by end of year, however, insiders believe they'll easily obtain $1 with upcoming PR as shown in email correspondence with "Sophie".
Even if you do not hold till ER as they do have a deadline of December to meet $1, the possibility of gaining 100%+ is quite high!
(Just like to point out I'm in @0.24 & thus not pumping for my own benfit, I've been swinging this on & off all week as its ranged from 0.20 - 0.33 peak).
Hope this is interesting, as it's my first DD, photo link below showing data and emails with Sundial growers investors team, any feedback would be awesome !
😁 Hope you all have a nice weekend 😁
Photo with DD relevance
Edit:-
Thank you for the acknowledgment, didn't think DD would take as long as it did, especially the emailing part of it, hopefully this will get a few of you some gains this week ! 🧡
submitted by Hero0fTheFallen to pennystocks [link] [comments]


2020.10.01 22:54 500scnds [Table] IAmA dark web expert, investigative journalist and true crime author. I’ve met dark web kingpins in far flung prisons and delved the murky depths of child predator forums. I’ve written six books and over a dozen Casefile podcast episodes. AMA (part 2/2)

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Questions Answers
Around here nobody talks about the argument that increased regulation of the internet would help stop child predators. Is that true, and if so where do you fall on the Net Neutrality vs law enforcement spectrum? No I don't think that's true at all. Child predators have been around much longer than the internet, and I would argue child abuse was more prevalent 50+ years ago when children were seen and not heard and it wasn't talked about. The dark web hasn't created more predators, it has just given them a new place to gather and hang out.
The one thing I found really interesting when I was lurking the forums of the child predators was their frustration about how children are now taught from a very young age that certain touching and acts are wrong and that they shouldn't keep certain secrets. It came up over and over again that they could not abuse certain children because they knew those children had someone they would tell. It was pretty clear that education was a child's best defence against getting abused.
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That's so interesting, thanks for the AMA! Can you remember any other thing that a child could do in order to protect himself from being abused? What other characteristics do the abusers hate in potential victims? That seems to be the main one. Kids who speak up and who have close relationships with one or more people they are likely to confide in
What do folks talk about in the child predator forums? Do they like give each other advice on how to improve their craft? Yes, quite literally. The give each other tips on how not to get caught, how to edit out incriminating details in videos, how to drug children, techniques for convincing kids not to tell etc
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Given your insight into how predators operate, do you have any advice for parents on protecting their kids? I'll cut'n'paste a response i gave to someone else about this, because it was something that really stuck out to me:
The one thing I found really interesting when I was lurking the forums of the child predators was their frustration about how children are now taught from a very young age that certain touching and acts are wrong and that they shouldn't keep certain secrets. It came up over and over again that they could not abuse certain children because they knew those children had someone they would tell. It was pretty clear that education was a child's best defence against getting abused. Kids who speak up and who have close relationships with one or more people they are likely to confide in
Has the exponential increase in Bitcoin value affected darknet dealers in any profound way? I can imagine that some drug dealers were sitting on quite a large sum of Bitcoin when the value shot up. Crypto purists hate to admit it, but bitcoin would not be where it is today without Silk Road. It was sitting at less than a dollar when Silk Road began and the markets showed a robust use case for cryptocurrency and as the markets grew, so did the demand for bitcoin. It also provided real-life use data for those who were not interested in drugs but who weren't sure if it had practical application. When SR went down, Bitcoin was at about $650 and it continued to grow as adoption became more mainstream. There are many many stories of drug dealers (and at least one faux-hitman!) who gained most of their wealth not by selling the drugs, but by the growth in value of their bitcoin holdings
Since you have a lot of experience with them online. Do you think pedophiles(not child abusers) should be treated as criminals, or as people suffering from a mental illness? Contact offenders should be treated as criminals, because they are criminals. They have abused or hurt someone. Same with those who support the creation and dissemination of child abuse materials.
Pedophiles who do not act on their urges should be given as much help as humanly possible.
Are there any mysterious or suspicious pages or communities that you haven’t been able to access? Anything that seems especially weird? there are a lot of Russian communities that I can't access, mostly because I don't speak Russian. Some of the more technical hacking communities have entry barriers that I'm not technical enough to score an invite to
How much these bad people really exist out there? Hundreds? Thousands? More? It depends what you mean by bad. If you mean people who use the dark web to buy drugs (who I do not consider bad) then there are many many thousands. There are also thousands of people who deal in stolen information to make money.
Unfortunately there are also thousands of child predators and the dark web has provided a "safe space" for them to come together to share materials and "tips". I hope this is where most of the resources of law enforcement are concentrated
Ehy mine is a rare question: what do you know about art on dark web? I'm talking about the black market made of stolen important pieces from museums, art used as value to money laundry and other criminal affairs I'm an artist and what I know is people don't think too much about the dark side of art and probably they need to open their eyes about I really haven't come across much in the way of that. Some of the markets have an "art" section, but that is mostly blotter art
How accurate are the legends? Any legends in particular? For a lowdown copied from a post I made in another forum:
1Red Rooms  The one that is most persistent is the myth of the "Red Room" - live streaming of torture/rape that ends in the murder of the victim and which people can pay to watch, or even bid to type in commands for the torturer to carry out (highest bid wins!). The most famous was the “ISIS Red Room” pictured above, where people could provide instructions to torture captured terrorists - you can read what happened here.
People have this idea of Hostel with webcams exist all over the dark web, but you just need an invite to get into them. It's ridiculous. They don't exist. They certainly wouldn't exist on Tor. But people are desperate to believe and they always come back with "You can't prove they don't exist, people are crazy, therefore they must exist." Picture my eyes rolling here.
2.Hitman sites
I don't think many people are taken in by the hitmen sites anymore, though the press loves playing up the fact that there are sites offering up hitman services. But every single one of them has turned out to be a scam, especially Besa Mafia, the one that did the most marketing. Again, you can read about it at the same link as above.
3.Exotic animals  People are always asking where they can find markets for exotic animals. Obviously the illegal trade in exotic animals exists, and some communications and transactions may well take place over Tor, but there are no markets like the drug markets where you can go and look at a picture and then put a tiger or ocelot or something into your basket and buy it with bitcoin.
SO WHAT DOES HAPPEN ON THE DARK WEB?
1.People buy and sell drugs.
The drug markets are more busy than ever. You have probably heard of Silk Road, the most famous online drug market that got busted a few years ago and the owner sent to prison for two consecutive life terms? A lot of people thought that was the end of drugs being sold on the dark web. In fact, dark web sales of drugs have tripled since the shutdown of Silk Road.
The reason people buy drugs this way is that for many they offer a safer alternative for people who are going to do drugs anyway. There is no possibility of any violence. The vast majority of the time a buyer knows exactly what they are getting, because of the feedback and rating system. That's not the case in a nightclub, or even friends-of-friends, where you just blindly accept that the pill, powder or tab is what the seller says it is.
2.People buy and sell other illegal things
Mostly they buy and sell stolen credit cards and financial information, fake IDs (though lots of these are scams), personal information, “dumps” of hacked data and fraud-related items. For a long time, a seller was making a fortune selling fake discount coupons that really worked.
3.People access and create childporn  Unlike the other markets, the CP market is generally not for money, but rather they are groups who swap vile images and videos for free. The worst of the worst is called “hurtcore’. Thankfully, most of the people behind the worst sites have been arrested and put in jail.
4.People talk about stuff
There are plenty of sites, forums and chatrooms where people talk about all sorts of things - conspiracies, aliens, weird stuff. They take advantage of the anonymity.
5.People anonymously release information
Whistleblowers use the dark web to release information and make sure their identities won't be compromised. You will find Wikileaks, for example, on the dark web.
6.People surf the web anonymously
The number 1 thing people use the dark web for is just to surf the web completely anonymously. Not everybody wants to be tracked by advertisers.
I have a question: what are the odds of the casual Darkweb drug buyer - not buying mega loads all the time - the occasional purchase - what are the risks of being busted? Kinda figuring pretty low. But you’re the expert. What do you think? Obviously there is always a risk, but the risk is very low. It is rare for personal amounts to be seized. Even if a package is seized, there's usually no resources to follow it up. Many people report simply receiving a letter from Customs saying they have seized what they believe is contraband and the person has a choice of going to claim it or it will be destroyed. Even if LE does knock on the door there is plausible deniability: "I don't know who sent that stuff to me".
So yeah, rare, but it does happen. You might be the unlucky one
How do you find things on the dark web without search engines? There are a lot of entry sites, set up with links to the most popular places. You can generally get a link to one of them by browsing places like reddit. From there it is a matter of checking out different places, people will put links in forums etc.
I also use a Pastebin where people paste sites they have made/found, and a Fresh Onion site, which crawls all the newly-populated .onion addresses
Hi. there!! Thank you for answering questions. Mine is very simple. How do sellers get the drugs to people? Regular mail? That's always puzzled me bc I'd assume USPS, UPS, fedEx or any other mail carrier would catch at least some goods. If people are ordering drugs, particularly in powder form, for personal use, they can be flattened, sealed in MBB (moisture barrier baggies) and sent in a regular business envelope, indistinguishable from billions of other envelopes going through the postal system every day. The chances of a particular package being intercepted is very low.
Some people take the extra precaution of having the person taking delivery of the drugs different to the person/household that is ordering them.
How did you move from being a corporate lawyer to researching and writing about dark web? I was in London, working for one of the most conservative law firms in the world when the Global Financial Crisis hit. I liked the job but it struck me when people were losing their livelihoods that I was working for the bad guys. I'd always wanted to be a writer so when I came back to Australia I quit law and enrolled in a writing course planning to be a novelist, but I discovered I was better at journalism. I first wrote for newspapers here about Silk Road and it grew from there
I've always wanted to check out the dark web, what is a normal day for you look like on there? Can you give me any tips on how to safely surf the dark web? A normal day looks like me sitting at my desk writing things on my computer. When I'm researching a book or a case I venture away from my computer to trials and to interview people (at least I did pre-COVID)
There is nothing inherently unsafe in surfing the dark web. All the usual precautions you take surfing the clearweb apply. Don't visit any child exploitation sites - it will be pretty obvious that's what they are by the names/descriptions before you log in.
It is only when you want to do more than surfing - e.g. buying drugs etc - that you need to do a LOT of homework or you will absolutely get scammed
Is there anything good about the dark web? It depends what you are into. A lot of academic research has concluded that the darknet markets provide a safer way for people to buy and use drugs, due to the ratings of vendors, services that independently test and report back on batches of drugs, doctor on staff ready to answer questions, no violence in transactions etc.
News sites provide a dark web option so that whistleblowers can safety provide information and upload documents that get stripped of any identifying metadata before being available.
It bypasses firewalls and allows for secure communications under hostile regimes
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How does this make you feel about the idea of the decriminalization of drugs? I've always been for full legalization of drugs, and studying the darknet markets just proved I was right.
I was invited to an experts roundtable in Portugal about drugs and cybercrime a few years ago and the Portugal model of decriminalisation has been a great success
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Hey, you are still answering. Been reading this thread for 1-2 hours now. Thank you so much for all the good work and info! Always been intrigued by this topic, downloaded tor once to explore a bit but couldn’t and deleted it right away, to be on the safer side. Great insights. Thanks! I've been writing it for about 14 hours. Going a bit loopy
How was working on Casefile? What's the production process like? Which episodes did u do?? I have listened to... all of them.... I absolutely LOVE working for Casefile. I am a freelancer, so I source and write my own cases and then sell the scripts to Casefile. I've done at least a dozen, but some of my most popular are Amy Allwine, Mark & John, Ella Tundra, Leigh Leigh, Rebecca Schaeffer...
As for the production process, once I have sold the script to them, a staff member edits them and then they are passed on to Casey to narrate. After that, they go to Mike for sound editing, music etc. They are the best team ever
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Oh, Leigh Leigh was so well written!! How do you choose which stories to write? Do you just pick true crime you're interested in? Thank you! I have a huge list of potential episodes. Any time I come across an interesting crime on reddit, or in the news or wherever I make a note of it. Then I just pick one when it comes time to write a new script.
Sometimes I've been personally involved (e.g. Amy Allwine), gone to trials etc. Those are always the best ones
Hi Eiley, your twitter just reminded me of this AMA :) What are your thoughts on bitcoin? And would you prefer to be paid in crypto or fiat? OOOOH, I know that name! Love & Light to you!
I like Bitcoin and I wish I had a whole lot of it and like many many people, I wish I had kept the first crypto I bought at something like $4 a coin :D I do not have a whole lot of it but I do have a little bit. I like the philosophy behind it and in theory it should change the world. However the reality is that the vast majority of it is concentrated in a very few hands which allows for market manipulation and stops it being useful as a post-fiat currency.
As long as I'm getting paid, I'm pretty happy!
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I too remember your name Pluto! Such a decent human ❤ he is!! True OG right there <3
Is the dark web subject to more racism than its counterpart, the world wide web? There are some white power sites and that sort of thing and the chans are even more uncensored than the clearweb ones (4chan, 8chan) but to be honest they are the same cesspools in different spots. Drug forums don't seem to be very racist. I've seen worse on Twitter
Have you seen any consequential political or social organizing being carried out on the dark web? Not directly, but the dark web helped facilitate the Arab Spring uprising in 2010 by allowing activists to remain anonymous and to access blocked websites and social media. Wikileaks, obviously. Some white supremacy organizations seem to use it to coordinate attacks, but they are not places I'm keen to hang out in.
What’s the most expensive thing for sale you’ve seen on the dark web? What was surprisingly inexpensive? I can't remember specific listings, but there were sometimes sales of things like coke by the kilo, so that sort of thing I guess.
LSD could easily be found for $1/tab and one huge dealer gave it away for free if it was for personal use
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1. I’m going to ask a couple in hopes that one will catch your interest! I know you’re anonymous on the dark web, but even so, have you ever felt worried about your safety? I actually made the decision to be upfront and honest about who I am on the dark web, so I use the name OzFreelancer (which is easily traceable to my real name) on all the dark web sites where i went looking for interviews. The people there had the option of talking to me or not, so they had no reason to want to harm me.
2. I’ve found your comments about your relationship with Yura fascinating. Did y’all develop a friendship? Did you build any other relationships that stand out in your mind? Since you were straightforward about being on the dark web for stories, did people seem reluctant to communicate, or were they excited for the opportunity to divulge a secret? We do have a friendship of sorts, it is really quite weird. I do hope to met him one day. I met all of the senior staff of Silk Road other than the Dread Pirate Roberts himself and keep in touch with some. Some people wanted nothing to do with me of course, but many more were happy to talk to me. i think sometimes it was a relief to them to be able to talk to one person who they knew was who they said they were.
3. On violent forums, did users ever express remorse, guilt, shame, or anything indicative of some recognition that what they were viewing/seeking was awful? Do you see doxxing teams on the dark web working together to uncover info, or is the info already there through previous hacks/breaches, and someone just accesses and releases it? Sorry if any of those don’t make sense! I’m not familiar with the dark web lingo but am so intrigued by your work. Not really. I think if they were contributing to the forums, they were comfortable with who they were and what they were doing. Many of the "regular" pedophiles expressed revulsion about Lux and hurtcore sites though
these have probably been asked before but has there ever been a time where you where genuinely been scared for your life and whats the most messed up thing you've witnessed did you have any help? Yeah both things have been answered in this thread, so I'll cut'n'paste
The only time I've felt even slightly in danger despite all this nosing around in there was when I helped uncover a hitman scam. The owner of Besa Mafia, the most profitable murder-for-hire site in history, came after me when I started writing about him. He made loads of threats ("you don't know who I am, but I know who you are and where you live") but that wasnt scary, as I had access to the backdoor of his site thanks to a friendly hacker and knew he didn't really want to hurt anybody.
It took a bit of a darker turn when he told the people who had signed up to work as hitmen on his site - and who he made video themselves burning cars with signs on them to advertise how legit his site was, then never sent them the promised money for doing so - that I was the owner of the site who had ripped them off. That could have become ugly, but luckily even the thugs weren't dumb enough to believe him.
The only other time I've been a bit nervous was when Homeland Security wanted to have a "friendly" meeting with me on one of my trips to the US to attend a trial. They were friendly, but scary too.
The most frightening experience I've ever had is coming face to face with Lux, the owner of Pedoempire and Hurt2theCore, the most evil and reviled person on the entire dark web. He was responsible for procuring and hosting Daisy's Destruction, the most repulsive video ever made, created by Peter Scully, whose crimes were so bad, the Philippines are considering reinstating the death penalty especially for him.
It wasn't frightening because Lux was frightening - he was anything but. It was frightening because he looked so inoffensive and normal.
It was frightening because he was living proof that monsters walk among us and we never know.
[deleted] It is absolute crap for browsing the clearweb, and a lot of sites detect that it is odd traffic and you have to solve their CAPTCHAs before doing the most basic things
I’m sure you’ve seen some really bad stuff, do you regularly talk to a therapist to help? I've never seen a therapist (they don't really seem to be a thing in Australia they way they are in the US), but I have been known to unload on my partner and my dog
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Yo, speaking as an Aussie, they absolutely are a thing, you can get them covered thru medicare, and I recommend it if you possibly can! Bro, therapy is awesome. I'm not against therapy as a thing, but I've honestly never been so traumatised that I feel I need it. Also I had a bad experience with a psychologist after I watched my partner die in an accident - they suggested I find God, and I noped out of there
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Therapist is an American term- we call them psychs. And the one who told you to find God was terrible and out of line. Yeah she didn't last long before I was over it. Also a doctor decided I needed Xanax, which was also a bad move, because what I really needed was to grieve and Xanax doesn't let you do that properly
Do you find any good things on the dark web? Happy stuff that gives people hope? Or just the trash? I like the psychonaut communities. They just want peace, love and mungbeans for everybody
Have you heard of "The Primarch System" rumor of the dark web? Sounds downright silly to me. But I'm curious if anyone who spends time on the deep web actually takes it seriously, or if as an idea it is connected to anything serious at all. Nah, up there with the Shadow Web and Mariana's Web. There's always people who want to find out where the "deeper" "more secret" "really dark" stuff is. To them I say what, hurtcore isn't dark enough for you?
Doesn't delving the murky depths of child predator forums categorize you with the child predators in the eyes of an investigating law enforcement agency? Do you have some sort of amnesty due to your journalism, or is that something you worry about having to explain away? Has your presence there ever caused some sort of a scare? No, I never went into any of the sites that had actual photos or videos (you can't un-see that shit), but did spend a lot of time in pedophile discussion forums. I also went to a hurtcore hearing and saw screenshots in the police files, as well as listening for two days to videos being described frame-by-frame and private communications between the site owner and the sadists.
Besides drugs and sex crimes, what else is going on in the dark web? Are there other interesting nooks and crannies? I often post screenshots of bizarre sites I find on my Twitter. However, the main uses for the dark web are drugs, digital/fraud goods and child exploitation
I have one, it might be rather boring though, but here goes. On these "child predator forums" are they actually forums devoted to stalking children and do they share social media profiles of children among themselves? That would be kik ids, snapchat and facebook ids, instagram, stuff like that, info that would allow online access and that may have been chosen for suitability? Creepy question I know, but anyway I would be interested to hear your answer. I came here from TrueCrime, you referred to these things in your post on that sub. I suspect I already know the answer yet would like to hear your take on it. Yes, they provide information and tips on how to approach children, how to ensure they won't tell, how to sedate them in some instances, where to find child exploitation material, how to remove metadata and any identifying characteristics in photos and videos before sharing and so on.
They don't tend to share socia media, as that is the sort of thing that can be traced easily. They do talk about how to approach kids on social media and on the worst forums how to blackmail children into stripping/meeting etc
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So you're saying they have a more general approach rather than identifying individual children on the internet? Again a creepy question because what I suggest is that a child's social media could be used and circulated on the dark web as potential information to gain access by anonymity, even if it was just online access only. I actually wonder as I have recently read of the anonymity of apps like ''kik messenger'' and how the police are often unable to get any information from the communications as they remain encrypted and off the server and require little if any valid ID to make an account. No doubt photos from social media are uploaded as part of the materials they have. I haven't seen anything where they get together and try to track down a specific child, but I'm sure some predators do this. Most are more likely to abuse children in their orbit - family, kids of friends, or they work where they have access to children
I heard there are forums to download books but it was really dangerous, Is it true? I'm just a poor guy who wants to finish the young Jack sparrow series Whenever you download anything from a pirate site you run the risk of infection
What do you think of QAnon? Wackjob conspiracy
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Who should the conspiracy theorists actually be worried about if they actually care about thwarting pedophilia? The vast, vast majority of child abuse takes place within the child's personal orbit - relatives, family friends, parents of their own friends, people involved in their activities (coaches, leaders, etc)
So, those people
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Also how to we get people to stop believing in QAnon? Outside my area of expertise, sorry
do you personally believe there was/is any truth to the "defense" (story) that DPR was a title handed down to different admins for the original silk road, or was it just a convenient defense? do you have any theories as to who satoshi nakamoto is? besides the original SR, are there any other darkweb markets that you think have a good enough story to turn into a book? eg sheep market? i've seen you talk a little about the child predator forums, and (as with h2tc) noted are mainly populated by males. i'm curious if you've ever encountered females on such forums/websites (eg. btfk) No. There was a time that I believed the person posting on the forums as DPR changed, but the ownership and administration of the market I believe never changed hands. Variety Jones is claiming a part ownership (which may or may not be true) but I believe that is so he can run a Fourth Amendment argument
So many theories have some credibility to them, but no one theory ticks all the boxes. Highly recommend the 3-part youtube deep dive by Barely Sociable
I'm not sure any one market has the story that Silk Road had, but I would like to write a definitive history that encompasses the most compelling features of all the markets. Backopy of BMR apparently got away clean. The admins of Atlantis got wind of a security issue and closed shop, trying to warn DPR. AlphaBay ended in Alexander Cazes death in a Bangkok prison cell. Then everyone flocked to Hansa, which by that time was being run by law enforcement. Evolution ended in the most brazen exit scam, followed by a bizarre cloak'n'dagger situation played out right here on reddit. The WSM/DDW follow-the-money case. And these are just some that come right off the top of my head. I just need a publisher to provide me an advance I can live off while I write it!
There were a very few people on the forums who identified as female (obvs anyone can be anyone on a dark web forum) and there have been one or two arrests of women in relation to dark web child pornography. Peter Scully's female assistant who carried out some of the torture was originally one of his victims, turned into a sadist.
What’s the one lingering unanswered question you have about SR? I am hanging out for Joel Ellingson to go to trial so that I can find out once and for all whether redandwhite, lucydrop and Tony76 are one and the same person.
There are several people who I got to "know" by their handles who I wonder about from time to time, but mostly I hope they are safe and well and i don't want to track them down or expose them
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Eileen, I am fangirling PRE-TTY hard right now. Talking SR and Tony76 with you is how I imagine it feels to talk to a royal correspondent about Prince Andrew 😅 Ellingson being all three would be a very neat end to an otherwise insane story. Part of me wants to pin Oracle in with that trio too but that’s mostly a desperate attempt from me to add another layer to the madness. I miss the twists and turns that came with the rise and fall of SR. From your own experience - would you agree with the idea that more than one person staffed the DPR account? Thanks for the reply! Ha! You have no idea what it is like when I find someone who really knows about this stuff and can have informed conversations about it. I latch onto them and don't let go. The very BEST was meeting up with DPR's three deputies (SSBD in Australia, Inigo in US and Libertas in Ireland) so I could actually have conversations with people who knew more than I did! Variety Jones was cool too, but the conversation couldn't flow too freely thanks to him being incarcerated in Bangkok prison at the time.
I think others sometimes posted from the forum account, but Ulbricht kept a vice-like grip on his market account
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I can imagine it’s so satisfying and exciting to get those tidbits of info that piece the jigsaw together. The bedlam that played out over the forum in the aftermath was a cloud of paranoia and adrenaline that kept me refreshing pages for days. Would love to hear accounts from SSBD, Inigo and Libertas from this time. One last question: what were your thoughts when the Chloe Ayling story first broke? I assumed it was a publicity stunt. I don't think that any more. I guess I can't blame her for milking her kidnapping for publicity in the aftermath, though I don't think she does herself any favors the way she goes about it sometimes
Sorry if this has been covered before but in your research, mainly related to child abuse, where are these children coming from? Children in their care/ family? Kidnapped? The vast majority of child abuse is carried out by someone within their social circle - family and acquaintances. However, the hurtcore stuff was often carried out in third world countries on orphans or where desperate families gave up their children to "benefactors" who they believed were going to provide food an education
What Casefile episodes have you written? I became obsessed with it and ripped through all the episodes and now nothing will fill that void. Thanks for your efforts! Casefile – the murder of Amy Allwine
Casefile – Blue Skies, Black Death
Casefile – Ella Tundra
Casefile – Dnepropetrovsk Maniacs
Casefile – Motown Murders
Casefile – Rebecca Schaeffer
Casefile – Sian Kingi
Casefile – John & Mark
Casefile – Shauna Howe
Casefile – Chloe Ayling
Casefile – Johnny Altinger
Casefile – Killer Petey
Casefile – The Santa Claus Bank Robbery
Casefile – Martha Puebla
Casefile – Leigh Leigh
Is there any way parents can keep their kids safe from this without being helicopter parents? I'll cut'n'paste a response i gave to someone else about this, because it was something that really stuck out to me:
The one thing I found really interesting when I was lurking the forums of the child predators was their frustration about how children are now taught from a very young age that certain touching and acts are wrong and that they shouldn't keep certain secrets. It came up over and over again that they could not abuse certain children because they knew those children had someone they would tell. It was pretty clear that education was a child's best defence against getting abused. Kids who speak up and who have close relationships with one or more people they are likely to confide in
What does it take in terms of degrees and experience to get into this business? Nothing official. I was a lawyer, but that had no bearing on what I do now (I did corporate law). I didn't have any official credentials when I began as a freelance journalist, though later I got a diploma of professional writing and editing. Anyone can be an author, provided they can write
If you could take a guess from your findings, what would be some speculative statistics on these abuse/torture sites? How many people (tens of thousands?) are involved? Do they generally come from the same places in the world or are they seemingly geographically random (based on victim ethnicity, or language spoken, perhaps)... what are some quantifying stats to wrap our heads around how prevalent this shit is? Most dark web users come from western countries, just because infrastructure supports it. The sites often have tens of thousands of registered users, but a lot of them would be people for whom curiosity got the better of them and who signed up then left. Active users more like in the thousands, hyper-active users the hundreds.
One of the things that makes life difficult for law enforcement is that most of these sites don't operate on a commercial basis - people aren't making money from them, so there is no cryptocurrency chain to follow. They operate on a sharing basis and to get access to the more private parts of the sites, a user has to upload "fresh" material and/or prove they are actively abusing a child. Hurt2theCore used to get users to have the children hold up signs or have the site name or a username written on their bodies with a marker. This stopped law enforcement from getting access to those parts (like the "producers lounge") of the sites unless they were able to take over an account of a user who already had access. Even then, the rules of the hurtcore sites would require constant new proof in order to maintain access.
Some sites allowed people to buy access, such as one called "Welcome to Video" and then were taken down by law enforcement carrying out blockchain analysis of the Bitcoin transaction that led to the owner when they cashed out to fiat without moneylaundering precautions
the below is a reply to the above
Do you think LE uses deep fakes to simulate a picture to gain access? Is that possible? It is definitely possible, but I don't know whether they are doing it as they are understandably secretive about their methods. I know it is deeply problematic, as even fake child porn is still illegal (even cartoon stuff, including some Hentai in some countries). But they have used questionable methods before, most notably running the dark web's largest site, Playpen, for over a year in order to identify contact offenders
the below is another reply to the original answer
Am I hearing you that many people are NOT doing this for financial gain? Just to do it and share it?? Child exploitation, yes, it is mostly a sharing community. Some people make some money out of it, but it is not like drugs where a lot of people are making a LOT of money
On the subject of abused kids... did you ever help the kids in any way? I never met any of the kids. I never saw any of the photos and videos. I don't know who any of the kids are.
Daisy has been taken into care and her identity changed. I hope she is doing okay
What exactly does the dark web look like? You hear about it often, but don’t know if it looks like Google Chrome, Safari, or just a page full of code. It looks like a normal browser and operates just like a normal browser. It's just that it can access sites that your normal browser can't.
e.g. http://thehub5himseelprs44xzgfrb4obgujkqwy5tzbsh5yttebqhaau23yd.onion/index.php is the URL of a dark web forum. If you plug it into your normal browser you will get an error. If you plug it into the Tor browser you will get the registration page for The Hub
How do you keep yourself from hating all humanity? I am happy to report that, even on the dark web, the good people outnumber the bad
Hi! First off I'd like to say that I find what you do quite fascinating and would love to do something like that in the future. My question is in regards to art and other forms of artistic expression on the dark web. Is it true that the dark web is a place where you can also find awesome things such as art and literature? Not really, because all that stuff is readily available on the clearweb. There are sites like the Imperial Library of Trantor, which is a pirate site for books, where you can read thousands of books for free, but that's really no different to The Pirate Bay. Some people share their LSD art, but again, nothing you won't find on the clearweb
submitted by 500scnds to tabled [link] [comments]


2020.09.19 03:41 PaladinYami NullPointerException when calling tableView setItems

I've been smashing my face into this for a while. Time to call for help.
Inventory program for a school assignment. Main Window shows two tables. These fill properly. When selecting a product from the product table, then clicking modify, the user should be brought to the modify product window with the appropriate fields pre-filled. Instead I get a NullPointerException.

I know the error is with this line in the ModifyProductFormController: allPartsView.setItems(Inventory.getAllParts());

Product.java
/* * To change this license header, choose License Headers in Project Properties. * To change this template file, choose Tools Templates * and open the template in the editor. */ package Model; import java.lang.String; import javafx.collections.FXCollections; import javafx.collections.ObservableList; import javafx.scene.control.Alert.AlertType; import javafx.scene.control.Alert; import javafx.scene.control.ButtonType; /** * * @author howarc4 */ public class Product { ///ObservableList to contain the parts that make up this product private ObservableList associatedParts = FXCollections.observableArrayList(); //associated variables private int id; private String name; private double price; private int stock; private int min; private int max; //constructor public Product(int id, String name, double price, int stock, int min, int max) { this.id = id; this.name = name; this.price = price; this.stock = stock; this.min = min; this.max = max; } // copy constructor public Product(Product newProduct) { this.id = newProduct.getId(); this.name = newProduct.getName(); this.price = newProduct.getPrice(); this.stock = newProduct.getStock(); this.min = newProduct.getMin(); this.max = newProduct.getMax(); this.associatedParts = FXCollections.observableArrayList(newProduct.getAllAssociatedParts()); } // all setter methods /** the setId method sets the productID * @param id integer product ID */ public void setId(int id) { this.id = id; } /** the setName method sets the product name * @param name String product name */ public void setname(String name) { this.name = name; } /** the setPrice method sets the product price * @param price Price of the product */ public void setprice(int price) { this.price = price; } /** the setStock method sets the number of this product in stock * @param stock the number of this product in stock */ public void setStock(int stock) { this.stock = stock; } /** the setMin method sets the minimum number of this product to have in stock * @param min the minimum number of this product to have in stock */ public void setMin(int min) { this.min = min; } /** the setMax method sets the maximum number of this product to have in stock * @param max the maximum number of this product to have in stock */ public void setMax(int max) { this.max = max; } // All getter methods /** The getId method returns the product ID * @return the product ID */ public int getId() { return id; } /** The getName method returns the product name * @return the product name */ public String getName() { return name; } /** The getPrice method returns the product's price * @return the price of the product */ public double getPrice() { return price; } /** The getStock method returns the number of this product currently in stock * @return the number of this product currently in stock */ public int getStock() { return stock; } /** The getMin method returns the minimum number of this product to keep in stock * @return the minimum number of this product to keep in stock */ public int getMin() { return min; } /** The getMax method returns the maximum number of this product to keep in stock * @return the maximum number of this product to keep in stock */ public int getMax() { return max; } // methods dealing with associated parts /** the addAssociatePart method adds a Part object to the list of parts that make up this product * @param part the part to add */ public void addAssociatedPart(Part part) { associatedParts.add(part); } /** the deleteAssociatePart method deletes a selected part from the list of parts that make up this product * @param selectedAssociatedPart the part to be removed */ public void deleteAssociatedPart(Part selectedAssociatedPart) { associatedParts.remove(selectedAssociatedPart); } /**The getAllAssociatedParts method returns a list of the parts associated with this product * @return an observableList of the parts associated with this product. */ public ObservableList getAllAssociatedParts() { return associatedParts; } } 
MainWindowController.java
/* * To change this license header, choose License Headers in Project Properties. * To change this template file, choose Tools Templates * and open the template in the editor. */ package Controller; import Model.Inventory; import Model.Part; import Model.Product; import Controller.ModifyProductFormController; import java.io.IOException; import java.net.URL; import java.util.ResourceBundle; import java.net.URL; import java.util.ResourceBundle; import javafx.event.ActionEvent; import javafx.event.EventHandler; import javafx.fxml.FXML; import javafx.fxml.FXMLLoader; import javafx.fxml.Initializable; import javafx.scene.Parent; import javafx.scene.Scene; import javafx.scene.control.Alert; import javafx.scene.control.Button; import javafx.scene.control.ButtonType; import javafx.scene.control.Label; import javafx.scene.control.TableColumn; import javafx.scene.control.TableView; import javafx.scene.control.TextArea; import javafx.scene.control.TextField; import javafx.scene.control.cell.PropertyValueFactory; import javafx.stage.Stage; /** * FXML Controller class * * @author howarc4 */ public class MainWindowController implements Initializable { Stage stage; Parent scene; // part table view @FXML private TableView partTableView; @FXML private TableColumn partIdCol; @FXML private TableColumn partNameCol; @FXML private TableColumn partInvCol; @FXML private TableColumn partPriceCol; // part table items @FXML private Button addPartButton; @FXML private Button modifyPartButton; @FXML private Button deletePartButton; // product table view @FXML private TableColumn productIdCol; @FXML private TableView productTableView; @FXML private TableColumn productNameCol; @FXML private TableColumn productInvCol; @FXML private TableColumn productPriceCol; //Product Table panel items @FXML private TextField productSearchField; @FXML private Button addProductButton; @FXML private Button deleteProductButton; @FXML private Button modifyProductButton; @FXML private Button exitButton; String confirmDeletePart; String confirmDeleteProduct; String partDeletedSuccess; String productDeletedSuccess; String partDeleteCancelled; String productDeleteCancelled; String errorNoPartSelected = "Please select a part."; String errorNoProductSelected = "Please select a product."; String errorProductHasParts = "This product cannot be delected because it has parts associated with it."; private static Product passingProduct = null; public static Product getPassingProduct() { System.out.println("entered getPassingProduct method in mainwindowcontroller"); return passingProduct; } @FXML void onActionAddPart(ActionEvent event) throws IOException { stage = (Stage)((Button)event.getSource()).getScene().getWindow(); scene = FXMLLoader.load(getClass().getResource("/view/AddPartForm.fxml")); stage.setScene(new Scene(scene)); stage.show(); } @FXML void onActionModifyPart(ActionEvent event) throws IOException { stage = (Stage)((Button)event.getSource()).getScene().getWindow(); scene = FXMLLoader.load(getClass().getResource("/view/ModifyPartForm.fxml")); stage.setScene(new Scene(scene)); stage.show(); } @FXML void onActionDeletePart(ActionEvent event) throws IOException { //System.out.println("delete part button pressed"); // Check that a part was selected if(partTableView.getSelectionModel().getSelectedItem() == null) { Alert noPartSelectedAlert = new Alert(Alert.AlertType.ERROR, errorNoPartSelected, ButtonType.OK); noPartSelectedAlert.show(); return; } // Get the selected part and it's name Part selectedPart = partTableView.getSelectionModel().getSelectedItem(); String selectedPartName = selectedPart.getName(); confirmDeletePart = "Are you sure you want to delete part " + selectedPartName + "?"; Alert alertDeletePart = new Alert(Alert.AlertType.CONFIRMATION, confirmDeletePart, ButtonType.YES, ButtonType.CANCEL); alertDeletePart.showAndWait(); if(alertDeletePart.getResult() == ButtonType.YES) { Inventory.deletePart(selectedPart); partDeletedSuccess = selectedPartName + " was deleted."; Alert partDeletedAlert = new Alert(Alert.AlertType.INFORMATION, partDeletedSuccess, ButtonType.OK); partDeletedAlert.show(); } else if(alertDeletePart.getResult() == ButtonType.CANCEL) { partDeleteCancelled = "Deletion of " + selectedPartName + " cancelled."; Alert partDeleteCancelledAlert = new Alert(Alert.AlertType.INFORMATION, partDeleteCancelled, ButtonType.OK); partDeleteCancelledAlert.show(); } } @FXML void onActionAddProduct(ActionEvent event) throws IOException { stage = (Stage)((Button)event.getSource()).getScene().getWindow(); scene = FXMLLoader.load(getClass().getResource("/view/AddProductForm.fxml")); stage.setScene(new Scene(scene)); stage.show(); } @FXML void onActionModifyProduct(ActionEvent event) throws IOException { // Check that a part was selected if(productTableView.getSelectionModel().getSelectedItem() == null) { Alert noProductSelectedAlert = new Alert(Alert.AlertType.ERROR, errorNoProductSelected, ButtonType.OK); noProductSelectedAlert.show(); return; } // pass the product to the modifyProduct screen's controller ModifyProductFormController.passProduct(productTableView.getSelectionModel().getSelectedItem()); System.out.println("Called the passProduct method"); // set up and show the modifyProduct screen stage = (Stage)((Button)event.getSource()).getScene().getWindow(); System.out.println("set the stage"); scene = FXMLLoader.load(getClass().getResource("/view/ModifyProductForm.fxml")); System.out.println("called the fxmlloader"); stage.setScene(new Scene(scene)); stage.show(); } @FXML void onActionDeleteProduct(ActionEvent event) throws IOException { // Check that a part was selected if(productTableView.getSelectionModel().getSelectedItem() == null) { Alert noProductSelectedAlert = new Alert(Alert.AlertType.ERROR, errorNoProductSelected, ButtonType.OK); noProductSelectedAlert.show(); return; } // Get the selected part and it's name Product selectedProduct = productTableView.getSelectionModel().getSelectedItem(); String selectedProductName = selectedProduct.getName(); confirmDeleteProduct = "Are you sure you want to delete part " + selectedProductName + "?"; Alert alertDeleteProduct = new Alert(Alert.AlertType.CONFIRMATION, confirmDeleteProduct, ButtonType.YES, ButtonType.CANCEL); alertDeleteProduct.showAndWait(); if(alertDeleteProduct.getResult() == ButtonType.YES) { Inventory.deleteProduct(selectedProduct); productDeletedSuccess = selectedProductName + " was deleted."; Alert productDeletedAlert = new Alert(Alert.AlertType.INFORMATION, productDeletedSuccess, ButtonType.OK); productDeletedAlert.show(); } else if(alertDeleteProduct.getResult() == ButtonType.CANCEL) { productDeleteCancelled = "Deletion of " + selectedProductName + " cancelled."; Alert productDeleteCancelledAlert = new Alert(Alert.AlertType.INFORMATION, productDeleteCancelled, ButtonType.OK); productDeleteCancelledAlert.show(); } } @FXML void onActionExit(ActionEvent event) { System.exit(0); } /** * Initializes the controller class. * @param url the url * @param rb the resourcebundle */ @Override public void initialize(URL url, ResourceBundle rb) { // TODO //create and fill part table partTableView.setItems(Inventory.getAllParts()); partIdCol.setCellValueFactory(new PropertyValueFactory<>("Id")); partNameCol.setCellValueFactory(new PropertyValueFactory<>("Name")); partInvCol.setCellValueFactory(new PropertyValueFactory<>("Stock")); partPriceCol.setCellValueFactory(new PropertyValueFactory<>("Price")); //create and fill Product table productTableView.setItems(Inventory.getAllProducts()); productIdCol.setCellValueFactory(new PropertyValueFactory<>("Id")); productNameCol.setCellValueFactory(new PropertyValueFactory<>("Name")); productInvCol.setCellValueFactory(new PropertyValueFactory<>("Stock")); productPriceCol.setCellValueFactory(new PropertyValueFactory<>("Price")); } } 
MainWindow.fxml
           
ModifyProductFormController.java
/* * To change this license header, choose License Headers in Project Properties. * To change this template file, choose Tools Templates * and open the template in the editor. */ package Controller; import Model.Inventory; import Model.Part; import Model.Product; import java.io.IOException; import java.net.URL; import java.util.InputMismatchException; import java.util.ResourceBundle; import javafx.collections.FXCollections; import javafx.collections.ObservableList; import javafx.event.ActionEvent; import javafx.fxml.FXML; import javafx.fxml.FXMLLoader; import javafx.fxml.Initializable; import javafx.scene.Parent; import javafx.scene.Scene; import javafx.scene.control.Alert; import javafx.scene.control.Button; import javafx.scene.control.ButtonType; import javafx.scene.control.TableColumn; import javafx.scene.control.TableView; import javafx.scene.control.TextField; import javafx.scene.control.cell.PropertyValueFactory; import javafx.stage.Stage; /** * FXML Controller class * * @author howarc4 */ public class ModifyProductFormController implements Initializable { Stage stage; Parent scene; //the product to be modified private static Product selectedProduct; private static int selectedProductIndex; // set up allPartsView @FXML private static TableView allPartsView; @FXML private TableColumn allPartsIdCol; @FXML private TableColumn allPartsNameCol; @FXML private TableColumn allPartsInvCol; @FXML private TableColumn allPartsPriceCol; // set up selectedPartsView @FXML private static TableView selectedPartsView; @FXML private TableColumn selectedPartsIdCol; @FXML private TableColumn selectedPartsNameCol; @FXML private TableColumn selectedPartsInvCol; @FXML private TableColumn selectedPartsPriceCol; private static ObservableList selectedParts; @FXML private TextField searchField; // Product attribute text fields @FXML private TextField productIdField; @FXML private TextField productNameField; @FXML private TextField productPriceField; @FXML private TextField productInvField; @FXML private TextField productMaxField; @FXML private TextField productMinField; /** * The initData method accepts a product to be modified and initializes the data fields * @param product the product to be modified */ public static void passProduct(Product product) { System.out.println("passProduct reached"); selectedProductIndex = Inventory.getAllProducts().indexOf(product); selectedProduct = product; System.out.println("passProduct completed"); System.out.println(selectedProduct.getName()); } @FXML void onActionAddPartToProduct(ActionEvent event) { selectedParts.add(allPartsView.getSelectionModel().getSelectedItem()); } @FXML void onActionRemoveAssociatedPart(ActionEvent event) { selectedParts.remove(allPartsView.getSelectionModel().getSelectedItem()); } @FXML void onActionSaveProduct(ActionEvent event) { // get the values of all fields and convert to their appropriate types String newProductName = productNameField.getText(); int newProductInv; int newProductMin; int newProductMax; double newProductPrice; // for all data types other than String, check for valid input types try { newProductInv = Integer.parseInt(productInvField.getText()); } catch(InputMismatchException e) { Alert invalidInventoryAlert = new Alert(Alert.AlertType.ERROR, "Please enter an integer value for the current product stock.", ButtonType.OK); invalidInventoryAlert.show(); return; } try { newProductMin = Integer.parseInt(productMinField.getText()); } catch(InputMismatchException e) { Alert invalidMinAlert = new Alert(Alert.AlertType.ERROR, "Please enter an integer value for the minimum product stock.", ButtonType.OK); invalidMinAlert.show(); return; } try { newProductMax = Integer.parseInt(productMaxField.getText()); } catch(InputMismatchException e) { Alert invalidMaxAlert = new Alert(Alert.AlertType.ERROR, "Please enter an integer value for the maximum product stock.", ButtonType.OK); invalidMaxAlert.show(); return; } try { newProductPrice = Double.parseDouble(productPriceField.getText()); } catch(InputMismatchException e) { Alert invalidPriceAlert = new Alert(Alert.AlertType.ERROR, "Please enter the price as a decimal value EX: 4.95", ButtonType.OK); invalidPriceAlert.show(); return; } // check for null value in product name, and default 0 values in other attributes except minimum inventory // if any are null or 0, request user fill in all fields and return if(newProductName == null newProductPrice == 0.0 newProductInv == 0 newProductMax == 0) { Alert blankValuesAlert = new Alert(Alert.AlertType.ERROR, "Please fill in all fields.", ButtonType.OK); blankValuesAlert.show(); return; } // create the updated product object Product updatedProduct = new Product(selectedProductIndex, newProductName, newProductPrice, newProductInv, newProductMin, newProductMax); // pass the updated product object into the allProducts list to replace the previous version Inventory.updateProduct(selectedProductIndex, updatedProduct); } @FXML void onActionCancel(ActionEvent event) throws IOException { // when the cancel button is pressed, return to the main screen stage = (Stage)((Button)event.getSource()).getScene().getWindow(); scene = FXMLLoader.load(getClass().getResource("/view/MainWindow.fxml")); stage.setScene(new Scene(scene)); stage.show(); } /** * Initializes the controller class. * @param url the url * @param rb the resourcebundle */ @Override public void initialize(URL url, ResourceBundle rb) { // TODO System.out.println("Entered the initializer on ModifyProductFormController"); //selectedProduct = new Product(MainWindowController.getPassingProduct()); //System.out.println("selectedProduct = " + selectedProduct.getName()); // populare selectedparts with the product's associated parts selectedParts = FXCollections.observableArrayList(selectedProduct.getAllAssociatedParts()); System.out.println("selectedParts array list made"); // populate allParts table view allPartsView.setItems(Inventory.getAllParts()); System.out.println("allPartsView set items"); allPartsIdCol.setCellValueFactory(new PropertyValueFactory<>("Id")); allPartsNameCol.setCellValueFactory(new PropertyValueFactory<>("Name")); allPartsInvCol.setCellValueFactory(new PropertyValueFactory<>("Stock")); allPartsPriceCol.setCellValueFactory(new PropertyValueFactory<>("Price")); System.out.println("allpartsview built"); // populate selectedParts table view with this products associated parts selectedPartsView.setItems(selectedParts); selectedPartsIdCol.setCellValueFactory(new PropertyValueFactory<>("Id")); selectedPartsNameCol.setCellValueFactory(new PropertyValueFactory<>("Name")); selectedPartsInvCol.setCellValueFactory(new PropertyValueFactory<>("Stock")); selectedPartsPriceCol.setCellValueFactory(new PropertyValueFactory<>("Price")); System.out.println("selectedpartsview built"); // fill product attribute fields with product's existing attributes productIdField.setText(Integer.toString(selectedProduct.getId())); System.out.println("id field filled"); productNameField.setText(selectedProduct.getName()); System.out.println("name field filled"); productPriceField.setText(Double.toString(selectedProduct.getPrice())); System.out.println("price field filled"); productInvField.setText(Integer.toString(selectedProduct.getStock())); System.out.println("stock field filled"); productMaxField.setText(Integer.toString(selectedProduct.getMin())); System.out.println("min field filled"); productMinField.setText(Integer.toString(selectedProduct.getMax())); System.out.println("max field filled"); } } 
Output
ant -f C:\\Users\\howarc4\\Documents\\NetBeansProjects\\Inventory -Dnb.internal.action.name=run run init: Deleting: C:\Users\howarc4\Documents\NetBeansProjects\Inventory\build\built-jar.properties deps-jar: Updating property file: C:\Users\howarc4\Documents\NetBeansProjects\Inventory\build\built-jar.properties Compiling 1 source file to C:\Users\howarc4\Documents\NetBeansProjects\Inventory\build\classes compile: run: passProduct reached passProduct completed testProduct1 Called the passProduct method set the stage Entered the initializer on ModifyProductFormController selectedParts array list made allpartsview built Exception in thread "JavaFX Application Thread" java.lang.RuntimeException: java.lang.reflect.InvocationTargetException at javafx.fxml/javafx.fxml.FXMLLoader$MethodHandler.invoke(FXMLLoader.java:1787) at javafx.fxml/javafx.fxml.FXMLLoader$ControllerMethodEventHandler.handle(FXMLLoader.java:1670) at javafx.base/com.sun.javafx.event.CompositeEventHandler.dispatchBubblingEvent(CompositeEventHandler.java:86) at javafx.base/com.sun.javafx.event.EventHandlerManager.dispatchBubblingEvent(EventHandlerManager.java:238) at javafx.base/com.sun.javafx.event.EventHandlerManager.dispatchBubblingEvent(EventHandlerManager.java:191) at javafx.base/com.sun.javafx.event.CompositeEventDispatcher.dispatchBubblingEvent(CompositeEventDispatcher.java:59) at javafx.base/com.sun.javafx.event.BasicEventDispatcher.dispatchEvent(BasicEventDispatcher.java:58) at javafx.base/com.sun.javafx.event.EventDispatchChainImpl.dispatchEvent(EventDispatchChainImpl.java:114) at javafx.base/com.sun.javafx.event.BasicEventDispatcher.dispatchEvent(BasicEventDispatcher.java:56) at javafx.base/com.sun.javafx.event.EventDispatchChainImpl.dispatchEvent(EventDispatchChainImpl.java:114) at javafx.base/com.sun.javafx.event.BasicEventDispatcher.dispatchEvent(BasicEventDispatcher.java:56) at javafx.base/com.sun.javafx.event.EventDispatchChainImpl.dispatchEvent(EventDispatchChainImpl.java:114) at javafx.base/com.sun.javafx.event.EventUtil.fireEventImpl(EventUtil.java:74) at javafx.base/com.sun.javafx.event.EventUtil.fireEvent(EventUtil.java:49) at javafx.base/javafx.event.Event.fireEvent(Event.java:198) at javafx.graphics/javafx.scene.Node.fireEvent(Node.java:8879) at javafx.controls/javafx.scene.control.Button.fire(Button.java:200) at javafx.controls/com.sun.javafx.scene.control.behavior.ButtonBehavior.mouseReleased(ButtonBehavior.java:206) at javafx.controls/com.sun.javafx.scene.control.inputmap.InputMap.handle(InputMap.java:274) at javafx.base/com.sun.javafx.event.CompositeEventHandler$NormalEventHandlerRecord.handleBubblingEvent(CompositeEventHandler.java:218) at javafx.base/com.sun.javafx.event.CompositeEventHandler.dispatchBubblingEvent(CompositeEventHandler.java:80) at javafx.base/com.sun.javafx.event.EventHandlerManager.dispatchBubblingEvent(EventHandlerManager.java:238) at javafx.base/com.sun.javafx.event.EventHandlerManager.dispatchBubblingEvent(EventHandlerManager.java:191) at javafx.base/com.sun.javafx.event.CompositeEventDispatcher.dispatchBubblingEvent(CompositeEventDispatcher.java:59) at javafx.base/com.sun.javafx.event.BasicEventDispatcher.dispatchEvent(BasicEventDispatcher.java:58) at javafx.base/com.sun.javafx.event.EventDispatchChainImpl.dispatchEvent(EventDispatchChainImpl.java:114) at javafx.base/com.sun.javafx.event.BasicEventDispatcher.dispatchEvent(BasicEventDispatcher.java:56) at javafx.base/com.sun.javafx.event.EventDispatchChainImpl.dispatchEvent(EventDispatchChainImpl.java:114) at javafx.base/com.sun.javafx.event.BasicEventDispatcher.dispatchEvent(BasicEventDispatcher.java:56) at javafx.base/com.sun.javafx.event.EventDispatchChainImpl.dispatchEvent(EventDispatchChainImpl.java:114) at javafx.base/com.sun.javafx.event.EventUtil.fireEventImpl(EventUtil.java:74) at javafx.base/com.sun.javafx.event.EventUtil.fireEvent(EventUtil.java:54) at javafx.base/javafx.event.Event.fireEvent(Event.java:198) at javafx.graphics/javafx.scene.Scene$MouseHandler.process(Scene.java:3851) at javafx.graphics/javafx.scene.Scene$MouseHandler.access$1200(Scene.java:3579) at javafx.graphics/javafx.scene.Scene.processMouseEvent(Scene.java:1849) at javafx.graphics/javafx.scene.Scene$ScenePeerListener.mouseEvent(Scene.java:2588) at javafx.graphics/com.sun.javafx.tk.quantum.GlassViewEventHandler$MouseEventNotification.run(GlassViewEventHandler.java:397) at javafx.graphics/com.sun.javafx.tk.quantum.GlassViewEventHandler$MouseEventNotification.run(GlassViewEventHandler.java:295) at java.base/java.security.AccessController.doPrivileged(Native Method) at javafx.graphics/com.sun.javafx.tk.quantum.GlassViewEventHandler.lambda$handleMouseEvent$2(GlassViewEventHandler.java:434) at javafx.graphics/com.sun.javafx.tk.quantum.QuantumToolkit.runWithoutRenderLock(QuantumToolkit.java:390) at javafx.graphics/com.sun.javafx.tk.quantum.GlassViewEventHandler.handleMouseEvent(GlassViewEventHandler.java:433) at javafx.graphics/com.sun.glass.ui.View.handleMouseEvent(View.java:556) at javafx.graphics/com.sun.glass.ui.View.notifyMouse(View.java:942) at javafx.graphics/com.sun.glass.ui.win.WinApplication._runLoop(Native Method) at javafx.graphics/com.sun.glass.ui.win.WinApplication.lambda$runLoop$3(WinApplication.java:174) at java.base/java.lang.Thread.run(Thread.java:834) Caused by: java.lang.reflect.InvocationTargetException at java.base/jdk.internal.reflect.NativeMethodAccessorImpl.invoke0(Native Method) at java.base/jdk.internal.reflect.NativeMethodAccessorImpl.invoke(NativeMethodAccessorImpl.java:62) at java.base/jdk.internal.reflect.DelegatingMethodAccessorImpl.invoke(DelegatingMethodAccessorImpl.java:43) at java.base/java.lang.reflect.Method.invoke(Method.java:566) at com.sun.javafx.reflect.Trampoline.invoke(MethodUtil.java:76) at jdk.internal.reflect.GeneratedMethodAccessor2.invoke(Unknown Source) at java.base/jdk.internal.reflect.DelegatingMethodAccessorImpl.invoke(DelegatingMethodAccessorImpl.java:43) at java.base/java.lang.reflect.Method.invoke(Method.java:566) at javafx.base/com.sun.javafx.reflect.MethodUtil.invoke(MethodUtil.java:273) at javafx.fxml/com.sun.javafx.fxml.MethodHelper.invoke(MethodHelper.java:83) at javafx.fxml/javafx.fxml.FXMLLoader$MethodHandler.invoke(FXMLLoader.java:1782) ... 47 more Caused by: javafx.fxml.LoadException: /C:/Users/howarc4/Documents/NetBeansProjects/Inventory/build/classes/view/ModifyProductForm.fxml at javafx.fxml/javafx.fxml.FXMLLoader.constructLoadException(FXMLLoader.java:2625) at javafx.fxml/javafx.fxml.FXMLLoader.loadImpl(FXMLLoader.java:2603) at javafx.fxml/javafx.fxml.FXMLLoader.loadImpl(FXMLLoader.java:2466) at javafx.fxml/javafx.fxml.FXMLLoader.loadImpl(FXMLLoader.java:3237) at javafx.fxml/javafx.fxml.FXMLLoader.loadImpl(FXMLLoader.java:3194) at javafx.fxml/javafx.fxml.FXMLLoader.loadImpl(FXMLLoader.java:3163) at javafx.fxml/javafx.fxml.FXMLLoader.loadImpl(FXMLLoader.java:3136) at javafx.fxml/javafx.fxml.FXMLLoader.loadImpl(FXMLLoader.java:3113) at javafx.fxml/javafx.fxml.FXMLLoader.load(FXMLLoader.java:3106) at Controller.MainWindowController.onActionModifyProduct(MainWindowController.java:192) ... 58 more Caused by: java.lang.NullPointerException at Controller.ModifyProductFormController.initialize(ModifyProductFormController.java:228) at javafx.fxml/javafx.fxml.FXMLLoader.loadImpl(FXMLLoader.java:2573) ... 66 more BUILD SUCCESSFUL (total time: 28 seconds) 
submitted by PaladinYami to JavaFX [link] [comments]


2020.09.17 01:05 AnimeMod Serial Experiments Lain - Thursday Anime Discussion Thread (ft. r/anime Writing Club)

Hi! Welcome to another edition of the weekly Thursday Anime Discussion Thread, featuring us, the anime Writing Club. We simulwatch anime TV series and movies together once a month, so check us out if you'd like to participate. Our thoughts on the series, as always, are covered below. :)
Today we are covering...

Serial Experiments Lain

Lain Iwakura, an awkward and introverted fourteen-year-old, is one of the many girls from her school to receive a disturbing email from her classmate Chisa Yomoda—the very same Chisa who recently committed suicide. Lain has neither the desire nor the experience to handle even basic technology; yet, when the technophobe opens the email, it leads her straight into the Wired, a virtual world of communication networks similar to what we know as the internet. Lain's life is turned upside down as she begins to encounter cryptic mysteries one after another. Strange men called the Men in Black begin to appear wherever she goes, asking her questions and somehow knowing more about her than even she herself knows. With the boundaries between reality and cyberspace rapidly blurring, Lain is plunged into more surreal and bizarre events where identity, consciousness, and perception are concepts that take on new meanings.
Written by Chiaki J. Konaka, whose other works include Texhnolyze, Serial Experiments Lain is a psychological avant-garde mystery series that follows Lain as she makes crucial choices that will affect both the real world and the Wired. In closing one world and opening another, only Lain will realize the significance of their presence.
Written by MAL Rewrite

"Watch This!" posts

[WT! Serial Experiments Lain]
Looking for more "Watch This!" posts? Check the "Watch This!" archive!

Databases

AniDB AniList AnimeNewsNetwork MyAnimeList

Groupwatch prompts and thoughts

1) What are your thoughts on the ways in which the show engages with the concept of The Wired itself

It is a pathway for the flow of information
Rather than try and predict exactly how the internet would end up being, which would have been a difficult task in 1998, the show chose to comment on the nature of the internet and what it is at a fundamental level. Lain posits that The Wired is a pathway for the flow of information. Our existence is simply a flow of information, and so our presence in The Wired is therefore part of our existence. The Wired exists as a layer of our reality and what we do there is part of who we are and can affect the world around us. Naturally our posting on the internet doesn’t render nearly as dramatic results as use of The Wired does in Lain, but at a base level the concept is the same.
[isrozzis]
A conduit through which to explore the main concepts
The Wired simply served as a the perfect conduit through which to explore several of the concepts and themes present in the series thanks to the ease with which those concepts could be interpreted through a technological lens, with aspects of The Wired making for excellent parallels to paranormal phenomena, interpersonal relationships, a higher plane, and the flow and malleability of knowledge. Lain isn't a super detailed and focused commentary on the nature of the internet in the same way that Patlabor's first movie deals with computer viruses or Ghost in the Shell on AI. The creators did a good job using The Wired as a vector for presenting the show's horror and later philosophical themes. In this way it could be similar to mecha shows where the mecha are incredibly cool and flashy yet secondary in importance.
[Pixelsaber RX-Nota-II]
An auxiliary yet fascinating draw for the show
I'll readily admit the show isn't about The Wired, but it's my favorite part of the show. There's a nerdiness that explodes when Konaka talks about The Wired that's missing from the rest. The bits and pecks of C code, references to HAL 9000 and the Mac, the simple talks about upgrading a Navi - absent in any other show. Hard to find anime much less art willing to delve into the cold calculated cosmos of computing. Did it have to be a computer? No, it could be an experience; some object or some vision. But the integration of computers into the plot lends a timelessness, which only makes the messages of the show more important in the era of social media.
[west_virginia_pine]

2) "Present Day, Present Time" does Lain successfully manage to stay relevant to this day?

The series' timeless qualities with humanity at its core keep it relevant
It’s not so much that the series managed to be incredibly prescient in its speculative fiction elements, since much of what it asserts will transpire with the proliferation of the internet as displayed in the series was already underway at the time, rather it’s in the careful handling of the series’ evergreen themes that it attains this quality of relevance. One of the most interesting things Lain discusses is information; if a being had access to and control of all the information possessed by humanity collectively, would that person be distinguishable from God? Everything humans do is a result of electric impulses in the nervous system. We are as governed by the flow of information as they are. The show is timeless because of the human messages at its core - finding a sense of self and reaching out to people - more relevant as we lose ourselves in the mire of mass media. The show has a reputation for its cold existentialism but there's warm positive love at its heart.
[Pixelsaber krasnovian west_virgnia_pine]
Our increasingly digital lives make Lain more relevant then ever
The quote was really striking every episode, it was a constant reminder that stuck with us for the most part. Despite some clear technical and aesthetic elements, Lain feels like it could be just as easily be set today. One thing that stuck out to me was how easily one could understand how the whole space with The Wired worked when applying our understanding of the internet today. Our lives are connected via the internet more now than ever, especially with the current global pandemic, which makes the messages in the show resonate strongly with our present day and present time. Lain’s central theme is about the relationship between ourselves and our digital lives. It seems clear that what we do online is very much a part of us, or at the very least is never gone and can be dredged out of the depths of the internet to haunt us years later when we wish it didn’t exist. This happens daily and ranges from simple stuff like finding some old pictures on facebook to having things someone said years ago surface and ruin their careers. Present Day, Present Time is a little cheesy, but it really does capture the spirit of what is going on.
[ValkyrieCain9 isrozzis max_turner]
A focus on advanced 90's technology dates the show
The focus on contemporary technology really dates the show pretty hard in a way that more fantastical tech shows like mecha or futuristic anime aren't affected by. A giant robot or cyborg doesn't feel particularly old as they never really existed but seeing stacked CRTs, giant keyboard cell phones, classic Apple gear, and Lain's server room gives me a constant reminder that this stuff is quite old. The daily reminder explicitly calling out "Present day, Present Time" was necessary to tell me that this was supposed to feel cutting edge and really advanced. One wonders if the creators knew this and partly included the callout to counteract the chosen aesthetic that had no way of aging gracefully.
[RX-Nota-II]

3) What do you think of the role mental illness plays in this show?

A superb groundwork that is too quickly left behind
The series’ use of mental illnesses, or the appropriate equivalents for an entity of The Wired, is quite integral to the development of its mounting intrigue and is the reason the series is able to mete out it’s narrative in a suitably measured manner. It is also a suitably human element that helps the viewer more keenly sympathize with Lain, something which would have been difficult if a different stand-in element had been utilized instead. It is well done showing struggles with the disorder that feel surprisingly real, yet they dismiss it pretty suddenly as the show's brisk pacing focuses more on the superhuman. This is a shame since the groundwork laid to make a more interesting storyline based on the trauma is already there and it is not taken for the sake of either limited episode counts or a preferred pacing to get to the supernatural.
[Pixelsaber RX-Nota-II]
An accurate reflection of real illness that sets up the philosophical questions raised in the later half
I have a close family member who lives with schizophrenia, including auditory hallucinations. It’s made me consider the line between perception and reality in the same way Lain does. Lain addresses some of principles of solipsism but in the end rejects it as a valid model for viewing the world; perceiving something doesn’t mean that it’s real and not perceiving things does not eliminate its existence. From my admittedly secondhand understanding of my family member’s condition, Lain’s experience with The Wired captures certain elements of the experience quite accurately.
[krasnovian]
Not the most important aspect
The show doesn’t comment much on mental illness. The focus of the show is almost entirely on technology, how we interact with it, and what our relationship with our digital lives is. While there are depictions of mental health struggles in the show it doesn’t appear that the show is intentionally commenting on them. What is in the show is used to support our relationship with technology or is simply a plot device. It would be best to say that rather than Lain being depressed, it’s Lain grappling with the duality of her existence and the fact that maybe she’s not even human to begin with. There’s a lot to take in there.
[isrozzis]

4) What do you make of Lain’s path towards self-realization and how it is interlaced with her relationship with divinity?

Lain's humanity in the face of new development leads her to rediscover her divinity
Lain’s process of rediscovery and self-realization is notably punctuated, occuring in relation to revelations pertaining to the ongoing narrative, which Lain always reacts to in reasonable ways as a character, pushing her away from her fabricated existence and back into the role she had seemingly once occupied. It’s the interplay between Lain’s ‘known’ and unknown facets that is most interesting, as it is through her humanity that she often comes to not only learn more of herself in spite of her true nature. It’s the fact these understandably human actions and moments lead to Lain further isolating herself, putting herself in a position to be further exposed to her own divinity and the elements of The Wired, which indicates the necessity of both her humanity and inaction in her role as a godly entity of The Wired, posing interesting considerations as to the series’ concept of transhumanism.
[Pixelsaber]
A wild thriller that slowly converges to reveal the truth
This really is the bread and butter of Lain. The intersection of self realization and divinity creates a great opportunity for the thriller and mystery aspects of the show as all the revelations make sense yet seem totally unpredictable. The use of dissociative personalities here to create confusion and a gradual path towards reality was great. It plays perfectly with the wildly different ideas of divinity that arise from the kids gesturing to the sky to phantoms in the club to Eiri Masami as quite a standard looking anime villain. Further developing the answer towards the question of Lain's identity gets matched perfectly with a clearer idea of what a divine being truly is and the two paths eventually merge into a single universal answer: she is just a being that is omnipresent.
[RX-Nota-II]

5) The writer commented saying Alice in Lain is very similar to the Alice from Lewis Carol’s Alice in Wonderland. Do you agree or disagree with that statement?

Enough is there for an uninformed viewer to justify a similarity
With only some cursory familiarity to the story of Alice in Wonderland, some passing resemblance between the two characters can be still observed. Both Alices end up descending into a world that is unknown but somewhat familiar in pursuit of someone else. Book Alice’s traipse through Wonderland ends up being naught but a dream, and although us the viewers know that the events which transpired in the series where as real as can be managed, Alice’s knowledge of the events and of Lain’s existence post-reset is not unlike the faded traces of a forgotten dream.
[Pixelsaber]
it is the titular characters of both works which makes for a proper comparison
Alice in Wonderland’s basic plot can be found in many other stories and Lain does not seem to be an exception to this. The story of a girl who finds herself in a new and fascinating world and by taking a journey through it comes to learn about the world and herself, is something seen clearly in Lain. Though we would argue that this story line fits more with Lain than with Alice. For one, Lain’s room becomes a sort of physical manifestation of the “wonderland” of The Wired as she gets sucked further into it. There are also several close ties to see in each of the plots. There is some sort of call to this world. For Alice it was the white rabbit in a waistcoat and for Lain it was the messages she received from Chisa. Alice finds herself in different precarious situations being caused as well as aided by “eat me” and “drink me” biscuits and potions in order to alter her physical form, while Lain enters The Wired by abandoning her physical form altogether, both of which leave the girls with very little sense of self. And the question of ‘Who am I?’ is not just something that nags at them but can also be seen in their interactions with other people, some who are just as curious as they are like the giant caterpillar smoking a hookah, while claiming to know who they are, like the kids at Cyberia. Alice in Wonderland’s plot is very basic at its core and so it transfers really well to other stories while still allowing the stories to be just as unique like with Lain, but also comparing Lain to Alice in Wonderland helps to ground it in something a lot more familiar for some.
[ValkyrieCain9]

6) What is your interpretation of the rock/jazz free form section of the first half of episode 11?

The recap emphasizes the authentic feelings evoked by memories even if they are lies
The segment begins with a frame of text: "Memory isn't something so vague" then dives straight into a quite a straightforward recap. This is clearly a rejection or an attempt to reject Eiri's assertion that Lain's memories are a lie. Lain wants to prove that her memories aren't vague, they are real, and that her relationships are also real. Interestingly the word used for vague here is 曖昧 which has a letter quite similar to the Japanese for love 愛. The recap blitz then ends on a text screen showing 'aliceLOVE needs you' along with some nonsense Japanese text saying something poetic about a loving heart. The bookends clearly want to emphasize the love Lain sees even though there are plenty of memories flashed in that have nothing to do with that side of the show. The moments she had with Alice were real, the feelings she had towards Alice were real, and the connection she shared with Alice and everyone else she encountered was undoubtedly real.
[RX-Nota-II max_turner]
Undoubtedly Iconic. Frustratingly mysterious
At surface level the nearly eleven minute free form rock/jazz odyssey is a recap of events that have happened over the show that is explained away as Lain installing an emulator of Navi into herself and that resulting in information overload, but it strikes me odd that Lain would do that without a reason so perhaps that’s not the sole reason. The choice of music stands out to me in particular, as the show is heavily rooted in the denpa aesthetic which does not really lend itself to jazz and rock. Jazz is very free flowing with few rules and restrictions which is possibly used to show the free flow of information into Lain at this moment. Ultimately it is difficult to really pin down why this section exists, and yet it’s always seen as an iconic part of the show.
[isrozzis]
Remember that any information not found early in the show itself is considered a spoiler. Please properly tag spoilers!
Or else...

Next week's anime discussion thread: Death;Note

Further information about past and upcoming discussions can be found on the Weekly Discussion wiki page.
Check out anime Writing Club's wiki page Please PM u/DrJWilson for any concerns or interest in joining the club!
submitted by AnimeMod to anime [link] [comments]


2020.09.16 22:16 RX-Nota-II Serial Experiments Lain - Thursday Anime Discussion Thread (ft. r/anime Writing Club)

Hi! Welcome to another edition of the weekly Thursday Anime Discussion Thread, featuring us, the anime Writing Club. We simulwatch anime TV series and movies together once a month, so check us out if you'd like to participate. Our thoughts on the series, as always, are covered below. :)
Today we are covering...

Serial Experiments Lain

Lain Iwakura, an awkward and introverted fourteen-year-old, is one of the many girls from her school to receive a disturbing email from her classmate Chisa Yomoda—the very same Chisa who recently committed suicide. Lain has neither the desire nor the experience to handle even basic technology; yet, when the technophobe opens the email, it leads her straight into the Wired, a virtual world of communication networks similar to what we know as the internet. Lain's life is turned upside down as she begins to encounter cryptic mysteries one after another. Strange men called the Men in Black begin to appear wherever she goes, asking her questions and somehow knowing more about her than even she herself knows. With the boundaries between reality and cyberspace rapidly blurring, Lain is plunged into more surreal and bizarre events where identity, consciousness, and perception are concepts that take on new meanings.
Written by Chiaki J. Konaka, whose other works include Texhnolyze, Serial Experiments Lain is a psychological avant-garde mystery series that follows Lain as she makes crucial choices that will affect both the real world and the Wired. In closing one world and opening another, only Lain will realize the significance of their presence.
Written by MAL Rewrite

"Watch This!" posts

[WT! Serial Experiments Lain]
Looking for more "Watch This!" posts? Check the "Watch This!" archive!

Databases

AniDB AniList AnimeNewsNetwork MyAnimeList

Groupwatch prompts and thoughts

1) What are your thoughts on the ways in which the show engages with the concept of The Wired itself

It is a pathway for the flow of information
Rather than try and predict exactly how the internet would end up being, which would have been a difficult task in 1998, the show chose to comment on the nature of the internet and what it is at a fundamental level. Lain posits that The Wired is a pathway for the flow of information. Our existence is simply a flow of information, and so our presence in The Wired is therefore part of our existence. The Wired exists as a layer of our reality and what we do there is part of who we are and can affect the world around us. Naturally our posting on the internet doesn’t render nearly as dramatic results as use of The Wired does in Lain, but at a base level the concept is the same.
[isrozzis]
A conduit through which to explore the main concepts
The Wired simply served as a the perfect conduit through which to explore several of the concepts and themes present in the series thanks to the ease with which those concepts could be interpreted through a technological lens, with aspects of The Wired making for excellent parallels to paranormal phenomena, interpersonal relationships, a higher plane, and the flow and malleability of knowledge. Lain isn't a super detailed and focused commentary on the nature of the internet in the same way that Patlabor's first movie deals with computer viruses or Ghost in the Shell on AI. The creators did a good job using The Wired as a vector for presenting the show's horror and later philosophical themes. In this way it could be similar to mecha shows where the mecha are incredibly cool and flashy yet secondary in importance.
[Pixelsaber RX-Nota-II]
An auxiliary yet fascinating draw for the show
I'll readily admit the show isn't about The Wired, but it's my favorite part of the show. There's a nerdiness that explodes when Konaka talks about The Wired that's missing from the rest. The bits and pecks of C code, references to HAL 9000 and the Mac, the simple talks about upgrading a Navi - absent in any other show. Hard to find anime much less art willing to delve into the cold calculated cosmos of computing. Did it have to be a computer? No, it could be an experience; some object or some vision. But the integration of computers into the plot lends a timelessness, which only makes the messages of the show more important in the era of social media.
[west_virginia_pine]

2) "Present Day, Present Time" does Lain successfully manage to stay relevant to this day?

The series' timeless qualities with humanity at its core keep it relevant
It’s not so much that the series managed to be incredibly prescient in its speculative fiction elements, since much of what it asserts will transpire with the proliferation of the internet as displayed in the series was already underway at the time, rather it’s in the careful handling of the series’ evergreen themes that it attains this quality of relevance. One of the most interesting things Lain discusses is information; if a being had access to and control of all the information possessed by humanity collectively, would that person be distinguishable from God? Everything humans do is a result of electric impulses in the nervous system. We are as governed by the flow of information as they are. The show is timeless because of the human messages at its core - finding a sense of self and reaching out to people - more relevant as we lose ourselves in the mire of mass media. The show has a reputation for its cold existentialism but there's warm positive love at its heart.
[Pixelsaber krasnovian west_virgnia_pine]
Our increasingly digital lives make Lain more relevant then ever
The quote was really striking every episode, it was a constant reminder that stuck with us for the most part. Despite some clear technical and aesthetic elements, Lain feels like it could be just as easily be set today. One thing that stuck out to me was how easily one could understand how the whole space with The Wired worked when applying our understanding of the internet today. Our lives are connected via the internet more now than ever, especially with the current global pandemic, which makes the messages in the show resonate strongly with our present day and present time. Lain’s central theme is about the relationship between ourselves and our digital lives. It seems clear that what we do online is very much a part of us, or at the very least is never gone and can be dredged out of the depths of the internet to haunt us years later when we wish it didn’t exist. This happens daily and ranges from simple stuff like finding some old pictures on facebook to having things someone said years ago surface and ruin their careers. Present Day, Present Time is a little cheesy, but it really does capture the spirit of what is going on.
[ValkyrieCain9 isrozzis max_turner]
A focus on advanced 90's technology dates the show
The focus on contemporary technology really dates the show pretty hard in a way that more fantastical tech shows like mecha or futuristic anime aren't affected by. A giant robot or cyborg doesn't feel particularly old as they never really existed but seeing stacked CRTs, giant keyboard cell phones, classic Apple gear, and Lain's server room gives me a constant reminder that this stuff is quite old. The daily reminder explicitly calling out "Present day, Present Time" was necessary to tell me that this was supposed to feel cutting edge and really advanced. One wonders if the creators knew this and partly included the callout to counteract the chosen aesthetic that had no way of aging gracefully.
[RX-Nota-II]

3) What do you think of the role mental illness plays in this show?

A superb groundwork that is too quickly left behind
The series’ use of mental illnesses, or the appropriate equivalents for an entity of The Wired, is quite integral to the development of its mounting intrigue and is the reason the series is able to mete out it’s narrative in a suitably measured manner. It is also a suitably human element that helps the viewer more keenly sympathize with Lain, something which would have been difficult if a different stand-in element had been utilized instead. It is well done showing struggles with the disorder that feel surprisingly real, yet they dismiss it pretty suddenly as the show's brisk pacing focuses more on the superhuman. This is a shame since the groundwork laid to make a more interesting storyline based on the trauma is already there and it is not taken for the sake of either limited episode counts or a preferred pacing to get to the supernatural.
[Pixelsaber RX-Nota-II]
An accurate reflection of real illness that sets up the philosophical questions raised in the later half
I have a close family member who lives with schizophrenia, including auditory hallucinations. It’s made me consider the line between perception and reality in the same way Lain does. Lain addresses some of principles of solipsism but in the end rejects it as a valid model for viewing the world; perceiving something doesn’t mean that it’s real and not perceiving things does not eliminate its existence. From my admittedly secondhand understanding of my family member’s condition, Lain’s experience with The Wired captures certain elements of the experience quite accurately.
[krasnovian]
Not the most important aspect
The show doesn’t comment much on mental illness. The focus of the show is almost entirely on technology, how we interact with it, and what our relationship with our digital lives is. While there are depictions of mental health struggles in the show it doesn’t appear that the show is intentionally commenting on them. What is in the show is used to support our relationship with technology or is simply a plot device. It would be best to say that rather than Lain being depressed, it’s Lain grappling with the duality of her existence and the fact that maybe she’s not even human to begin with. There’s a lot to take in there.
[isrozzis]

4) What do you make of Lain’s path towards self-realization and how it is interlaced with her relationship with divinity?

Lain's humanity in the face of new development leads her to rediscover her divinity
Lain’s process of rediscovery and self-realization is notably punctuated, occuring in relation to revelations pertaining to the ongoing narrative, which Lain always reacts to in reasonable ways as a character, pushing her away from her fabricated existence and back into the role she had seemingly once occupied. It’s the interplay between Lain’s ‘known’ and unknown facets that is most interesting, as it is through her humanity that she often comes to not only learn more of herself in spite of her true nature. It’s the fact these understandably human actions and moments lead to Lain further isolating herself, putting herself in a position to be further exposed to her own divinity and the elements of The Wired, which indicates the necessity of both her humanity and inaction in her role as a godly entity of The Wired, posing interesting considerations as to the series’ concept of transhumanism.
[Pixelsaber]
A wild thriller that slowly converges to reveal the truth
This really is the bread and butter of Lain. The intersection of self realization and divinity creates a great opportunity for the thriller and mystery aspects of the show as all the revelations make sense yet seem totally unpredictable. The use of dissociative personalities here to create confusion and a gradual path towards reality was great. It plays perfectly with the wildly different ideas of divinity that arise from the kids gesturing to the sky to phantoms in the club to Eiri Masami as quite a standard looking anime villain. Further developing the answer towards the question of Lain's identity gets matched perfectly with a clearer idea of what a divine being truly is and the two paths eventually merge into a single universal answer: she is just a being that is omnipresent.
[RX-Nota-II]

5) The writer commented saying Alice in Lain is very similar to the Alice from Lewis Carol’s Alice in Wonderland. Do you agree or disagree with that statement?

Enough is there for an uninformed viewer to justify a similarity
With only some cursory familiarity to the story of Alice in Wonderland, some passing resemblance between the two characters can be still observed. Both Alices end up descending into a world that is unknown but somewhat familiar in pursuit of someone else. Book Alice’s traipse through Wonderland ends up being naught but a dream, and although us the viewers know that the events which transpired in the series where as real as can be managed, Alice’s knowledge of the events and of Lain’s existence post-reset is not unlike the faded traces of a forgotten dream.
[Pixelsaber]
it is the titular characters of both works which makes for a proper comparison
Alice in Wonderland’s basic plot can be found in many other stories and Lain does not seem to be an exception to this. The story of a girl who finds herself in a new and fascinating world and by taking a journey through it comes to learn about the world and herself, is something seen clearly in Lain. Though we would argue that this story line fits more with Lain than with Alice. For one, Lain’s room becomes a sort of physical manifestation of the “wonderland” of The Wired as she gets sucked further into it. There are also several close ties to see in each of the plots. There is some sort of call to this world. For Alice it was the white rabbit in a waistcoat and for Lain it was the messages she received from Chisa. Alice finds herself in different precarious situations being caused as well as aided by “eat me” and “drink me” biscuits and potions in order to alter her physical form, while Lain enters The Wired by abandoning her physical form altogether, both of which leave the girls with very little sense of self. And the question of ‘Who am I?’ is not just something that nags at them but can also be seen in their interactions with other people, some who are just as curious as they are like the giant caterpillar smoking a hookah, while claiming to know who they are, like the kids at Cyberia. Alice in Wonderland’s plot is very basic at its core and so it transfers really well to other stories while still allowing the stories to be just as unique like with Lain, but also comparing Lain to Alice in Wonderland helps to ground it in something a lot more familiar for some.
[ValkyrieCain9]

6) What is your interpretation of the rock/jazz free form section of the first half of episode 11?

The recap emphasizes the authentic feelings evoked by memories even if they are lies
The segment begins with a frame of text: "Memory isn't something so vague" then dives straight into a quite a straightforward recap. This is clearly a rejection or an attempt to reject Eiri's assertion that Lain's memories are a lie. Lain wants to prove that her memories aren't vague, they are real, and that her relationships are also real. Interestingly the word used for vague here is 曖昧 which has a letter quite similar to the Japanese for love 愛. The recap blitz then ends on a text screen showing 'aliceLOVE needs you' along with some nonsense Japanese text saying something poetic about a loving heart. The bookends clearly want to emphasize the love Lain sees even though there are plenty of memories flashed in that have nothing to do with that side of the show. The moments she had with Alice were real, the feelings she had towards Alice were real, and the connection she shared with Alice and everyone else she encountered was undoubtedly real.
[RX-Nota-II max_turner]
Undoubtedly Iconic. Frustratingly mysterious
At surface level the nearly eleven minute free form rock/jazz odyssey is a recap of events that have happened over the show that is explained away as Lain installing an emulator of Navi into herself and that resulting in information overload, but it strikes me odd that Lain would do that without a reason so perhaps that’s not the sole reason. The choice of music stands out to me in particular, as the show is heavily rooted in the denpa aesthetic which does not really lend itself to jazz and rock. Jazz is very free flowing with few rules and restrictions which is possibly used to show the free flow of information into Lain at this moment. Ultimately it is difficult to really pin down why this section exists, and yet it’s always seen as an iconic part of the show.
[isrozzis]
Remember that any information not found early in the show itself is considered a spoiler. Please properly tag spoilers!
Or else...

Next week's anime discussion thread: Death;Note

Further information about past and upcoming discussions can be found on the Weekly Discussion wiki page.
Check out anime Writing Club's wiki page Please PM u/DrJWilson for any concerns or interest in joining the club!
submitted by RX-Nota-II to nota [link] [comments]


2020.09.13 23:00 rogor_ Testing markdown

Note: For a full list of markdown syntax, see the official syntax guide. Also note that reddit doesn't support images, for which I am grateful, as that would most definitely be the catalyst needed to turn reddit into 4chan (/circlejerk/, which uses CSS trickery to permit some level of image posting, is a great example of the destructive power of images).

PARAGRAPHS

Paragraphs are delimited by a blank line. Simply starting text on a new line won't create a new paragraph; It will remain on the same line in the final, rendered version as the previous line. You need an extra, blank line to start a new paragraph. This is especially important when dealing with quotes and, to a lesser degree, lists.
You can also add non-paragraph line breaks by ending a line with two spaces. The difference is subtle:
Paragraph 1, Line 1 Paragraph 1, Line 2
Paragraph 2

FONT FORMATTING

Italics

Text can be displayed in an italic font by surrounding a word or words with either single asterisks (*) or single underscores (_).
For example:
This sentence includes *italic text*.
is displayed as:
This sentence includes italic text.

Bold

Text can be displayed in a bold font by surrounding a word or words with either double asterisks (*) or double underscores (_).
For example:
This sentence includes **bold text**.
is displayed as:
This sentence includes bold text.

Strikethrough

Text can be displayed in a strikethrough font by surrounding a word or words with double tildes (~~). For example:
This sentence includes ~ ~strikethrough text~ ~
(but with no spaces between the tildes; escape sequences [see far below] appear not to work with tildes, so I can't demonstrate the exact usage).
is displayed as:
This sentence includes strikethrough text.

Superscript

Text can be displayed in a superscript font by preceding it with a caret ( ^ ).
This sentence includes super^ script
(but with no spaces after the caret; Like strikethrough, the superscript syntax doesn't play nicely with escape sequences).
is displayed as:
This sentence includes superscript.
Superscripts can even be nested: justlikethis .
However, note that the superscript font will be reset by a space. To get around this, you can enclose the text in the superscript with parentheses. The parentheses won't be displayed in the comment, and everything inside of them will be superscripted, regardless of spaces:
This sentence^ (has a superscript with multiple words)
Once again, with no space after the caret.
is displayed as
This sentencehas a superscript with multiple words

Headers

Markdown supports 6 levels of headers (some of which don't actually display as headers in reddit):

Header 1

Header 2

Header 3

Header 4

Header 5
Header 6
...which can be created in a couple of different ways. Level 1 and 2 headers can be created by adding a line of equals signs (=) or dashes (-), respectively, underneath the header text.
However, all types of headers can be created with a second method. Simply prepend a number of hashes (#) corresponding to the header level you want, so:
# Header 1
## Header 2
### Header 3
#### Header 4
##### Header 5
###### Header 6
results in:

Header 1

Header 2

Header 3

Header 4

Header 5
Header 6
Note: you can add hashes after the header text to balance out how the source code looks without affecting what is displayed. So:
## Header 2 ##
also produces:

Header 2

LISTS

Markdown supports two types of lists: ordered and unordered.

Unordered Lists

Prepend each element in the list with either a plus (+), dash (-), or asterisk (*) plus a space. Line openers can be mixed. So
* Item 1
+ Item 2
- Item 3
results in
  • Item 1
  • Item 2
  • Item 3

Ordered Lists

Ordered lists work roughly the same way, but you prepend each item in the list with a number plus a period (.) plus a space. Also, it makes no difference what numbers you use. The ordered list will always start with the number 1, and will always increment sequentially. So
7. Item 1
2. Item 2
5. Item 3
results in
  1. Item 1
  2. Item 2
  3. Item 3
Also, you can nest lists, like so:
  1. Ordered list item 1
    • Bullet 1 in list item 2
    • Bullet 2 in list item 2
  2. List item 3
Note: If your list items consist of multiple paragraphs, you can force each new paragraph to remain in the previous list item by indenting it by one tab or four spaces. So
* This item has multiple paragraphs.
(four spaces here)This is the second paragraph
* Item 2
results in:
  • This item has multiple paragraphs.
    This is the second paragraph
  • Item 2
Notice how the spaces in my source were stripped out? What if you need to preserve formatting? That brings us to:

CODE BLOCKS AND INLINE CODE

Inline code is easy. Simply surround any text with backticks (`), not to be confused with apostrophes ('). Anything between the backticks will be rendered in a fixed-width font, and none of the formatting syntax we're exploring will be applied. So
Here is some `inline code with **formatting**`
is displayed as:
Here is some inline code with **formatting**
Note that this is why you should use the normal apostrophe when typing out possessive nouns or contractions. Otherwise you may end up with something like:
I couldnt believe that he didnt know that!
Sometimes you need to preserve indentation, too. In those cases, you can create a block code element by starting every line of your code with four spaces (followed by other spaces that will be preserved). You can get results like the following:
public void main(Strings argv[]){ System.out.println("Hello world!"); } 

LINKS

There are a couple of ways to get HTML links. The easiest is to just paste a valid URL, which will be automatically parsed as a link. Like so:
http://en.wikipedia.org
However, usually you'll want to have text that functions as a link. In that case, include the text inside of square brackets followed by the URL in parentheses. So:
[Wikipedia](http://en.wikipedia.org).
results in:
Wikipedia.
You can also provide tooltip text for links like so:
[Wikipedia](http://en.wikipedia.org "tooltip text").
results in:
Wikipedia.
There are other methods of generating links that aren't appropriate for discussion-board style comments. See the Markdown Syntax if you're interested in more info.

BLOCK QUOTES

You'll probably do a lot of quoting of other redditors. In those cases, you'll want to use block quotes. Simple begin each line you want quoted with a right angle bracket (>). Multiple angle brackets can be used for nested quotes. To cause a new paragraph to be quoted, begin that paragraph with another angle bracket. So the following:
>Here's a quote. >Another paragraph in the same quote. >>A nested quote. >Back to a single quote. And finally some unquoted text. 
Is displayed as:
Here's a quote.
Another paragraph in the same quote.
A nested quote.
Back to a single quote.
And finally some unquoted text.

MISCELLANEOUS

Tables

Reddit has the ability to represent tabular data in fancy-looking tables. For example:
some header labels
Left-justified center-justified right-justified
a b c
d e f
Which is produced with the following markdown:
someheaderlabels :---:--:---: Left-justifiedcenter-justifiedright-justified abc def
All you need to produce a table is a row of headers separated by "pipes" (), a row indicating how to justify the columns, and 1 or more rows of data (again, pipe-separated).
The only real "magic" is in the row between the headers and the data. It should ideally be formed with rows dashes separated by pipes. If you add a colon to the left of the dashes for a column, that column will be left-justified. To the right for right justification, and on both sides for centered data. If there's no colon, it defaults to left-justified.
Any number of dashes will do, even just one. You can use none at all if you want it to default to left-justified, but it's just easier to see what you're doing if you put a few in there.
Also note that the pipes (signifying the dividing line between cells) don't have to line up. You just need the same number of them in every row.

Escaping special characters

If you need to display any of the special characters, you can escape that character with a backslash (\). For example:
Escaped \*italics\*
results in:
Escaped *italics*

Horizontal rules

Finally, to create a horizontal rule, create a separate paragraph with 5 or more asterisks (*).
*****
results in
submitted by rogor_ to rogorztest [link] [comments]


2020.09.13 05:41 snakecloth This is a test.

Note: For a full list of markdown syntax, see the official syntax guide. Also note that reddit doesn't support images, for which I am grateful, as that would most definitely be the catalyst needed to turn reddit into 4chan (/circlejerk/, which uses CSS trickery to permit some level of image posting, is a great example of the destructive power of images).

PARAGRAPHS

Paragraphs are delimited by a blank line. Simply starting text on a new line won't create a new paragraph; It will remain on the same line in the final, rendered version as the previous line. You need an extra, blank line to start a new paragraph. This is especially important when dealing with quotes and, to a lesser degree, lists.
You can also add non-paragraph line breaks by ending a line with two spaces. The difference is subtle:
Paragraph 1, Line 1 Paragraph 1, Line 2
Paragraph 2

FONT FORMATTING

Italics

Text can be displayed in an italic font by surrounding a word or words with either single asterisks (*) or single underscores (_).
For example:
This sentence includes *italic text*.
is displayed as:
This sentence includes italic text.

Bold

Text can be displayed in a bold font by surrounding a word or words with either double asterisks (*) or double underscores (_).
For example:
This sentence includes **bold text**.
is displayed as:
This sentence includes bold text.

Strikethrough

Text can be displayed in a strikethrough font by surrounding a word or words with double tildes (~~). For example:
This sentence includes ~ ~strikethrough text~ ~
(but with no spaces between the tildes; escape sequences [see far below] appear not to work with tildes, so I can't demonstrate the exact usage).
is displayed as:
This sentence includes strikethrough text.

Superscript

Text can be displayed in a superscript font by preceding it with a caret ( ^ ).
This sentence includes super^ script
(but with no spaces after the caret; Like strikethrough, the superscript syntax doesn't play nicely with escape sequences).
is displayed as:
This sentence includes superscript.
Superscripts can even be nested: justlikethis .
However, note that the superscript font will be reset by a space. To get around this, you can enclose the text in the superscript with parentheses. The parentheses won't be displayed in the comment, and everything inside of them will be superscripted, regardless of spaces:
This sentence^ (has a superscript with multiple words)
Once again, with no space after the caret.
is displayed as
This sentencehas a superscript with multiple words

Headers

Markdown supports 6 levels of headers (some of which don't actually display as headers in reddit):

Header 1

Header 2

Header 3

Header 4

Header 5
Header 6
...which can be created in a couple of different ways. Level 1 and 2 headers can be created by adding a line of equals signs (=) or dashes (-), respectively, underneath the header text.
However, all types of headers can be created with a second method. Simply prepend a number of hashes (#) corresponding to the header level you want, so:
# Header 1
## Header 2
### Header 3
#### Header 4
##### Header 5
###### Header 6
results in:

Header 1

Header 2

Header 3

Header 4

Header 5
Header 6
Note: you can add hashes after the header text to balance out how the source code looks without affecting what is displayed. So:
## Header 2 ##
also produces:

Header 2

LISTS

Markdown supports two types of lists: ordered and unordered.

Unordered Lists

Prepend each element in the list with either a plus (+), dash (-), or asterisk (*) plus a space. Line openers can be mixed. So
* Item 1
+ Item 2
- Item 3
results in
  • Item 1
  • Item 2
  • Item 3

Ordered Lists

Ordered lists work roughly the same way, but you prepend each item in the list with a number plus a period (.) plus a space. Also, it makes no difference what numbers you use. The ordered list will always start with the number 1, and will always increment sequentially. So
7. Item 1
2. Item 2
5. Item 3
results in
  1. Item 1
  2. Item 2
  3. Item 3
Also, you can nest lists, like so:
  1. Ordered list item 1
    • Bullet 1 in list item 2
    • Bullet 2 in list item 2
  2. List item 3
Note: If your list items consist of multiple paragraphs, you can force each new paragraph to remain in the previous list item by indenting it by one tab or four spaces. So
* This item has multiple paragraphs.
(four spaces here)This is the second paragraph
* Item 2
results in:
  • This item has multiple paragraphs.
    This is the second paragraph
  • Item 2
Notice how the spaces in my source were stripped out? What if you need to preserve formatting? That brings us to:

CODE BLOCKS AND INLINE CODE

Inline code is easy. Simply surround any text with backticks (`), not to be confused with apostrophes ('). Anything between the backticks will be rendered in a fixed-width font, and none of the formatting syntax we're exploring will be applied. So
Here is some `inline code with **formatting**`
is displayed as:
Here is some inline code with **formatting**
Note that this is why you should use the normal apostrophe when typing out possessive nouns or contractions. Otherwise you may end up with something like:
I couldnt believe that he didnt know that!
Sometimes you need to preserve indentation, too. In those cases, you can create a block code element by starting every line of your code with four spaces (followed by other spaces that will be preserved). You can get results like the following:
public void main(Strings argv[]){ System.out.println("Hello world!"); } 

LINKS

There are a couple of ways to get HTML links. The easiest is to just paste a valid URL, which will be automatically parsed as a link. Like so:
http://en.wikipedia.org
However, usually you'll want to have text that functions as a link. In that case, include the text inside of square brackets followed by the URL in parentheses. So:
[Wikipedia](http://en.wikipedia.org).
results in:
Wikipedia.
You can also provide tooltip text for links like so:
[Wikipedia](http://en.wikipedia.org "tooltip text").
results in:
Wikipedia.
There are other methods of generating links that aren't appropriate for discussion-board style comments. See the Markdown Syntax if you're interested in more info.

BLOCK QUOTES

You'll probably do a lot of quoting of other redditors. In those cases, you'll want to use block quotes. Simple begin each line you want quoted with a right angle bracket (>). Multiple angle brackets can be used for nested quotes. To cause a new paragraph to be quoted, begin that paragraph with another angle bracket. So the following:
>Here's a quote. >Another paragraph in the same quote. >>A nested quote. >Back to a single quote. And finally some unquoted text. 
Is displayed as:
Here's a quote.
Another paragraph in the same quote.
A nested quote.
Back to a single quote.
And finally some unquoted text.

MISCELLANEOUS

Tables

Reddit has the ability to represent tabular data in fancy-looking tables. For example:
some header labels
Left-justified center-justified right-justified
a b c
d e f
Which is produced with the following markdown:
someheaderlabels :---:--:---: Left-justifiedcenter-justifiedright-justified abc def
All you need to produce a table is a row of headers separated by "pipes" (), a row indicating how to justify the columns, and 1 or more rows of data (again, pipe-separated).
The only real "magic" is in the row between the headers and the data. It should ideally be formed with rows dashes separated by pipes. If you add a colon to the left of the dashes for a column, that column will be left-justified. To the right for right justification, and on both sides for centered data. If there's no colon, it defaults to left-justified.
Any number of dashes will do, even just one. You can use none at all if you want it to default to left-justified, but it's just easier to see what you're doing if you put a few in there.
Also note that the pipes (signifying the dividing line between cells) don't have to line up. You just need the same number of them in every row.

Escaping special characters

If you need to display any of the special characters, you can escape that character with a backslash (\). For example:
Escaped \*italics\*
results in:
Escaped *italics*

Horizontal rules

Finally, to create a horizontal rule, create a separate paragraph with 5 or more asterisks (*).
*****
results in
submitted by snakecloth to test [link] [comments]


2020.09.09 03:53 gabigooo iDrac R720 help

Hey guys,
I tried to upgrade my iDrac via the web console and now it is not working anymore, and I can't load the Life Cycle Management to try to fix it. I followed the instruction from here ( https://www.reddit.com/homelab/comments/a49b4y/r720_idrac_help/ ) and I am logging in via j_idrac_uart.
It looks like my mmc partition table is broken and I can not mount the partitions anymore. I tried to use fdisk -l to show the partitions but the mmc ones are not showing I can only see /dev/mtdblock0.
That said this is my boot log from the uart connection.
I am kinda stuck here so any suggestions are highly appreciated
U-Boot 2009.08 (Nov 04 2012 - 19:53:53) Avocent (0.0.3) EVB, Build: jenkins-idrac-yocto-release-88 CPU: SH-4A BOARD: R0P7757LC00xxRL (C0 step) board BOOT: Secure, HRK generated DRAM: 240MB (240MB of 256MB total DRAM is available on U-Boot) ENV: Using primary env area. In: serial Out: serial Err: serial PCIe: Bridge loaded with 0x18000 bytes WDT2: Booted Lower Vector, 'uboot1' sh_mmcif: 0, sh-sdhi: 1 Net: sh_eth.0, sh_g_eth.0 INFO: 00:002 Start-up -to- util_idrac_main() INFO: 00:004 U-Boot 2009.08 (Nov 04 2012 - 19:53:53) Avocent (0.0.3) EVB INFO: 00:007 U-Boot checkin date(07-30-2012) Version(1.0.179) INFO: 00:006 iDRAC PPID  INFO: 00:003 SPI NOR init 4096 KiB N25Q032 bus=0 cs=0, speed=1000000, mode=3 INFO: 00:007 SH-4A Product: Major Ver=0x31 Minor Ver=0x13 C3 Little endian Family=0x10 Major Ver=0x30 Minor Ver=0x0b PASS: 00:016 Dedicated monolithic mgmt NIC disabled INFO: 00:128 BCM54610 OUI=0x3fffff Model=0x3f Revision=0x0f PhyAddr=1 INFO: 00:007 SD CARD: is not found INFO: 00:448 EMMC: Device: sh_mmcif Manufacturer ID: 90 OEM: 14a Name: HYNIX Tran Speed: 25000000 Rd Block Len: 512 MMC version 4.0 High Capacity: Yes Capacity: 0 INFO: 00:019 CPLD: Major Ver=0x1 Minor Ver=0x0 Maint Ver=0x3 Planar: Type=0x02 Rev=0x8 Rework=0x0 Scratch/PathRetry=0x00 PASS: 00:014 Coin cell detected good, AD=0x389 low water=0x2c1 PASS: 00:007 PCIe C0 Ver=0.13 MCTP en, CRC=0x19592849 @0x8efbf4fc cnt=0x18000 INFO: 00:008 Init PCIe mailbox(PCIe 0xFFEE0150=0x40010000) INFO: 00:005 mode=normal INFO: 00:003 reset_cause=ac PASS: 00:004 Booted Lower Vector, 'uboot1' wdt2cnt=4 INFO: 00:005 wdt0cnt=6 PASS: 00:003 Clear CH1/CH2, clear 4K shared [email protected] on AC power up PASS: 00:007 SMR0 no sermux env, default 0xd4 INFO: 00:004 GRACR=0x3c HISEL=0x00 SIRQCR5_D=0x03 SIRQCR6_D=0x01 LADMSK0=0xff2 MRSTCR0=0xfedffe7f MRSTCR1=0xfff3ff0f MRSTCR2=0x7f80feff BARMAP=0x1 BCR=0x85000000 NCER=0x01fc NCMCR=0x0006 NCCSR=0x0303 PASS: 00:022 etherc0=78:45:C4:F5:9C:38 getherc0=78:45:C4:F5:9C:39 INFO: 00:009 Fan logic for monolithic planar type 2 fan1 - def 0000 1fff 3d fan2 - def 0000 1fff 3d fan3 - def 0000 1fff 3d fan4 - def 0000 1fff 3d fan5 - def 0000 1fff 3d fan6 - def 0000 1fff 3d fan7 - def 0000 1fff 3d fan8 - def 0000 1fff 3d INFO: 00:076 Env and backup CRC'ed ok *** no text signature found *** INFO: 00:533 Sync eMMC/SPI NOAlternate u-boot images PASS: 00:258 Current u-boot1 1.0.179 verified with 'ubootN' Trailer Struct - Missing start token, exp=0xc0de1111 rec=0x0 U-boot2 in sync with u-boot1 1.0.179 PASS: 03:654 Verify OS Images N: CRC32 OK: Kernel=0x9e279bb3 Rootfs=0xb061ff1 PASS: 00:007 Boot device=emmc Boot partition1/N Boot Path Retry:P1/N=0 P5/N-1=0 INFO: 00:000 05:275 WDT2: Disabled Initialization complete, proceed with boot OS_WDT0_EN:180 seconds, Re-load ILRAM: Boot Path Retry:P1/N=0 P5/N-1=0 Copying kernel image ... OK ## Booting kernel from Legacy Image at 88000000 ... Image Name: sh-linux Image Type: SuperH Linux Kernel Image (gzip compressed) Data Size: 2537538 Bytes = 2.4 MB Load Address: 80001000 Entry Point: 80002000 Verifying Checksum ... OK Uncompressing Kernel Image ... OK WDT2: Disable in do_bootm_linux() sh_eth_init Monolithic/DRB init started: BusyBox v1.18.4 (2012-11-04 19:32:12 CST) starting pid 407, tty '': '/etc/init.d/rcS' waitfor: pid 407 ... setting net.ipv6.conf.default.accept_dad based on kernel bootup option enable normal accept DAD for ipv6 Sat Jan 1 00:00:01 UTC 2000 To execute command __source /etc/sysapps_script/I_1000_mountfs.sh__ Sat Jan 1 00:00:02 UTC 2000 To execute command __source /etc/sysapps_script/I_1001_trigwdt.sh__ <========= Start H/W watchdog first... =========> Sat Jan 1 00:00:02 UTC 2000 To execute command __source /etc/sysapps_script/I_1100_nfs.sh__ Sat Jan 1 00:00:02 UTC 2000 To execute command __source /etc/sysapps_script/I_1105_ps.sh__ XXXXXX /dev/mmcblk0p11 /dev/mmcblk0p11: recovering journal fsck.ext3: Attempt to read block from filesystem resulted in short read while trying to re-open /dev/mmcblk0p11 e2fsck: io manager magic bad! e2fsck 1.41.14 (22-Dec-2010) fsck.ext3: Attempt to read block from filesystem resulted in short read while trying to open /dev/mmcblk0p11 Could this be a zero-length partition? mount: mounting /dev/mmcblk0p11 on /flash/data0 failed: Invalid argument mounting private storage fail, formatting partition mke2fs 1.41.14 (22-Dec-2010) Warning: could not erase sector 2: Attempt to write block from filesystem resulted in short write Filesystem label= OS type: Linux Block size=1024 (log=0) Fragment size=1024 (log=0) Stride=0 blocks, Stripe width=0 blocks 1024 inodes, 4096 blocks 204 blocks (4.98%) reserved for the super user First data block=1 Maximum filesystem blocks=4194304 1 block group 8192 blocks per group, 8192 fragments per group 1024 inodes per group Warning: could not read block 0: Attempt to read block from filesystem resulted in short read Warning: could not erase sector 0: Attempt to write block from filesystem resulted in short write Writing inode tables: 0/1 Could not write 8 blocks in inode table starting at 24: Attempt to write block from filesystem resulted in short write tune2fs 1.41.14 (22-Dec-2010) tune2fs: Attempt to read block from filesystem resulted in short read while trying to open /dev/mmcblk0p11 Couldn't find valid filesystem superblock. mount: mounting /dev/mmcblk0p11 on /flash/data0 failed: Invalid argument Sat Jan 1 00:00:03 UTC 2000 To execute command __source /etc/sysapps_script/I_1106_clear_ps.sh__ mkdir: can't create directory '/flash/data0/oem_ps': Read-only file system Sat Jan 1 00:00:03 UTC 2000 To execute command __source /etc/sysapps_script/I_1150_SYS_Drv.sh__ insmod: read error from '/lib/modules/aess_eventhandlerdrv.ko': Input/output error insmod: can't insert '/lib/modules/aess_eventhandlerdrv.ko': Input/output error insmod: read error from '/lib/modules/aess_kcsdrv.ko': Input/output error insmod: can't insert '/lib/modules/aess_kcsdrv.ko': Input/output error insmod: read error from '/lib/modules/aess_biospostdrv.ko': Input/output error insmod: can't insert '/lib/modules/aess_biospostdrv.ko': Input/output error insmod: read error from '/lib/modules/aess_gpiodrv.ko': Input/output error insmod: can't insert '/lib/modules/aess_gpiodrv.ko': Input/output error insmod: read error from '/lib/modules/aess_sgpiodrv.ko': Input/output error insmod: can't insert '/lib/modules/aess_sgpiodrv.ko': Input/output error insmod: read error from '/lib/modules/aess_dynairqdrv.ko': Input/output error insmod: can't insert '/lib/modules/aess_dynairqdrv.ko': Input/output error insmod: read error from '/lib/modules/aess_i2c_hwctrldrv.ko': Input/output error insmod: can't insert '/lib/modules/aess_i2c_hwctrldrv.ko': Input/output error insmod: read error from '/lib/modules/aess_i2cdrv.ko': Input/output error insmod: can't insert '/lib/modules/aess_i2cdrv.ko': Input/output error insmod: read error from '/lib/modules/aess_pecisensordrv.ko': Input/output error insmod: can't insert '/lib/modules/aess_pecisensordrv.ko': Input/output error insmod: read error from '/lib/modules/cryptodev.ko': Input/output error insmod: can't insert '/lib/modules/cryptodev.ko': Input/output error insmod: read error from '/lib/modules/sh_tsip.ko': Input/output error insmod: can't insert '/lib/modules/sh_tsip.ko': Input/output error insmod: read error from '/lib/modules/aess_fansensordrv.ko': Input/output error insmod: can't insert '/lib/modules/aess_fansensordrv.ko': Input/output error insmod: read error from '/lib/modules/aess_pwmdrv.ko': Input/output error insmod: can't insert '/lib/modules/aess_pwmdrv.ko': Input/output error insmod: read error from '/lib/modules/aess_timerdrv.ko': Input/output error insmod: can't insert '/lib/modules/aess_timerdrv.ko': Input/output error insmod: read error from '/lib/modules/aess_adcsensordrv.ko': Input/output error insmod: can't insert '/lib/modules/aess_adcsensordrv.ko': Input/output error insmod: read error from '/lib/modules/VKCSDriver.ko': Input/output error insmod: can't insert '/lib/modules/VKCSDriver.ko': Input/output error insmod: read error from '/lib/modules/aess_memdrv.ko': Input/output error insmod: can't insert '/lib/modules/aess_memdrv.ko': Input/output error Sat Jan 1 00:00:05 UTC 2000 To execute command __source /etc/sysapps_script/I_1151_SYS_Drv.sh__ insmod: read error from '/lib/modules/aess_spi1drv.ko': Input/output error insmod: can't insert '/lib/modules/aess_spi1drv.ko': Input/output error insmod: read error from '/lib/modules/dell_cplddrv.ko': Input/output error insmod: can't insert '/lib/modules/dell_cplddrv.ko': Input/output error insmod: read error from '/lib/modules/aess_rspidrv.ko': Input/output error insmod: can't insert '/lib/modules/aess_rspidrv.ko': Input/output error insmod: read error from '/lib/modules/dell_fpdrv.ko': Input/output error insmod: can't insert '/lib/modules/dell_fpdrv.ko': Input/output error insmod: read error from '/lib/modules/sh_pbi.ko': Input/output error insmod: can't insert '/lib/modules/sh_pbi.ko': Input/output error Sat Jan 1 00:00:05 UTC 2000 To execute command __source /etc/sysapps_script/I_1170_mknode.sh__ Sat Jan 1 00:00:06 UTC 2000 To execute command __/etc/sysapps_script/config_lib_init.sh__ mounting Platform Data 1 partition mount: mounting /dev/mmcblk0p9 on /tmp/pd0/ failed: Input/output error /etc/sysapps_script/config_lib_init.sh: line 28: /etc/default/ipmi/getsysid: not found mkdir: can't create directory '/flash/data0/config/': Read-only file system /etc/sysapps_script/config_lib_init.sh: cd: line 38: can't cd to /flash/data0/config/ ln: ./lmcfg.txt: Read-only file system ln: ./platcfggrp.txt: Read-only file system ln: ./platcfgfld.txt: Read-only file system ln: ./cfgfld.txt: Read-only file system ln: ./cfggrp.txt: Read-only file system ln: ./gencfggrp.txt: Read-only file system ln: ./gencfgfld.txt: Read-only file system ln: ./nonpmaltdefaults.txt: Read-only file system ln: ./altdefaults.txt: Read-only file system MemAccess: error while loading shared libraries: /uslib/libmemaccess.so.1: cannot read file data: Input/output error cp: can't stat '/tmp/pd0/network_config/Orca/iDRACnet.default': No such file or directory cp: can't stat '/tmp/pd0/network_config/Orca/NICSelection.sh': No such file or directory Sat Jan 1 00:00:06 UTC 2000 To execute command __source /etc/sysapps_script/I_1160_OSINET.sh__ Sat Jan 1 00:00:06 UTC 2000 To execute command __source /etc/sysapps_script/I_1200_etc_defaults.sh__ cp: can't create '/flash/data0/etc/hosts': Read-only file system mkdir: can't create directory '/flash/data0/sysconfig': Read-only file system /etc/sysapps_script/network_dev_init.sh: line 34: /tmp/pd0/ipmi/getsysid: not found mkdir: can't create directory '/flash/data0/ipsec': Read-only file system cp: can't create '/flash/data0/etc/hosts': Read-only file system Sat Jan 1 00:00:06 UTC 2000 To execute command __source /etc/sysapps_script/I_1210_sysklog_syslogd.sh__ /etc/init.d/rcS: /etc/sysapps_script/I_1210_sysklog_syslogd.sh: line 16: /etc/sysapps_script/syslog.sh: Input/output error Sat Jan 1 00:00:07 UTC 2000 To execute command __source /etc/sysapps_script/I_trab_asdf.sh__ insmod: read error from '/lib/modules/trab.ko': Input/output error insmod: can't insert '/lib/modules/trab.ko': Input/output error Sat Jan 1 00:00:07 UTC 2000 To execute command __source /etc/sysapps_script/I_usb_drv.sh__ NOTICE: Not full features configuration - kbdmouse not operational insmod: read error from '/lib/modules/g_r8a66597_udc.ko': Input/output error insmod: can't insert '/lib/modules/g_r8a66597_udc.ko': Input/output error failed load of g_r8a66597_udc Sat Jan 1 00:00:07 UTC 2000 To execute command __source /etc/sysapps_script/I_video_drv.sh__ insmod: read error from '/lib/modules/aess_video.ko': Input/output error insmod: can't insert '/lib/modules/aess_video.ko': Input/output error waitfor: pid 407, wpid 407 Please press Enter to activate this console. 
submitted by gabigooo to homelab [link] [comments]


2020.09.06 15:40 whipnil Medical Myths VII: Hypothesis, Theory, Law

From Merriam Webster-

The Difference Between Hypothesis and Theory

A hypothesis is an assumption, an idea that is proposed for the sake of argument so that it can be tested to see if it might be true.
In the scientific method, the hypothesis is constructed before any applicable research has been done, apart from a basic background review. You ask a question, read up on what has been studied before, and then form a hypothesis.
A hypothesis is usually tentative; it's an assumption or suggestion made strictly for the objective of being tested.
A theory, in contrast, is a principle that has been formed as an attempt to explain things that have already been substantiated by data. It is used in the names of a number of principles accepted in the scientific community, such as the Big Bang Theory. Because of the rigours of experimentation and control, it is understood to be more likely to be true than a hypothesis is.
In non-scientific use, however, hypothesis and theory are often used interchangeably to mean simply an idea, speculation, or hunch, with theory being the more common choice.
Since this casual use does away with the distinctions upheld by the scientific community, hypothesis and theory are prone to being wrongly interpreted even when they are encountered in scientific contexts—or at least, contexts that allude to scientific study without making the critical distinction that scientists employ when weighing hypotheses and theories.
The most common occurrence is when theory is interpreted—and sometimes even gleefully seized upon—to mean something having less truth value than other scientific principles. (The word law applies to principles so firmly established that they are almost never questioned, such as the law of gravity.)
This mistake is one of projection: since we use theory in general to mean something lightly speculated, then it's implied that scientists must be talking about the same level of uncertainty when they use theory to refer to their well-tested and reasoned principles.
The distinction has come to the forefront particularly on occasions when the content of science curricula in schools has been challenged—notably, when a school board in Georgia put stickers on textbooks stating that evolution was "a theory, not a fact, regarding the origin of living things." As Kenneth R. Miller, a cell biologist at Brown University, has said, a theory "doesn’t mean a hunch or a guess. A theory is a system of explanations that ties together a whole bunch of facts. It not only explains those facts, but predicts what you ought to find from other observations and experiments.”
While theories are never completely infallible, they form the basis of scientific reasoning because, as Miller said "to the best of our ability, we’ve tested them, and they’ve held up."
THE HIV/AIDS HYPOTHESIS
HIV-AIDS hypothesis out of touch with South African AIDS – A new perspective (pdf warning)
"A recent study by Chigwedere et al., ‘‘Estimating the lost benefits of antiretroviral drug use in South Africa”, claims that during the period from 2000 to 2005 about 330,000 South African AIDS-deaths were caused by the Human Immunodeficiency Virus (HIV) per year that could have been prevented by available anti-HIV drugs. The study blamed those who question the hypothesis that HIV is the cause of AIDS, particularly former South African President Thabo Mbeki and one of us, for not preventing these deaths by anti-HIV treatments"
"We conclude that the claims that HIV has caused huge losses of African lives are unconfirmed and that HIV is not sufficient or even necessary to cause the previously known diseases, now called AIDS in the presence of antibody against HIV. Further we call into question the claim that HIV antibody-positives would benefit from anti-HIV drugs, because these drugs are inevitably toxic and because there is as yet no proof that HIV causes AIDS."
Fallacies in Modern Medicine - The HIV/AIDS Hypothesis
In essence HIV has never been isolated and characterised. There are no clinical symptoms specific to AIDS. All AIDS related diseases can be caused by other factors with the pathologies noted in the gayUS community such as the Kaposi Sarcomas (KS) being explainable by oxidative stress and disruption to Nitrous Oxide pathways, while there is almost never KS in the African cohort and all the AIDS related pathologies there explainable by poor nutrition.
ALTERNATIVE HYPOTHESIS
Oxidative Stress, HIV and AIDS (pdf warning)
"It has been accepted by researchers at the CDC that KS (Kaposi's sarcoma), the first and most specific of the AIDS indicator diseases, for which the explanation of the HIV hypothesis was put forward by Gallo in 1982, is not caused directly or indirectly by HIV (Beral et al., 1990). On the other hand, recent empirical observations from three seemingly unrelated areas of AIDS research are in agreement with the hypothesis that oxidative mechanisms play a critical role in HIV expression and AIDS development.
"Thus, the systemic decrease of glutathione concentration in HIV seropositive individuals may result from both, decrease in synthesis and increased degradation. The oxidative stress to which the AIDS patients are subjected would lead to cellular anomalies in many cells, including lymphocytes, resulting in opportunistic infection, immunological abnormalities and neoplasia. All this argues in favour of oxidation as being a critical factor in the pathogenesis of AIDS and HIV expression."
This paper was published in 1993
The Silent Revolution in Cancer and AIDS Medicine
📷Michael McEvoy5.0 out of 5 stars Remarkable Work, Incredibly Important Book For Intensive ResearchersReviewed in the United States on November 22, 2018Verified PurchaseDr. Heinrich Kremer has written a masterful book that describes with intricate details the major problems with the HIV/AIDS research and theory. Kremer highlights the reality of functional TH2 imbalance within the immune cells as a counterregulatory shift set off by longterm oxidative stress. Mitochondrial dysfunction, coupled by thiol deficiency and redox disequilibrium leads to cachexia, immunological dysfunction in both AIDS and cancer. Toxic drugs perpetuate the problem of chronic thiol depletion and redox dysfunction. Must read for anyone wanting a deep dive into biochemistry, the historical context of AIDS, and the major flaws in the existing dogma.5 people found this helpfulHelpfulComment Report abuse
📷Stephanie Seneff5.0 out of 5 stars If you think you understand AIDS and cancer, think again!Reviewed in the United States on October 26, 2012Verified PurchaseThis is arguably the best book I have ever read, in terms of how it spoke to me. The author obviously is extremely well informed about biology, and the book is full of detailed accounts of how biology works. The hypothesis he proposes is a mind-bender: he makes a strong claim that AIDS and cancer are caused by an excessive cumulative exposure to oxides of nitrogen, which results in a steady drain of glutathione and other sulfur-containing metabolites.It will also make you seriously question the validity of "standard treatment" for diseases like AIDS and cancer.
So we have a situation where the alternative hypothesis put forth in 1993 has continued to be developed on and proving itself more and more valuable as a useful assumption to treat patients diagnosed with both cancer and AIDS however, as the title of the book suggests, despite building such a robust hypothesis this powerful argument still exists as a silent revolution within the medical community as with half a trillion dollars of tax payer dollars diverted in to HIV related research over the last 30 years, who would be willing to declare the HIV/AIDS hypothesis as dead? And even if they did, how would they overcome the incumbent assumptions regarding the disease when even esteemed academics such as Duesberg get turned in to a complete pariah when the medical/scientific/publishing apparatus declares you a AIDS Denialist. How many books have to get published, academics have to speak up in order to declare a hypothesis invalid and begin diverting those tax payer dollars towards a new line of inquiry which may in fact yield much more beneficial findings for global health?

THE OUT OF AFRICA THEORY

How was the Out of Africa Theory Established?
Out of Africa was only established in the 90’s during a debate as to the age of modern humans.
The development of genetic analysis tools in the 1980s helped scientists grow attracted to the out of Africa hypothesis. Matches between the DNA of living modern humans and fossil remains verified that H. sapiens evolved several hundred thousand years ago on African soil.
The theory explains that while numerous human-like species walked the planet, only one arose into modern man*.*

From wiki:
"There were at least several "out-of-Africa" dispersals of modern humans, possibly beginning as early as 270,000 years ago, including 215,000 years ago to at least Greece, and certainly via northern Africa about 130,000 to 115,000 years ago.These early waves appear to have mostly died out or retreated by 80,000 years ago.
The most significant "recent" wave took place about 70,000–50,000 years ago, via the so-called "Southern Route", spreading rapidly along the coast of Asia and reaching Australia by around 65,000–50,000 years ago,"
The Out of Africa Theory Has No Home
Accordingly, we can infer that Eve lived three times 50,000 to 60,000 years ago, or roughly 150,000 to 180,000 years ago.5
This declaration was regarded as the final word, and the resolution of "15 years of disagreement"6 between two branches of science. Wilson and Cann triumphantly proclaimed victory on behalf of the molecular geneticists declaring that "we won the argument, when the palaeontologists admitted we had been right and they had been wrong."7
With the case closed and bragging rights secured in perpetuity, science had once again provided certainty and an African ancestry. Or so it seemed. But not long after their paper was published Rebecca Cann realised they were mistaken. In 1982 she examined the mitochondrial DNA of 112 Indigenous people, including twelve full-descent Aboriginals, and the results were in total opposition to what they assumed was fully resolved.
Nevertheless, Cann was obliged to contradict a central tenet of their paper, stating that "mitochondrial DNA puts the origin of Homo sapiens much further back and indicates that the Australian Aboriginals arose 400,000 years ago from two distinct lineages,
The realignment and reversals were of immediate concern to Alan Wilson. If Cann was correct in detecting a "much higher number of mutations"11 they may as well tear up their original paper.
.......Upon receiving the results of his second mtDNA sampling Wilson immediately conceded the Out-of-Africa theory was wrong.......
Referring back to Wilson and Canns original calculations, their proposed timing of somewhere between 50-60,000 years stands on no less shaky ground than their genetic miscalculation. There are at least ten Australian sites claimed to be older than 60,000 years, granted every date is challenged by conservative critics, but even so, all are the products of respected academics.
What needs to be accepted is that if just one date proves to be correct, irrespective of whatever judgment is passed on the other nine, it can be confidently declared as a fact that Australia was not settled by African Homo sapiens 60,000 years ago. Whether the winning site turns out to be Lake George-fire-stick farming (120,000 years); Lake Eyre-skullcap (135,000 years); Jinmium-tools (176,000 years); Panaramittee-rock-engraving of saltwater crocodile (75,000 years); Rottnest Island-tools (70,000 years); Devonport-rock-engravings (>115,000 years); Jinmium-art (75-116,000 years); Great Barrier Reef-fire-stick farming (185,000 years); Lake Mungo (WLH3)-complete skeleton (61-65,000 years); or (WLH1)-cremated bones (61,000 years); one out of the ten is sufficient to deny African entry.
http://nationalunitygovernment.org/content/first-race-out-australia-not-africa-0

BIOLOGICAL LAWS

The main reason I structured this post the way I have is to emphasise the explanatory power of the different explanations for causation in a couple of controversial topics and how some hypotheses are favoured more than others in incumbent organisations which may have a conflict of interest in perpetuating the misunderstanding. In admitting the failure of the HIV AIDS hypothesis you are slaughtering a half a trillion tax payer dollar cash cow that's been paying your way for the last few decades. To accept the out of Australia theory over the out of Africa could similarly challenge the human ape common ancestor narrative as well.
A Law on the other hand, is something that is always the case. The Laws of thermodynamics can not be violated. There may be phenomena where there appears to be some violations as temporal oppositions but when seen nested within hierarchical systems do in fact adhere to these laws. In terms of Biology there are only a few listed on wikipedia as
https://en.wikipedia.org/wiki/Biological_rules
There are definitely a few interesting ones there that warrant further contemplation particularly with respect to temperatures and latitudes however, it may be worth considering if there are any biological laws that haven't been included in this wiki list. However what about the biological laws proposed by Dr Ryke Geerd Hamer?
Dr. med. Ryke Geerd Hamer was born on May 17, 1935 in Mettmann, Germany. He spent his childhood with his paternal grandparents in East Frisia. In 1953, he began to study medicine, theology, and physics at the University of Tuebingen. At the age of 22, he completed his master's degree in theology and then, four years later, received his professional license as a doctor of medicine. The following years he practiced at various university clinics in Germany.
In 1972, Dr. Hamer completed his specialization in internal medicine and began to work at the University clinic in Tuebingen as an internist in charge of cancer patients. At the same time, he ran a private practice with his wife Dr. Sigrid Hamer, whom he had met during their studies in Tuebingen. He also showed an extraordinary talent for inventing medical devices. Among others, he owns the patent for a non-traumatic scalpel (Hamer Scalpel) which cuts twenty times sharper than a razor blade, a special bone saw for plastic surgery, and a massage table that automatically adjusts to the body's contours.
His inventions provided Dr. Hamer and his family with the financial means to move to Italy, where he realized his plan to treat the sick in the slums of Rome free of charge. On August 18th, 1978, while in Rome, the Hamers received the shocking news that their son Dirk had been accidentally shot by the Italian Prince Victor Emanuel of Savoy. On December 7th, 1978, Dirk succumbed to the injuries and died in his father's arms. Dirk is buried under the city wall at the pyramid in Rome.
Shortly after Dirk's death, Dr. Hamer was diagnosed with testicular cancer. Since he had never been seriously ill, he postulated that the development of his cancer could be directly related to the unexpected loss of his son. In fact, he would eventually, in honor of Dirk, call this unexpected shock a DHS or “Dirk Hamer Syndrome”. Dirk's death and his own experience with cancer set Dr. Hamer on an extraordinary scientific journey.
At the time head internist of a cancer clinic at the University of Munich, he began to investigate his cancer patients' histories and soon learned that, like him, they all had experienced an unexpected shock of one sort or another. But he took his research even further. Pursuing the hypothesis that all bodily processes are controlled from the brain, he analyzed his patients' brain scans and compared them with their medical records and personal histories. To his amazement, he found a clear correlation between certain types of “conflict shocks”, how these shocks manifest themselves on the organ level as specific symptoms and how all this is connected to the brain. Until then, no studies had examined the role of the brain as the mediator between the psyche and a diseased organ.
Dr. Hamer established that every disease originates from a shock or trauma that catches an individual completely by surprise. The moment the unexpected conflict occurs, the shock strikes a specific, predetermined area in the brain causing a lesion (later called Hamer Focus or HH - Hamerscher Herd), visible on a brain scan as a set of sharp concentric rings. Before Dr. Hamer identified these ringed lesions on a brain scan, radiologists considered them as artifacts created by a glitch in the machine. But Siemens, a manufacturer of computer tomography equipment, certified that these target lesions cannot be artifacts because even when the tomography is repeated and taken from different angles, the same ring formation always appears in the same location.
The brain cells that receive the shock (DHS) send a biochemical signal to the corresponding body cells causing the growth of a tumor, a meltdown of tissue, or functional loss, depending on which part of the brain is involved. The reason why specific conflicts are irrefutably tied to specific areas in the brain is that during the development of the human organism each brain area was programmed to respond instantly to situations that could threaten survival. While the brainstem, the oldest part of the brain, is programmed with primordial conflicts related to breathing (death-fright conflicts) reproduction (procreation conflicts) and food (morsel conflicts), the cerebrum, the youngest part of the brain, correlates to more advanced matters (separation conflicts, territorial conflicts). Dr. Hamer also discovered that every disease progresses in two phases: first, a conflict-active phase, characterized by emotional distress, a lack of appetite, and sleeplessness, and then, provided the conflict can be resolved, a healing phase. This is the period in which the psyche, the brain and the affected organ undergo the phase of recovery, an often difficult process marked by fatigue, headaches, inflammation, “infections”, and pain.
Firmly anchored in the science of embryology and in full accordance with evolutionary logic, Dr. Hamer called his findings “The Five Biological Laws of the New Medicine”. Over the years, he was able to confirm his discoveries with over 40,000 case studies.
https://learninggnm.com/SBS/documents/verifications.html
https://learninggnm.com/SBS/documents/five_laws.html

FIRST BIOLOGICAL LAW (“The Iron Rule of Cancer”)

1st Criterion: Every “disease” - hereinafter called Significant Biological Special Program (SBS) - originates from a DHS (Dirk Hamer Syndrome), which is an unexpected, highly acute, and isolating conflict shock that occurs simultaneously in the psyche, the brain, and on the corresponding organ.2nd Criterion: The content of the conflict determines which organ will be affected and from which area of the brain the SBS will be controlled. 3rd Criterion: Every SBS runs synchronously on the level of the psyche, the brain, and the organ.
Severe malnutrition, poisoning, or an injury can result in the dysfunction of an organ without a DHS.

SECOND BIOLOGICAL LAW

Every SBS-Significant Biological Special Program runs in two phases provided there is a resolution of the conflict.
THE CONFLICT-ACTIVE PHASE (CA-Phase)
When the DHS occurs, the normal day-night-rhythm is instantly interrupted and the autonomic nervous system switches into lasting sympathicotonia and a prolonged state of stress with nervous restlessness, a fast heartbeat, elevated blood pressure, slow digestion, frequent urination, and little appetite. Since the blood vessels are constricted during stress, typical signs of conflict activity are cold hands, cold sweats, and the shivers. We therefore call the conflict-active phase also the COLD phase.
The PSYCHE is in a compulsive thinking mode. The constant dwelling over the conflict causes sleep disturbances (waking up shortly after falling asleep, usually around 3 o’clock in the morning). The extra waking hours and the total focus on the conflict serve to find a resolution to the conflict as soon as possible.
THE HEALING PHASE (PCL= post-conflictolysis)
With the resolution of the conflict, the autonomic nervous system switches into lasting vagotonia and a prolonged state of rest with fatigue but good appetite. Resting and the desire to eat provide the organism with the necessary energy for healing. If the healing phase is intense, the tiredness could be so overwhelming that one can hardly get out of bed. The need for sleep is particularly strong during the day (in conventional medicine, persistent tiredness is diagnosed as “chronic fatigue syndrome”). Accompanying symptoms are a slow pulse and low blood pressure. During vagotonia, the blood vessels expand causing warm hands and a warm skin. We therefore call the healing phase also the WARM phase.
The PSYCHE is in a state of relief.
If more tissue is required to facilitate a conflict resolution, the corresponding organ generates cell proliferation during the conflict-active phase. This process applies to all organs and tissues that are controlled by the brainstem and the cerebellum such as the lungs, liver, pancreas, colon, thyroid, or breast glands. In embryological terms, these organs derive from the endoderm or from the old mesoderm (see Third Biological Law).
If less tissue is required to facilitate a conflict resolution, the organ or tissue responds with cell loss. This process applies to all organs and tissues that are controlled from the cerebral medulla and the cerebral cortex such as the bones and joints, ovaries, testicles, coronary arteries, coronary veins, cervix, bronchi, larynx, and the skin. In embryological terms, these organs derive from the new mesoderm or from the ectoderm (see Third Biological Law
Diagram of the Two Phases
A “hanging healing” refers to the situation where the healing phase cannot be completed because of recurrent conflict relapses.

THIRD BIOLOGICAL LAW


Dr. Hamer's medical research is firmly anchored in the science of embryology. Taking into account the development of the fetus (ontogenesis) he discovered that the correlation between the psyche, the brain, and the organs is closely connected to the three embryonic germ layers (endoderm, mesoderm, ectoderm) from which all organs of the human body originate. The Third Biological Law shows that the location of the Hamer Focus in the brain as well as the cell proliferation or cell loss following a DHS are not accidental but part of a meaningful biological system inherent in every living organism. The Biological Special Programs of Nature are encoded in every human cell and thus inscribed in the DNA, the carrier of genetic information (see GNM Article “Understanding Genetic Diseases”).
Through analyzing and comparing thousands of brain scans Dr. Hamer found that organs originating from the same embryonic germ layer are controlled from the same part of the brain.

  • All organs that derive from the endoderm are controlled from the brainstem. Primitive life forms such as bacteria have only endodermal functions.
  • All organs that derive from the old mesoderm are controlled from the cerebellum.
  • All organs that derive from the new mesoderm are controlled from the cerebral medulla.
  • All organs that derive from the ectoderm are controlled from the cerebral cortex.

FOURTH BIOLOGICAL LAW

For the first 2.5 billion years, microbes were the only organisms inhabiting the earth. Gradually, they populated other life forms, including plants, animals, and humans. It is estimated that the number of microbial cells residing in the human body (known as the “human microbiome”) outnumbers the body cells almost 4 to 1. Owing to their symbiotic relationship with the human organism and their vital role in maintaining the body tissues, microbes have become indispensable for our survival.
NOTE: The placenta that connects the developing fetus to the uterus is not sterile, as previously thought, but harbors a rich collection of bacteria. Hence, bacteria assist the healing process already in the organism of the fetus! “For more than a century scientists have assumed that babies come into the world germ-free after nine months in a sterile womb. Not so, new studies find: Bacteria lurk in the placenta, amniotic fluid and umbilical cord, making the womb a germy place.” (Science News, May 28, 2014; see also "The Placenta Harbors a Unique Microbiome", Science Transational Medicine, May 21, 2014). Mycobacteria such as TB bacteria are also introduced to the newborn through the breast milk.
The theory that certain “diseases” are caused by “pathogenic microbes” is one of the most persistent doctrines of modern medicine. This general conception is largely attributable to the fact that microbes are present at the site of a “diseased” organ. And since the activity of microbes is accompanied by swelling, fever, inflammation, pus, discharge, and pain, microbes are believed to be the cause of “infectious diseases”. Similar to the idea that an “abnormal” growth of cancer cells leads to the development of a “malignant” tumor, it is wrongly assumed that microbes growing beyond their normal ranges (see immune system theory) results in virulent “infections”.
Microbes don’t cause diseases but play instead a vital role during the healing phase.
The Fourth Biological Law shows that so-called “infectious diseases” occur exclusively in the second phase of a Biological Special Program, where the organism uses the microbes to optimize healing. During their activities microbes require a warm environment, hence, the development of an inflammation and fever. Microbes also need an acidic milieu, which is suitably provided through the vagotonic state that is dominant in every healing phase. The onset of an “infection” is therefore not, as presumed, brought on by an imbalanced pH level (a “wrong diet”) but rather by the transition from the conflict-active phase into the healing phase.
NOTE: Microbes are endemic. They live in harmony with all organisms of the ecological milieu in which they have developed over millions of years. Contact with microbes that are foreign to the human body, for example through traveling abroad, does not cause per se a “disease”. However, if, let’s say, a European happens to resolve a particular conflict in the tropics and comes in contact with local microbes, the related organ will use them for the healing process. Since the body is not accustomed to these exotic microorganisms, the healing symptoms can be quite severe.

Diseases are not contagious!
If two or more people happen to have the same symptoms, for example, a cold, diarrhea, or a stomach flu, this means that all of them are in the healing phase of the same type of conflict (stink conflict, indigestible morsel conflict, territorial anger conflict) that took place, let’s say, at school, at home, or at work.

FIFTH BIOLOGICAL LAW - THE QUINTESSENCE

Every so-called disease is part of a Significant Biological Special Program of Nature created to assists an organism (humans and animals alike) during unexpected distress.
Dr. Hamer: “All so-called diseases have a special biological meaning. While we used to regard Mother Nature as fallible and had the audacity to believe that She constantly made mistakes and caused breakdowns (malignant, senseless, degenerative cancerous growths, etc.) we can now see, as the scales fall from our eyes, that it was our ignorance and pride that were and are the only foolishness in our cosmos. Blinded, we brought upon ourselves this senseless, soulless and brutal medicine. Full of wonder, we can now understand for the first time that Nature is orderly and that every occurrence in Nature is meaningful, even in the framework of the whole. Nothing in Nature is meaningless, malignant or diseased.”

WHY AREN'T THESE LAWS IN WIKIPEDIA?

In October 1981, Dr. Hamer submitted his research to the University of Tuebingen as a post-doctoral thesis. The objective was to have his findings tested on equivalent cases so that the New Medicine could be taught to all medical students and that patients could benefit from the discoveries as soon as possible. But to his great surprise, the University committee rejected his work and refused to evaluate his thesis. This is an unprecedented case in the history of universities! There was yet another surprise. Shortly after he had handed in his thesis, Dr. Hamer was given the ultimatum to either deny his findings or his contract would not be renewed. It was extremely difficult for him to understand why he was being expelled from the clinic for presenting well-substantiated scientific findings. Dr. Hamer stood his ground. After his dismissal, he retreated to his private practice where he continued his research. Several attempts to open a private clinic failed because of concerted efforts opposing it. Letters of Dr. Hamer's patients to health officials remained unanswered or were returned with the comment: “Not applicable!”. To this day, the firm position of the authorities has not changed.
The harassment of Dr. Hamer culminated in 1989, when a court sentence stopped him from practicing medicine. Despite the fact that his scientific work had never been disproved, he lost, at the age of 54, his medical license on the grounds that he refused to renounce his findings on the origin of cancer and to conform to the principles of official medicine. Deprived of a medical license, Dr. Hamer now relied on other doctors to obtain brain scans and patients' records. But he was determined to continue his work. By 1987 Dr. Hamer had already analyzed over 10,000 cases and was able to expand his discovery of the Five Biological Laws to practically all diseases known in medicine. Meanwhile, the press and the medical establishment stopped at nothing to attack him and his work. Tabloid journalists and medical “experts” portray Dr. Hamer as a charlatan, a self-proclaimed miracle healer, a cult leader, an irrational outsider, or an insane criminal who denies cancer patients the ‘life-saving’ conventional treatments.
In 1997, Dr. Hamer was arrested and sentenced to 19 months in prison for having given three people free medical information without a medical license. By contrast, in 1991, thirteen years after he had killed Dirk Hamer, Victor Emanuel of Savoy had been sentenced to a mere 6 months probation for the illegal possession of a weapon. When Dr. Hamer was arrested, the police searched his patient files. Subsequently, one public prosecutor was forced to admit during the trial that after more than five years, of 6500 patients with mostly ‘terminal’ cancer, 6000 were still alive. And so, ironically, it was his opponents that provided the actual statistics attesting to German New Medicine's remarkable success rate. Yet, to this day, the University of Tuebingen refuses, despite court orders in 1986 and 1994, to test Dr. Hamer's scientific work. Similarly, official medicine refuses to endorse GNM despite its numerous verifications by both physicians and professorial associations.


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2020.09.06 15:39 whipnil Medical Myths VII: Hypothesis, Theory, Law

From Merriam Webster-

The Difference Between Hypothesis and Theory

A hypothesis is an assumption, an idea that is proposed for the sake of argument so that it can be tested to see if it might be true.
In the scientific method, the hypothesis is constructed before any applicable research has been done, apart from a basic background review. You ask a question, read up on what has been studied before, and then form a hypothesis.
A hypothesis is usually tentative; it's an assumption or suggestion made strictly for the objective of being tested.
A theory, in contrast, is a principle that has been formed as an attempt to explain things that have already been substantiated by data. It is used in the names of a number of principles accepted in the scientific community, such as the Big Bang Theory. Because of the rigours of experimentation and control, it is understood to be more likely to be true than a hypothesis is.
In non-scientific use, however, hypothesis and theory are often used interchangeably to mean simply an idea, speculation, or hunch, with theory being the more common choice.
Since this casual use does away with the distinctions upheld by the scientific community, hypothesis and theory are prone to being wrongly interpreted even when they are encountered in scientific contexts—or at least, contexts that allude to scientific study without making the critical distinction that scientists employ when weighing hypotheses and theories.
The most common occurrence is when theory is interpreted—and sometimes even gleefully seized upon—to mean something having less truth value than other scientific principles. (The word law applies to principles so firmly established that they are almost never questioned, such as the law of gravity.)
This mistake is one of projection: since we use theory in general to mean something lightly speculated, then it's implied that scientists must be talking about the same level of uncertainty when they use theory to refer to their well-tested and reasoned principles.
The distinction has come to the forefront particularly on occasions when the content of science curricula in schools has been challenged—notably, when a school board in Georgia put stickers on textbooks stating that evolution was "a theory, not a fact, regarding the origin of living things." As Kenneth R. Miller, a cell biologist at Brown University, has said, a theory "doesn’t mean a hunch or a guess. A theory is a system of explanations that ties together a whole bunch of facts. It not only explains those facts, but predicts what you ought to find from other observations and experiments.”
While theories are never completely infallible, they form the basis of scientific reasoning because, as Miller said "to the best of our ability, we’ve tested them, and they’ve held up."
THE HIV/AIDS HYPOTHESIS
HIV-AIDS hypothesis out of touch with South African AIDS – A new perspective (pdf warning)
"A recent study by Chigwedere et al., ‘‘Estimating the lost benefits of antiretroviral drug use in South Africa”, claims that during the period from 2000 to 2005 about 330,000 South African AIDS-deaths were caused by the Human Immunodeficiency Virus (HIV) per year that could have been prevented by available anti-HIV drugs. The study blamed those who question the hypothesis that HIV is the cause of AIDS, particularly former South African President Thabo Mbeki and one of us, for not preventing these deaths by anti-HIV treatments"
"We conclude that the claims that HIV has caused huge losses of African lives are unconfirmed and that HIV is not sufficient or even necessary to cause the previously known diseases, now called AIDS in the presence of antibody against HIV. Further we call into question the claim that HIV antibody-positives would benefit from anti-HIV drugs, because these drugs are inevitably toxic and because there is as yet no proof that HIV causes AIDS."
Fallacies in Modern Medicine - The HIV/AIDS Hypothesis
In essence HIV has never been isolated and characterised. There are no clinical symptoms specific to AIDS. All AIDS related diseases can be caused by other factors with the pathologies noted in the gayUS community such as the Kaposi Sarcomas (KS) being explainable by oxidative stress and disruption to Nitrous Oxide pathways, while there is almost never KS in the African cohort and all the AIDS related pathologies there explainable by poor nutrition.
ALTERNATIVE HYPOTHESIS
Oxidative Stress, HIV and AIDS (pdf warning)
"It has been accepted by researchers at the CDC that KS (Kaposi's sarcoma), the first and most specific of the AIDS indicator diseases, for which the explanation of the HIV hypothesis was put forward by Gallo in 1982, is not caused directly or indirectly by HIV (Beral et al., 1990). On the other hand, recent empirical observations from three seemingly unrelated areas of AIDS research are in agreement with the hypothesis that oxidative mechanisms play a critical role in HIV expression and AIDS development.
"Thus, the systemic decrease of glutathione concentration in HIV seropositive individuals may result from both, decrease in synthesis and increased degradation. The oxidative stress to which the AIDS patients are subjected would lead to cellular anomalies in many cells, including lymphocytes, resulting in opportunistic infection, immunological abnormalities and neoplasia. All this argues in favour of oxidation as being a critical factor in the pathogenesis of AIDS and HIV expression."
This paper was published in 1993
The Silent Revolution in Cancer and AIDS Medicine
📷Michael McEvoy5.0 out of 5 stars Remarkable Work, Incredibly Important Book For Intensive ResearchersReviewed in the United States on November 22, 2018Verified PurchaseDr. Heinrich Kremer has written a masterful book that describes with intricate details the major problems with the HIV/AIDS research and theory. Kremer highlights the reality of functional TH2 imbalance within the immune cells as a counterregulatory shift set off by longterm oxidative stress. Mitochondrial dysfunction, coupled by thiol deficiency and redox disequilibrium leads to cachexia, immunological dysfunction in both AIDS and cancer. Toxic drugs perpetuate the problem of chronic thiol depletion and redox dysfunction. Must read for anyone wanting a deep dive into biochemistry, the historical context of AIDS, and the major flaws in the existing dogma.5 people found this helpfulHelpfulComment Report abuse
📷Stephanie Seneff5.0 out of 5 stars If you think you understand AIDS and cancer, think again!Reviewed in the United States on October 26, 2012Verified PurchaseThis is arguably the best book I have ever read, in terms of how it spoke to me. The author obviously is extremely well informed about biology, and the book is full of detailed accounts of how biology works. The hypothesis he proposes is a mind-bender: he makes a strong claim that AIDS and cancer are caused by an excessive cumulative exposure to oxides of nitrogen, which results in a steady drain of glutathione and other sulfur-containing metabolites.It will also make you seriously question the validity of "standard treatment" for diseases like AIDS and cancer.
So we have a situation where the alternative hypothesis put forth in 1993 has continued to be developed on and proving itself more and more valuable as a useful assumption to treat patients diagnosed with both cancer and AIDS however, as the title of the book suggests, despite building such a robust hypothesis this powerful argument still exists as a silent revolution within the medical community as with half a trillion dollars of tax payer dollars diverted in to HIV related research over the last 30 years, who would be willing to declare the HIV/AIDS hypothesis as dead? And even if they did, how would they overcome the incumbent assumptions regarding the disease when even esteemed academics such as Duesberg get turned in to a complete pariah when the medical/scientific/publishing apparatus declares you a AIDS Denialist. How many books have to get published, academics have to speak up in order to declare a hypothesis invalid and begin diverting those tax payer dollars towards a new line of inquiry which may in fact yield much more beneficial findings for global health?

THE OUT OF AFRICA THEORY

How was the Out of Africa Theory Established?
Out of Africa was only established in the 90’s during a debate as to the age of modern humans.
The development of genetic analysis tools in the 1980s helped scientists grow attracted to the out of Africa hypothesis. Matches between the DNA of living modern humans and fossil remains verified that H. sapiens evolved several hundred thousand years ago on African soil.
The theory explains that while numerous human-like species walked the planet, only one arose into modern man*.*

From wiki:
"There were at least several "out-of-Africa" dispersals of modern humans, possibly beginning as early as 270,000 years ago, including 215,000 years ago to at least Greece, and certainly via northern Africa about 130,000 to 115,000 years ago.These early waves appear to have mostly died out or retreated by 80,000 years ago.
The most significant "recent" wave took place about 70,000–50,000 years ago, via the so-called "Southern Route", spreading rapidly along the coast of Asia and reaching Australia by around 65,000–50,000 years ago,"
The Out of Africa Theory Has No Home
Accordingly, we can infer that Eve lived three times 50,000 to 60,000 years ago, or roughly 150,000 to 180,000 years ago.5
This declaration was regarded as the final word, and the resolution of "15 years of disagreement"6 between two branches of science. Wilson and Cann triumphantly proclaimed victory on behalf of the molecular geneticists declaring that "we won the argument, when the palaeontologists admitted we had been right and they had been wrong."7
With the case closed and bragging rights secured in perpetuity, science had once again provided certainty and an African ancestry. Or so it seemed. But not long after their paper was published Rebecca Cann realised they were mistaken. In 1982 she examined the mitochondrial DNA of 112 Indigenous people, including twelve full-descent Aboriginals, and the results were in total opposition to what they assumed was fully resolved.
Nevertheless, Cann was obliged to contradict a central tenet of their paper, stating that "mitochondrial DNA puts the origin of Homo sapiens much further back and indicates that the Australian Aboriginals arose 400,000 years ago from two distinct lineages,
The realignment and reversals were of immediate concern to Alan Wilson. If Cann was correct in detecting a "much higher number of mutations"11 they may as well tear up their original paper.
.......Upon receiving the results of his second mtDNA sampling Wilson immediately conceded the Out-of-Africa theory was wrong.......
Referring back to Wilson and Canns original calculations, their proposed timing of somewhere between 50-60,000 years stands on no less shaky ground than their genetic miscalculation. There are at least ten Australian sites claimed to be older than 60,000 years, granted every date is challenged by conservative critics, but even so, all are the products of respected academics.
What needs to be accepted is that if just one date proves to be correct, irrespective of whatever judgment is passed on the other nine, it can be confidently declared as a fact that Australia was not settled by African Homo sapiens 60,000 years ago. Whether the winning site turns out to be Lake George-fire-stick farming (120,000 years); Lake Eyre-skullcap (135,000 years); Jinmium-tools (176,000 years); Panaramittee-rock-engraving of saltwater crocodile (75,000 years); Rottnest Island-tools (70,000 years); Devonport-rock-engravings (>115,000 years); Jinmium-art (75-116,000 years); Great Barrier Reef-fire-stick farming (185,000 years); Lake Mungo (WLH3)-complete skeleton (61-65,000 years); or (WLH1)-cremated bones (61,000 years); one out of the ten is sufficient to deny African entry.
http://nationalunitygovernment.org/content/first-race-out-australia-not-africa-0

BIOLOGICAL LAWS

The main reason I structured this post the way I have is to emphasise the explanatory power of the different explanations for causation in a couple of controversial topics and how some hypotheses are favoured more than others in incumbent organisations which may have a conflict of interest in perpetuating the misunderstanding. In admitting the failure of the HIV AIDS hypothesis you are slaughtering a half a trillion tax payer dollar cash cow that's been paying your way for the last few decades. To accept the out of Australia theory over the out of Africa could similarly challenge the human ape common ancestor narrative as well.
A Law on the other hand, is something that is always the case. The Laws of thermodynamics can not be violated. There may be phenomena where there appears to be some violations as temporal oppositions but when seen nested within hierarchical systems do in fact adhere to these laws. In terms of Biology there are only a few listed on wikipedia as
https://en.wikipedia.org/wiki/Biological_rules
There are definitely a few interesting ones there that warrant further contemplation particularly with respect to temperatures and latitudes however, it may be worth considering if there are any biological laws that haven't been included in this wiki list. However what about the biological laws proposed by Dr Ryke Geerd Hamer?
Dr. med. Ryke Geerd Hamer was born on May 17, 1935 in Mettmann, Germany. He spent his childhood with his paternal grandparents in East Frisia. In 1953, he began to study medicine, theology, and physics at the University of Tuebingen. At the age of 22, he completed his master's degree in theology and then, four years later, received his professional license as a doctor of medicine. The following years he practiced at various university clinics in Germany.
In 1972, Dr. Hamer completed his specialization in internal medicine and began to work at the University clinic in Tuebingen as an internist in charge of cancer patients. At the same time, he ran a private practice with his wife Dr. Sigrid Hamer, whom he had met during their studies in Tuebingen. He also showed an extraordinary talent for inventing medical devices. Among others, he owns the patent for a non-traumatic scalpel (Hamer Scalpel) which cuts twenty times sharper than a razor blade, a special bone saw for plastic surgery, and a massage table that automatically adjusts to the body's contours.
His inventions provided Dr. Hamer and his family with the financial means to move to Italy, where he realized his plan to treat the sick in the slums of Rome free of charge. On August 18th, 1978, while in Rome, the Hamers received the shocking news that their son Dirk had been accidentally shot by the Italian Prince Victor Emanuel of Savoy. On December 7th, 1978, Dirk succumbed to the injuries and died in his father's arms. Dirk is buried under the city wall at the pyramid in Rome.
Shortly after Dirk's death, Dr. Hamer was diagnosed with testicular cancer. Since he had never been seriously ill, he postulated that the development of his cancer could be directly related to the unexpected loss of his son. In fact, he would eventually, in honor of Dirk, call this unexpected shock a DHS or “Dirk Hamer Syndrome”. Dirk's death and his own experience with cancer set Dr. Hamer on an extraordinary scientific journey.
At the time head internist of a cancer clinic at the University of Munich, he began to investigate his cancer patients' histories and soon learned that, like him, they all had experienced an unexpected shock of one sort or another. But he took his research even further. Pursuing the hypothesis that all bodily processes are controlled from the brain, he analyzed his patients' brain scans and compared them with their medical records and personal histories. To his amazement, he found a clear correlation between certain types of “conflict shocks”, how these shocks manifest themselves on the organ level as specific symptoms and how all this is connected to the brain. Until then, no studies had examined the role of the brain as the mediator between the psyche and a diseased organ.
Dr. Hamer established that every disease originates from a shock or trauma that catches an individual completely by surprise. The moment the unexpected conflict occurs, the shock strikes a specific, predetermined area in the brain causing a lesion (later called Hamer Focus or HH - Hamerscher Herd), visible on a brain scan as a set of sharp concentric rings. Before Dr. Hamer identified these ringed lesions on a brain scan, radiologists considered them as artifacts created by a glitch in the machine. But Siemens, a manufacturer of computer tomography equipment, certified that these target lesions cannot be artifacts because even when the tomography is repeated and taken from different angles, the same ring formation always appears in the same location.
The brain cells that receive the shock (DHS) send a biochemical signal to the corresponding body cells causing the growth of a tumor, a meltdown of tissue, or functional loss, depending on which part of the brain is involved. The reason why specific conflicts are irrefutably tied to specific areas in the brain is that during the development of the human organism each brain area was programmed to respond instantly to situations that could threaten survival. While the brainstem, the oldest part of the brain, is programmed with primordial conflicts related to breathing (death-fright conflicts) reproduction (procreation conflicts) and food (morsel conflicts), the cerebrum, the youngest part of the brain, correlates to more advanced matters (separation conflicts, territorial conflicts). Dr. Hamer also discovered that every disease progresses in two phases: first, a conflict-active phase, characterized by emotional distress, a lack of appetite, and sleeplessness, and then, provided the conflict can be resolved, a healing phase. This is the period in which the psyche, the brain and the affected organ undergo the phase of recovery, an often difficult process marked by fatigue, headaches, inflammation, “infections”, and pain.
Firmly anchored in the science of embryology and in full accordance with evolutionary logic, Dr. Hamer called his findings “The Five Biological Laws of the New Medicine”. Over the years, he was able to confirm his discoveries with over 40,000 case studies.
https://learninggnm.com/SBS/documents/verifications.html
https://learninggnm.com/SBS/documents/five_laws.html

FIRST BIOLOGICAL LAW (“The Iron Rule of Cancer”)

1st Criterion: Every “disease” - hereinafter called Significant Biological Special Program (SBS) - originates from a DHS (Dirk Hamer Syndrome), which is an unexpected, highly acute, and isolating conflict shock that occurs simultaneously in the psyche, the brain, and on the corresponding organ.2nd Criterion: The content of the conflict determines which organ will be affected and from which area of the brain the SBS will be controlled. 3rd Criterion: Every SBS runs synchronously on the level of the psyche, the brain, and the organ.
Severe malnutrition, poisoning, or an injury can result in the dysfunction of an organ without a DHS.

SECOND BIOLOGICAL LAW

Every SBS-Significant Biological Special Program runs in two phases provided there is a resolution of the conflict.
THE CONFLICT-ACTIVE PHASE (CA-Phase)
When the DHS occurs, the normal day-night-rhythm is instantly interrupted and the autonomic nervous system switches into lasting sympathicotonia and a prolonged state of stress with nervous restlessness, a fast heartbeat, elevated blood pressure, slow digestion, frequent urination, and little appetite. Since the blood vessels are constricted during stress, typical signs of conflict activity are cold hands, cold sweats, and the shivers. We therefore call the conflict-active phase also the COLD phase.
The PSYCHE is in a compulsive thinking mode. The constant dwelling over the conflict causes sleep disturbances (waking up shortly after falling asleep, usually around 3 o’clock in the morning). The extra waking hours and the total focus on the conflict serve to find a resolution to the conflict as soon as possible.
THE HEALING PHASE (PCL= post-conflictolysis)
With the resolution of the conflict, the autonomic nervous system switches into lasting vagotonia and a prolonged state of rest with fatigue but good appetite. Resting and the desire to eat provide the organism with the necessary energy for healing. If the healing phase is intense, the tiredness could be so overwhelming that one can hardly get out of bed. The need for sleep is particularly strong during the day (in conventional medicine, persistent tiredness is diagnosed as “chronic fatigue syndrome”). Accompanying symptoms are a slow pulse and low blood pressure. During vagotonia, the blood vessels expand causing warm hands and a warm skin. We therefore call the healing phase also the WARM phase.
The PSYCHE is in a state of relief.
If more tissue is required to facilitate a conflict resolution, the corresponding organ generates cell proliferation during the conflict-active phase. This process applies to all organs and tissues that are controlled by the brainstem and the cerebellum such as the lungs, liver, pancreas, colon, thyroid, or breast glands. In embryological terms, these organs derive from the endoderm or from the old mesoderm (see Third Biological Law).
If less tissue is required to facilitate a conflict resolution, the organ or tissue responds with cell loss. This process applies to all organs and tissues that are controlled from the cerebral medulla and the cerebral cortex such as the bones and joints, ovaries, testicles, coronary arteries, coronary veins, cervix, bronchi, larynx, and the skin. In embryological terms, these organs derive from the new mesoderm or from the ectoderm (see Third Biological Law
Diagram of the Two Phases
A “hanging healing” refers to the situation where the healing phase cannot be completed because of recurrent conflict relapses.

THIRD BIOLOGICAL LAW


Dr. Hamer's medical research is firmly anchored in the science of embryology. Taking into account the development of the fetus (ontogenesis) he discovered that the correlation between the psyche, the brain, and the organs is closely connected to the three embryonic germ layers (endoderm, mesoderm, ectoderm) from which all organs of the human body originate. The Third Biological Law shows that the location of the Hamer Focus in the brain as well as the cell proliferation or cell loss following a DHS are not accidental but part of a meaningful biological system inherent in every living organism. The Biological Special Programs of Nature are encoded in every human cell and thus inscribed in the DNA, the carrier of genetic information (see GNM Article “Understanding Genetic Diseases”).
Through analyzing and comparing thousands of brain scans Dr. Hamer found that organs originating from the same embryonic germ layer are controlled from the same part of the brain.

  • All organs that derive from the endoderm are controlled from the brainstem. Primitive life forms such as bacteria have only endodermal functions.
  • All organs that derive from the old mesoderm are controlled from the cerebellum.
  • All organs that derive from the new mesoderm are controlled from the cerebral medulla.
  • All organs that derive from the ectoderm are controlled from the cerebral cortex.

FOURTH BIOLOGICAL LAW

For the first 2.5 billion years, microbes were the only organisms inhabiting the earth. Gradually, they populated other life forms, including plants, animals, and humans. It is estimated that the number of microbial cells residing in the human body (known as the “human microbiome”) outnumbers the body cells almost 4 to 1. Owing to their symbiotic relationship with the human organism and their vital role in maintaining the body tissues, microbes have become indispensable for our survival.
NOTE: The placenta that connects the developing fetus to the uterus is not sterile, as previously thought, but harbors a rich collection of bacteria. Hence, bacteria assist the healing process already in the organism of the fetus! “For more than a century scientists have assumed that babies come into the world germ-free after nine months in a sterile womb. Not so, new studies find: Bacteria lurk in the placenta, amniotic fluid and umbilical cord, making the womb a germy place.” (Science News, May 28, 2014; see also "The Placenta Harbors a Unique Microbiome", Science Transational Medicine, May 21, 2014). Mycobacteria such as TB bacteria are also introduced to the newborn through the breast milk.
The theory that certain “diseases” are caused by “pathogenic microbes” is one of the most persistent doctrines of modern medicine. This general conception is largely attributable to the fact that microbes are present at the site of a “diseased” organ. And since the activity of microbes is accompanied by swelling, fever, inflammation, pus, discharge, and pain, microbes are believed to be the cause of “infectious diseases”. Similar to the idea that an “abnormal” growth of cancer cells leads to the development of a “malignant” tumor, it is wrongly assumed that microbes growing beyond their normal ranges (see immune system theory) results in virulent “infections”.
Microbes don’t cause diseases but play instead a vital role during the healing phase.
The Fourth Biological Law shows that so-called “infectious diseases” occur exclusively in the second phase of a Biological Special Program, where the organism uses the microbes to optimize healing. During their activities microbes require a warm environment, hence, the development of an inflammation and fever. Microbes also need an acidic milieu, which is suitably provided through the vagotonic state that is dominant in every healing phase. The onset of an “infection” is therefore not, as presumed, brought on by an imbalanced pH level (a “wrong diet”) but rather by the transition from the conflict-active phase into the healing phase.
NOTE: Microbes are endemic. They live in harmony with all organisms of the ecological milieu in which they have developed over millions of years. Contact with microbes that are foreign to the human body, for example through traveling abroad, does not cause per se a “disease”. However, if, let’s say, a European happens to resolve a particular conflict in the tropics and comes in contact with local microbes, the related organ will use them for the healing process. Since the body is not accustomed to these exotic microorganisms, the healing symptoms can be quite severe.

Diseases are not contagious!
If two or more people happen to have the same symptoms, for example, a cold, diarrhea, or a stomach flu, this means that all of them are in the healing phase of the same type of conflict (stink conflict, indigestible morsel conflict, territorial anger conflict) that took place, let’s say, at school, at home, or at work.

FIFTH BIOLOGICAL LAW - THE QUINTESSENCE

Every so-called disease is part of a Significant Biological Special Program of Nature created to assists an organism (humans and animals alike) during unexpected distress.
Dr. Hamer: “All so-called diseases have a special biological meaning. While we used to regard Mother Nature as fallible and had the audacity to believe that She constantly made mistakes and caused breakdowns (malignant, senseless, degenerative cancerous growths, etc.) we can now see, as the scales fall from our eyes, that it was our ignorance and pride that were and are the only foolishness in our cosmos. Blinded, we brought upon ourselves this senseless, soulless and brutal medicine. Full of wonder, we can now understand for the first time that Nature is orderly and that every occurrence in Nature is meaningful, even in the framework of the whole. Nothing in Nature is meaningless, malignant or diseased.”

WHY AREN'T THESE LAWS IN WIKIPEDIA?

In October 1981, Dr. Hamer submitted his research to the University of Tuebingen as a post-doctoral thesis. The objective was to have his findings tested on equivalent cases so that the New Medicine could be taught to all medical students and that patients could benefit from the discoveries as soon as possible. But to his great surprise, the University committee rejected his work and refused to evaluate his thesis. This is an unprecedented case in the history of universities! There was yet another surprise. Shortly after he had handed in his thesis, Dr. Hamer was given the ultimatum to either deny his findings or his contract would not be renewed. It was extremely difficult for him to understand why he was being expelled from the clinic for presenting well-substantiated scientific findings. Dr. Hamer stood his ground. After his dismissal, he retreated to his private practice where he continued his research. Several attempts to open a private clinic failed because of concerted efforts opposing it. Letters of Dr. Hamer's patients to health officials remained unanswered or were returned with the comment: “Not applicable!”. To this day, the firm position of the authorities has not changed.
The harassment of Dr. Hamer culminated in 1989, when a court sentence stopped him from practicing medicine. Despite the fact that his scientific work had never been disproved, he lost, at the age of 54, his medical license on the grounds that he refused to renounce his findings on the origin of cancer and to conform to the principles of official medicine. Deprived of a medical license, Dr. Hamer now relied on other doctors to obtain brain scans and patients' records. But he was determined to continue his work. By 1987 Dr. Hamer had already analyzed over 10,000 cases and was able to expand his discovery of the Five Biological Laws to practically all diseases known in medicine. Meanwhile, the press and the medical establishment stopped at nothing to attack him and his work. Tabloid journalists and medical “experts” portray Dr. Hamer as a charlatan, a self-proclaimed miracle healer, a cult leader, an irrational outsider, or an insane criminal who denies cancer patients the ‘life-saving’ conventional treatments.
In 1997, Dr. Hamer was arrested and sentenced to 19 months in prison for having given three people free medical information without a medical license. By contrast, in 1991, thirteen years after he had killed Dirk Hamer, Victor Emanuel of Savoy had been sentenced to a mere 6 months probation for the illegal possession of a weapon. When Dr. Hamer was arrested, the police searched his patient files. Subsequently, one public prosecutor was forced to admit during the trial that after more than five years, of 6500 patients with mostly ‘terminal’ cancer, 6000 were still alive. And so, ironically, it was his opponents that provided the actual statistics attesting to German New Medicine's remarkable success rate. Yet, to this day, the University of Tuebingen refuses, despite court orders in 1986 and 1994, to test Dr. Hamer's scientific work. Similarly, official medicine refuses to endorse GNM despite its numerous verifications by both physicians and professorial associations.


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2020.09.06 15:38 Zenn_diagram My data table isn't working - I get an "Input cell reference is not valid error"

Hi - I'd like to create a data table showing the sensitivity of return on assets (ROA) to price paid for a company, with the price paid being the input cell. The ROA is EBIT/Net assets, and the price paid is very early in the Net Assets calculation (i.e. the price paid determines the net assets through calculating the intangibles, depreciation, non-depreciating assets etc.).
How do I make a data table knowing this? In my data table, the current formula is =EBIT / ROA, with the input cell being price paid which is on another tab. I get "Input cell reference is not valid".

UPDATE - Was previously removed for non-conformance with Rule 1. Apologies to everyone I might have offended.
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2020.09.06 15:37 whipnil Medical Myths VII: Hypothesis, Theory, Law

From Merriam Webster-

The Difference Between Hypothesis and Theory

A hypothesis is an assumption, an idea that is proposed for the sake of argument so that it can be tested to see if it might be true.
In the scientific method, the hypothesis is constructed before any applicable research has been done, apart from a basic background review. You ask a question, read up on what has been studied before, and then form a hypothesis.
A hypothesis is usually tentative; it's an assumption or suggestion made strictly for the objective of being tested.
A theory, in contrast, is a principle that has been formed as an attempt to explain things that have already been substantiated by data. It is used in the names of a number of principles accepted in the scientific community, such as the Big Bang Theory. Because of the rigours of experimentation and control, it is understood to be more likely to be true than a hypothesis is.
In non-scientific use, however, hypothesis and theory are often used interchangeably to mean simply an idea, speculation, or hunch, with theory being the more common choice.
Since this casual use does away with the distinctions upheld by the scientific community, hypothesis and theory are prone to being wrongly interpreted even when they are encountered in scientific contexts—or at least, contexts that allude to scientific study without making the critical distinction that scientists employ when weighing hypotheses and theories.
The most common occurrence is when theory is interpreted—and sometimes even gleefully seized upon—to mean something having less truth value than other scientific principles. (The word law applies to principles so firmly established that they are almost never questioned, such as the law of gravity.)
This mistake is one of projection: since we use theory in general to mean something lightly speculated, then it's implied that scientists must be talking about the same level of uncertainty when they use theory to refer to their well-tested and reasoned principles.
The distinction has come to the forefront particularly on occasions when the content of science curricula in schools has been challenged—notably, when a school board in Georgia put stickers on textbooks stating that evolution was "a theory, not a fact, regarding the origin of living things." As Kenneth R. Miller, a cell biologist at Brown University, has said, a theory "doesn’t mean a hunch or a guess. A theory is a system of explanations that ties together a whole bunch of facts. It not only explains those facts, but predicts what you ought to find from other observations and experiments.”
While theories are never completely infallible, they form the basis of scientific reasoning because, as Miller said "to the best of our ability, we’ve tested them, and they’ve held up."
THE HIV/AIDS HYPOTHESIS
HIV-AIDS hypothesis out of touch with South African AIDS – A new perspective (pdf warning)
"A recent study by Chigwedere et al., ‘‘Estimating the lost benefits of antiretroviral drug use in South Africa”, claims that during the period from 2000 to 2005 about 330,000 South African AIDS-deaths were caused by the Human Immunodeficiency Virus (HIV) per year that could have been prevented by available anti-HIV drugs. The study blamed those who question the hypothesis that HIV is the cause of AIDS, particularly former South African President Thabo Mbeki and one of us, for not preventing these deaths by anti-HIV treatments"
"We conclude that the claims that HIV has caused huge losses of African lives are unconfirmed and that HIV is not sufficient or even necessary to cause the previously known diseases, now called AIDS in the presence of antibody against HIV. Further we call into question the claim that HIV antibody-positives would benefit from anti-HIV drugs, because these drugs are inevitably toxic and because there is as yet no proof that HIV causes AIDS."
Fallacies in Modern Medicine - The HIV/AIDS Hypothesis
In essence HIV has never been isolated and characterised. There are no clinical symptoms specific to AIDS. All AIDS related diseases can be caused by other factors with the pathologies noted in the gayUS community such as the Kaposi Sarcomas (KS) being explainable by oxidative stress and disruption to Nitrous Oxide pathways, while there is almost never KS in the African cohort and all the AIDS related pathologies there explainable by poor nutrition.
ALTERNATIVE HYPOTHESIS
Oxidative Stress, HIV and AIDS (pdf warning)
"It has been accepted by researchers at the CDC that KS (Kaposi's sarcoma), the first and most specific of the AIDS indicator diseases, for which the explanation of the HIV hypothesis was put forward by Gallo in 1982, is not caused directly or indirectly by HIV (Beral et al., 1990). On the other hand, recent empirical observations from three seemingly unrelated areas of AIDS research are in agreement with the hypothesis that oxidative mechanisms play a critical role in HIV expression and AIDS development.
"Thus, the systemic decrease of glutathione concentration in HIV seropositive individuals may result from both, decrease in synthesis and increased degradation. The oxidative stress to which the AIDS patients are subjected would lead to cellular anomalies in many cells, including lymphocytes, resulting in opportunistic infection, immunological abnormalities and neoplasia. All this argues in favour of oxidation as being a critical factor in the pathogenesis of AIDS and HIV expression."
This paper was published in 1993
The Silent Revolution in Cancer and AIDS Medicine
📷Michael McEvoy5.0 out of 5 stars Remarkable Work, Incredibly Important Book For Intensive ResearchersReviewed in the United States on November 22, 2018Verified PurchaseDr. Heinrich Kremer has written a masterful book that describes with intricate details the major problems with the HIV/AIDS research and theory. Kremer highlights the reality of functional TH2 imbalance within the immune cells as a counterregulatory shift set off by longterm oxidative stress. Mitochondrial dysfunction, coupled by thiol deficiency and redox disequilibrium leads to cachexia, immunological dysfunction in both AIDS and cancer. Toxic drugs perpetuate the problem of chronic thiol depletion and redox dysfunction. Must read for anyone wanting a deep dive into biochemistry, the historical context of AIDS, and the major flaws in the existing dogma.5 people found this helpfulHelpfulComment Report abuse
📷Stephanie Seneff5.0 out of 5 stars If you think you understand AIDS and cancer, think again!Reviewed in the United States on October 26, 2012Verified PurchaseThis is arguably the best book I have ever read, in terms of how it spoke to me. The author obviously is extremely well informed about biology, and the book is full of detailed accounts of how biology works. The hypothesis he proposes is a mind-bender: he makes a strong claim that AIDS and cancer are caused by an excessive cumulative exposure to oxides of nitrogen, which results in a steady drain of glutathione and other sulfur-containing metabolites.It will also make you seriously question the validity of "standard treatment" for diseases like AIDS and cancer.
So we have a situation where the alternative hypothesis put forth in 1993 has continued to be developed on and proving itself more and more valuable as a useful assumption to treat patients diagnosed with both cancer and AIDS however, as the title of the book suggests, despite building such a robust hypothesis this powerful argument still exists as a silent revolution within the medical community as with half a trillion dollars of tax payer dollars diverted in to HIV related research over the last 30 years, who would be willing to declare the HIV/AIDS hypothesis as dead? And even if they did, how would they overcome the incumbent assumptions regarding the disease when even esteemed academics such as Duesberg get turned in to a complete pariah when the medical/scientific/publishing apparatus declares you a AIDS Denialist. How many books have to get published, academics have to speak up in order to declare a hypothesis invalid and begin diverting those tax payer dollars towards a new line of inquiry which may in fact yield much more beneficial findings for global health?

THE OUT OF AFRICA THEORY

How was the Out of Africa Theory Established?
Out of Africa was only established in the 90’s during a debate as to the age of modern humans.
The development of genetic analysis tools in the 1980s helped scientists grow attracted to the out of Africa hypothesis. Matches between the DNA of living modern humans and fossil remains verified that H. sapiens evolved several hundred thousand years ago on African soil.
The theory explains that while numerous human-like species walked the planet, only one arose into modern man*.*

From wiki:
"There were at least several "out-of-Africa" dispersals of modern humans, possibly beginning as early as 270,000 years ago, including 215,000 years ago to at least Greece, and certainly via northern Africa about 130,000 to 115,000 years ago.These early waves appear to have mostly died out or retreated by 80,000 years ago.
The most significant "recent" wave took place about 70,000–50,000 years ago, via the so-called "Southern Route", spreading rapidly along the coast of Asia and reaching Australia by around 65,000–50,000 years ago,"
The Out of Africa Theory Has No Home
Accordingly, we can infer that Eve lived three times 50,000 to 60,000 years ago, or roughly 150,000 to 180,000 years ago.5
This declaration was regarded as the final word, and the resolution of "15 years of disagreement"6 between two branches of science. Wilson and Cann triumphantly proclaimed victory on behalf of the molecular geneticists declaring that "we won the argument, when the palaeontologists admitted we had been right and they had been wrong."7
With the case closed and bragging rights secured in perpetuity, science had once again provided certainty and an African ancestry. Or so it seemed. But not long after their paper was published Rebecca Cann realised they were mistaken. In 1982 she examined the mitochondrial DNA of 112 Indigenous people, including twelve full-descent Aboriginals, and the results were in total opposition to what they assumed was fully resolved.
Nevertheless, Cann was obliged to contradict a central tenet of their paper, stating that "mitochondrial DNA puts the origin of Homo sapiens much further back and indicates that the Australian Aboriginals arose 400,000 years ago from two distinct lineages,
The realignment and reversals were of immediate concern to Alan Wilson. If Cann was correct in detecting a "much higher number of mutations"11 they may as well tear up their original paper.
.......Upon receiving the results of his second mtDNA sampling Wilson immediately conceded the Out-of-Africa theory was wrong.......
Referring back to Wilson and Canns original calculations, their proposed timing of somewhere between 50-60,000 years stands on no less shaky ground than their genetic miscalculation. There are at least ten Australian sites claimed to be older than 60,000 years, granted every date is challenged by conservative critics, but even so, all are the products of respected academics.
What needs to be accepted is that if just one date proves to be correct, irrespective of whatever judgment is passed on the other nine, it can be confidently declared as a fact that Australia was not settled by African Homo sapiens 60,000 years ago. Whether the winning site turns out to be Lake George-fire-stick farming (120,000 years); Lake Eyre-skullcap (135,000 years); Jinmium-tools (176,000 years); Panaramittee-rock-engraving of saltwater crocodile (75,000 years); Rottnest Island-tools (70,000 years); Devonport-rock-engravings (>115,000 years); Jinmium-art (75-116,000 years); Great Barrier Reef-fire-stick farming (185,000 years); Lake Mungo (WLH3)-complete skeleton (61-65,000 years); or (WLH1)-cremated bones (61,000 years); one out of the ten is sufficient to deny African entry.
http://nationalunitygovernment.org/content/first-race-out-australia-not-africa-0

BIOLOGICAL LAWS

The main reason I structured this post the way I have is to emphasise the explanatory power of the different explanations for causation in a couple of controversial topics and how some hypotheses are favoured more than others in incumbent organisations which may have a conflict of interest in perpetuating the misunderstanding. In admitting the failure of the HIV AIDS hypothesis you are slaughtering a half a trillion tax payer dollar cash cow that's been paying your way for the last few decades. To accept the out of Australia theory over the out of Africa could similarly challenge the human ape common ancestor narrative as well.
A Law on the other hand, is something that is always the case. The Laws of thermodynamics can not be violated. There may be phenomena where there appears to be some violations as temporal oppositions but when seen nested within hierarchical systems do in fact adhere to these laws. In terms of Biology there are only a few listed on wikipedia as
https://en.wikipedia.org/wiki/Biological_rules
There are definitely a few interesting ones there that warrant further contemplation particularly with respect to temperatures and latitudes however, it may be worth considering if there are any biological laws that haven't been included in this wiki list. However what about the biological laws proposed by Dr Ryke Geerd Hamer?
Dr. med. Ryke Geerd Hamer was born on May 17, 1935 in Mettmann, Germany. He spent his childhood with his paternal grandparents in East Frisia. In 1953, he began to study medicine, theology, and physics at the University of Tuebingen. At the age of 22, he completed his master's degree in theology and then, four years later, received his professional license as a doctor of medicine. The following years he practiced at various university clinics in Germany.
In 1972, Dr. Hamer completed his specialization in internal medicine and began to work at the University clinic in Tuebingen as an internist in charge of cancer patients. At the same time, he ran a private practice with his wife Dr. Sigrid Hamer, whom he had met during their studies in Tuebingen. He also showed an extraordinary talent for inventing medical devices. Among others, he owns the patent for a non-traumatic scalpel (Hamer Scalpel) which cuts twenty times sharper than a razor blade, a special bone saw for plastic surgery, and a massage table that automatically adjusts to the body's contours.
His inventions provided Dr. Hamer and his family with the financial means to move to Italy, where he realized his plan to treat the sick in the slums of Rome free of charge. On August 18th, 1978, while in Rome, the Hamers received the shocking news that their son Dirk had been accidentally shot by the Italian Prince Victor Emanuel of Savoy. On December 7th, 1978, Dirk succumbed to the injuries and died in his father's arms. Dirk is buried under the city wall at the pyramid in Rome.
Shortly after Dirk's death, Dr. Hamer was diagnosed with testicular cancer. Since he had never been seriously ill, he postulated that the development of his cancer could be directly related to the unexpected loss of his son. In fact, he would eventually, in honor of Dirk, call this unexpected shock a DHS or “Dirk Hamer Syndrome”. Dirk's death and his own experience with cancer set Dr. Hamer on an extraordinary scientific journey.
At the time head internist of a cancer clinic at the University of Munich, he began to investigate his cancer patients' histories and soon learned that, like him, they all had experienced an unexpected shock of one sort or another. But he took his research even further. Pursuing the hypothesis that all bodily processes are controlled from the brain, he analyzed his patients' brain scans and compared them with their medical records and personal histories. To his amazement, he found a clear correlation between certain types of “conflict shocks”, how these shocks manifest themselves on the organ level as specific symptoms and how all this is connected to the brain. Until then, no studies had examined the role of the brain as the mediator between the psyche and a diseased organ.
Dr. Hamer established that every disease originates from a shock or trauma that catches an individual completely by surprise. The moment the unexpected conflict occurs, the shock strikes a specific, predetermined area in the brain causing a lesion (later called Hamer Focus or HH - Hamerscher Herd), visible on a brain scan as a set of sharp concentric rings. Before Dr. Hamer identified these ringed lesions on a brain scan, radiologists considered them as artifacts created by a glitch in the machine. But Siemens, a manufacturer of computer tomography equipment, certified that these target lesions cannot be artifacts because even when the tomography is repeated and taken from different angles, the same ring formation always appears in the same location.
The brain cells that receive the shock (DHS) send a biochemical signal to the corresponding body cells causing the growth of a tumor, a meltdown of tissue, or functional loss, depending on which part of the brain is involved. The reason why specific conflicts are irrefutably tied to specific areas in the brain is that during the development of the human organism each brain area was programmed to respond instantly to situations that could threaten survival. While the brainstem, the oldest part of the brain, is programmed with primordial conflicts related to breathing (death-fright conflicts) reproduction (procreation conflicts) and food (morsel conflicts), the cerebrum, the youngest part of the brain, correlates to more advanced matters (separation conflicts, territorial conflicts). Dr. Hamer also discovered that every disease progresses in two phases: first, a conflict-active phase, characterized by emotional distress, a lack of appetite, and sleeplessness, and then, provided the conflict can be resolved, a healing phase. This is the period in which the psyche, the brain and the affected organ undergo the phase of recovery, an often difficult process marked by fatigue, headaches, inflammation, “infections”, and pain.
Firmly anchored in the science of embryology and in full accordance with evolutionary logic, Dr. Hamer called his findings “The Five Biological Laws of the New Medicine”. Over the years, he was able to confirm his discoveries with over 40,000 case studies.
https://learninggnm.com/SBS/documents/verifications.html
https://learninggnm.com/SBS/documents/five_laws.html

FIRST BIOLOGICAL LAW (“The Iron Rule of Cancer”)

1st Criterion: Every “disease” - hereinafter called Significant Biological Special Program (SBS) - originates from a DHS (Dirk Hamer Syndrome), which is an unexpected, highly acute, and isolating conflict shock that occurs simultaneously in the psyche, the brain, and on the corresponding organ.2nd Criterion: The content of the conflict determines which organ will be affected and from which area of the brain the SBS will be controlled. 3rd Criterion: Every SBS runs synchronously on the level of the psyche, the brain, and the organ.
Severe malnutrition, poisoning, or an injury can result in the dysfunction of an organ without a DHS.

SECOND BIOLOGICAL LAW

Every SBS-Significant Biological Special Program runs in two phases provided there is a resolution of the conflict.
THE CONFLICT-ACTIVE PHASE (CA-Phase)
When the DHS occurs, the normal day-night-rhythm is instantly interrupted and the autonomic nervous system switches into lasting sympathicotonia and a prolonged state of stress with nervous restlessness, a fast heartbeat, elevated blood pressure, slow digestion, frequent urination, and little appetite. Since the blood vessels are constricted during stress, typical signs of conflict activity are cold hands, cold sweats, and the shivers. We therefore call the conflict-active phase also the COLD phase.
The PSYCHE is in a compulsive thinking mode. The constant dwelling over the conflict causes sleep disturbances (waking up shortly after falling asleep, usually around 3 o’clock in the morning). The extra waking hours and the total focus on the conflict serve to find a resolution to the conflict as soon as possible.
THE HEALING PHASE (PCL= post-conflictolysis)
With the resolution of the conflict, the autonomic nervous system switches into lasting vagotonia and a prolonged state of rest with fatigue but good appetite. Resting and the desire to eat provide the organism with the necessary energy for healing. If the healing phase is intense, the tiredness could be so overwhelming that one can hardly get out of bed. The need for sleep is particularly strong during the day (in conventional medicine, persistent tiredness is diagnosed as “chronic fatigue syndrome”). Accompanying symptoms are a slow pulse and low blood pressure. During vagotonia, the blood vessels expand causing warm hands and a warm skin. We therefore call the healing phase also the WARM phase.
The PSYCHE is in a state of relief.
If more tissue is required to facilitate a conflict resolution, the corresponding organ generates cell proliferation during the conflict-active phase. This process applies to all organs and tissues that are controlled by the brainstem and the cerebellum such as the lungs, liver, pancreas, colon, thyroid, or breast glands. In embryological terms, these organs derive from the endoderm or from the old mesoderm (see Third Biological Law).
If less tissue is required to facilitate a conflict resolution, the organ or tissue responds with cell loss. This process applies to all organs and tissues that are controlled from the cerebral medulla and the cerebral cortex such as the bones and joints, ovaries, testicles, coronary arteries, coronary veins, cervix, bronchi, larynx, and the skin. In embryological terms, these organs derive from the new mesoderm or from the ectoderm (see Third Biological Law
Diagram of the Two Phases
A “hanging healing” refers to the situation where the healing phase cannot be completed because of recurrent conflict relapses.

THIRD BIOLOGICAL LAW


Dr. Hamer's medical research is firmly anchored in the science of embryology. Taking into account the development of the fetus (ontogenesis) he discovered that the correlation between the psyche, the brain, and the organs is closely connected to the three embryonic germ layers (endoderm, mesoderm, ectoderm) from which all organs of the human body originate. The Third Biological Law shows that the location of the Hamer Focus in the brain as well as the cell proliferation or cell loss following a DHS are not accidental but part of a meaningful biological system inherent in every living organism. The Biological Special Programs of Nature are encoded in every human cell and thus inscribed in the DNA, the carrier of genetic information (see GNM Article “Understanding Genetic Diseases”).
Through analyzing and comparing thousands of brain scans Dr. Hamer found that organs originating from the same embryonic germ layer are controlled from the same part of the brain.

  • All organs that derive from the endoderm are controlled from the brainstem. Primitive life forms such as bacteria have only endodermal functions.
  • All organs that derive from the old mesoderm are controlled from the cerebellum.
  • All organs that derive from the new mesoderm are controlled from the cerebral medulla.
  • All organs that derive from the ectoderm are controlled from the cerebral cortex.

FOURTH BIOLOGICAL LAW

For the first 2.5 billion years, microbes were the only organisms inhabiting the earth. Gradually, they populated other life forms, including plants, animals, and humans. It is estimated that the number of microbial cells residing in the human body (known as the “human microbiome”) outnumbers the body cells almost 4 to 1. Owing to their symbiotic relationship with the human organism and their vital role in maintaining the body tissues, microbes have become indispensable for our survival.
NOTE: The placenta that connects the developing fetus to the uterus is not sterile, as previously thought, but harbors a rich collection of bacteria. Hence, bacteria assist the healing process already in the organism of the fetus! “For more than a century scientists have assumed that babies come into the world germ-free after nine months in a sterile womb. Not so, new studies find: Bacteria lurk in the placenta, amniotic fluid and umbilical cord, making the womb a germy place.” (Science News, May 28, 2014; see also "The Placenta Harbors a Unique Microbiome", Science Transational Medicine, May 21, 2014). Mycobacteria such as TB bacteria are also introduced to the newborn through the breast milk.
The theory that certain “diseases” are caused by “pathogenic microbes” is one of the most persistent doctrines of modern medicine. This general conception is largely attributable to the fact that microbes are present at the site of a “diseased” organ. And since the activity of microbes is accompanied by swelling, fever, inflammation, pus, discharge, and pain, microbes are believed to be the cause of “infectious diseases”. Similar to the idea that an “abnormal” growth of cancer cells leads to the development of a “malignant” tumor, it is wrongly assumed that microbes growing beyond their normal ranges (see immune system theory) results in virulent “infections”.
Microbes don’t cause diseases but play instead a vital role during the healing phase.
The Fourth Biological Law shows that so-called “infectious diseases” occur exclusively in the second phase of a Biological Special Program, where the organism uses the microbes to optimize healing. During their activities microbes require a warm environment, hence, the development of an inflammation and fever. Microbes also need an acidic milieu, which is suitably provided through the vagotonic state that is dominant in every healing phase. The onset of an “infection” is therefore not, as presumed, brought on by an imbalanced pH level (a “wrong diet”) but rather by the transition from the conflict-active phase into the healing phase.
NOTE: Microbes are endemic. They live in harmony with all organisms of the ecological milieu in which they have developed over millions of years. Contact with microbes that are foreign to the human body, for example through traveling abroad, does not cause per se a “disease”. However, if, let’s say, a European happens to resolve a particular conflict in the tropics and comes in contact with local microbes, the related organ will use them for the healing process. Since the body is not accustomed to these exotic microorganisms, the healing symptoms can be quite severe.

Diseases are not contagious!
If two or more people happen to have the same symptoms, for example, a cold, diarrhea, or a stomach flu, this means that all of them are in the healing phase of the same type of conflict (stink conflict, indigestible morsel conflict, territorial anger conflict) that took place, let’s say, at school, at home, or at work.

FIFTH BIOLOGICAL LAW - THE QUINTESSENCE

Every so-called disease is part of a Significant Biological Special Program of Nature created to assists an organism (humans and animals alike) during unexpected distress.
Dr. Hamer: “All so-called diseases have a special biological meaning. While we used to regard Mother Nature as fallible and had the audacity to believe that She constantly made mistakes and caused breakdowns (malignant, senseless, degenerative cancerous growths, etc.) we can now see, as the scales fall from our eyes, that it was our ignorance and pride that were and are the only foolishness in our cosmos. Blinded, we brought upon ourselves this senseless, soulless and brutal medicine. Full of wonder, we can now understand for the first time that Nature is orderly and that every occurrence in Nature is meaningful, even in the framework of the whole. Nothing in Nature is meaningless, malignant or diseased.”

WHY AREN'T THESE LAWS IN WIKIPEDIA?

In October 1981, Dr. Hamer submitted his research to the University of Tuebingen as a post-doctoral thesis. The objective was to have his findings tested on equivalent cases so that the New Medicine could be taught to all medical students and that patients could benefit from the discoveries as soon as possible. But to his great surprise, the University committee rejected his work and refused to evaluate his thesis. This is an unprecedented case in the history of universities! There was yet another surprise. Shortly after he had handed in his thesis, Dr. Hamer was given the ultimatum to either deny his findings or his contract would not be renewed. It was extremely difficult for him to understand why he was being expelled from the clinic for presenting well-substantiated scientific findings. Dr. Hamer stood his ground. After his dismissal, he retreated to his private practice where he continued his research. Several attempts to open a private clinic failed because of concerted efforts opposing it. Letters of Dr. Hamer's patients to health officials remained unanswered or were returned with the comment: “Not applicable!”. To this day, the firm position of the authorities has not changed.
The harassment of Dr. Hamer culminated in 1989, when a court sentence stopped him from practicing medicine. Despite the fact that his scientific work had never been disproved, he lost, at the age of 54, his medical license on the grounds that he refused to renounce his findings on the origin of cancer and to conform to the principles of official medicine. Deprived of a medical license, Dr. Hamer now relied on other doctors to obtain brain scans and patients' records. But he was determined to continue his work. By 1987 Dr. Hamer had already analyzed over 10,000 cases and was able to expand his discovery of the Five Biological Laws to practically all diseases known in medicine. Meanwhile, the press and the medical establishment stopped at nothing to attack him and his work. Tabloid journalists and medical “experts” portray Dr. Hamer as a charlatan, a self-proclaimed miracle healer, a cult leader, an irrational outsider, or an insane criminal who denies cancer patients the ‘life-saving’ conventional treatments.
In 1997, Dr. Hamer was arrested and sentenced to 19 months in prison for having given three people free medical information without a medical license. By contrast, in 1991, thirteen years after he had killed Dirk Hamer, Victor Emanuel of Savoy had been sentenced to a mere 6 months probation for the illegal possession of a weapon. When Dr. Hamer was arrested, the police searched his patient files. Subsequently, one public prosecutor was forced to admit during the trial that after more than five years, of 6500 patients with mostly ‘terminal’ cancer, 6000 were still alive. And so, ironically, it was his opponents that provided the actual statistics attesting to German New Medicine's remarkable success rate. Yet, to this day, the University of Tuebingen refuses, despite court orders in 1986 and 1994, to test Dr. Hamer's scientific work. Similarly, official medicine refuses to endorse GNM despite its numerous verifications by both physicians and professorial associations.


submitted by whipnil to C_S_T [link] [comments]


2020.09.06 01:07 rationalprolifer The definition of organism

The pro-life view often relies on the idea that the unborn are organisms from the moment of conception. But what is an organism? How do we distinguish human organisms (like an embryo or fetus) from mere human cells (like a gamete or tumor)?
Maureen Condic helps us answer these questions in her most recent book, Untangling Twinning. The first chapter of her book discusses when human life begins and can be viewed here for free, but I’ll also excerpt it down below:
The Origin of New Cells
In considering the question of when the life of a new human being commences, we must first address the more fundamental question of when a new cell, distinct from sperm and egg, comes into existence. Human cells can be distinguished from each other by scientific criteria. Indeed, the entire field of biology is based on the ability of scientists to distinguish one cell type from another. For example, skin cells can be converted into pluripotent stem cells by manipulation of specific genes during cellular reprogramming,1 but this is clearly a conversion of one cell type to another. No credible scientist would argue that skin cells are already pluripotent stem cells or are the equivalents of pluripotent stem cells. These are two distinct cell types with distinct properties. The fact that one cell type can give rise to a different cell type in no way alters the fact that a new cell type has been produced.
How do scientists determine when a new cell type has been produced, either in the laboratory or as a consequence of a natural biologic process? The scientific basis for distinguishing one cell type from another rests on two criteria: differences in molecular composition and differences in cell behavior.[2] Differences in molecular composition can arise due to an alteration in gene expression, a change in the subcellular localization of existing molecules, or a chemical modification of existing molecules. Alternatively, when cells exhibit new behavior, for example, going from a stationary to an actively migratory state, they can also be identified as distinct cell types. In many cases, changes in composition directly cause changes in behavior. Importantly, the criteria for when a new cell forms are based on scientific observations (not mere opinion or speculation): observations that are employed throughout the scientific enterprise and that can be independently verified.
Based on these criteria, the fusion of sperm and egg clearly produces a new cell type. Following the binding of sperm and egg to each other, the membranes of these two cells fuse, creating a single hybrid cell: the zygote or one-cell embryo.3 Cell membrane fusion is a well-studied and very rapid event, occurring in less than a second.4 Because the zygote arises from the fusion of two different cells, it contains all the components of both sperm and egg, and therefore the zygote has a unique molecular composition that is distinct from either gamete.
Subsequent to sperm-egg fusion, events rapidly occur in the zygote that do not normally occur in either sperm or egg.5 Within seconds, the zygote initiates a molecular cascade that will, over the next thirty minutes, result in chemical modifications that prevent additional sperm from binding to the cell-surface. Thus, the zygote acts immediately and specifically to antagonize the function of the gametes from which it is derived. The “goal” of both sperm and egg is to find each other and fuse. Yet the first act of the zygote is to prevent any further binding of sperm to the cell surface. Clearly, the prior trajectories of sperm and egg have been abandoned, and a new trajectory—that of the zygote—has taken their place.
Based on this factual description of the events following sperm-egg fusion, we can confidently conclude that a new cell (the zygote), distinct from the gametes giving rise to it, comes into existence at the scientifically well-defined “moment” of sperm-egg fusion.
The conclusion that sperm-egg fusion creates a new cell has been questioned by Eugene Mills,6 who argues that subsequent to sperm-egg fusion, only a modified gamete, or “fertilized egg” exists, with eggs and fertilized-eggs being ontologically “identical.” Mills’s position has been effectively rebutted by Calum Miller and Alexander Pruss,7 who argue that (1) it is not sufficient to claim identity of the zygote and the oocyte based on the fact that the word “egg” is at times used to describe both entities, (2) the fact that at sperm-egg fusion an oocyte appears to persist when viewed with light microscopy is insufficient to reveal the many relevant changes that occur at a submicroscopic level, and finally, (3) there is no category other than an uninformative and nondiscriminating gross category such as “thing” or “cell” (a “coarse-grained chunk of matter”8) that can define an oocyte and a zygote as identical—categories that would also define as “identical” a living human and the corpse of that individual after death. Based on the argument of Miller and Pruss as well as on the criteria used by the scientific community to distinguish different cell types, the phrase “fertilized egg” is clearly not a valid scientific term, and the conclusion that sperm-egg fusion produces a new kind of living human cell is warranted. Yet the important question of what kind of cell is produced by this event remains to be addressed.
What Kind of Cell is Produced by Sperm-Egg Fusion?
What is the nature of the new cell that comes into existence upon sperm-egg fusion? Most importantly, is the zygote a new human individual or, as Grobstein maintained, merely a human cell that will eventually give rise to a new human individual—that is, a “preembryo”? Both human cells and human organisms are alive, exhibiting characteristics that are uniquely observed in living entities, such as autonomy, integration, and reproduction.9 Yet just as science distinguishes between different types of cells, it also clearly distinguishes between human cells that are parts of an integrated organism and whole human organisms.
An organism is defined as “(1) a complex structure of interdependent and subordinate elements whose relations and properties are largely determined by their function in the whole and (2) an individual constituted to carry on the activities of life by means of organs separate in function but mutually dependent: a living being.”10 Based on this definition, the interaction of parts in support of an integrated whole is the distinguishing feature of an organism. Because organisms are “living beings,” another name for a human organism is a “human being.”
Human organisms have a number of traits that distinguish them from human cells. First, humans, and all multicellular organisms, undergo development—that is, an orderly sequence of maturation that results in a characteristic adult form. In contrast, cells may proliferate to produce copies of themselves or may generate tumors that contain many different cell types, but they will not produce a characteristic sequence of events that robustly results in the generation of a species-specific mature state. Development is the defining characteristic of all embryos from the zygote stage onward.[11]
A second characteristic of organisms is their ability to repair injury to restore the health and function of the entity as a whole. Embryos are quite remarkable in their ability to recover from even catastrophic injury. For example, when IVF-produced embryos are subjected to preimplantation genetic diagnosis, one cell is removed at the eight-cell stage. Surprisingly, in many cases, the embryo will regenerate the missing parts and proceed with normal development.12 In contrast, when portions of tumors are removed, the remaining cells will continue to proliferate, but will not specifically regenerate the damaged structures or restore the original state.
A third characteristic of organisms is adaptation to changing environmental circumstances, such that the health and overall function of the organism is preserved. A striking example of embryo adaptation is ectopic implantation. In most cases, implantation outside of the uterus is not compatible with life; embryos typically fail to establish an adequate placental circulation with the mother and subsequently die. There are cases, however, where healthy, term infants have been delivered after implanting in their mother’s ovary,13 abdomen,14 or liver,15 indicating that embryos can adapt to highly abnormal environments and continue to mature normally.
Finally, at all stages of the life span, organisms show integrated function of parts to promote the health of the organism as a whole. Within minutes of sperm-egg fusion, the zygote initiates a specific molecular cascade, using elements derived from both sperm and egg, to direct its subsequent maturation.16 Substantial evidence indicates that by the four-cell stage (or earlier[17]), individual blastomeres have distinct patterns of gene expression,18 different cellular functions,19 and unique developmental capabilities.20 This indicates that the integrated function of the embryo as a whole reflects collaboration of its parts to generate a normal developmental sequence. While all cells are capable of short-range cell-cell communication, only embryos establish a global pattern of interaction that benefits the entity as a whole. Indeed, within the first minutes and days of life, the embryo initiates dozens of distinct, globally integrated events that are critical for its survival and healthy maturation.21
Based on this scientific description of fertilization and subsequent embryonic development, sperm-egg fusion clearly generates a new human cell, the zygote, with composition and behavior that are distinct from that of either gamete. Moreover, the zygote is not merely a unique human cell, but a cell with all the properties of a fully complete (albeit immature) human organism; it is “an individual constituted to carry on the activities of life by means of organs separate in function but mutually dependent: a living being.”
This understanding of the embryo provides the foundation for a broader view of what it means to be human. As human organisms, we respond to our environment in a manner that maintains the survival and health of our bodies as a whole. This integrated function and “wholeness” are intrinsic to our nature and are the basis for any ethical view of human beings, as distinct from human cells. The facts of human embryology outlined here allow us to establish a first unifying concept for consideration of the human embryo:
UNIFYING CONCEPT 1: Based on objective, scientific criteria, the life of an individual human being unambiguously begins at sperm-egg fusion.
Footnotes:
1 Takahashi et al., “Induction of Pluripotent Stem Cells.”
2 A minor caveat to this conclusion involves cyclic or transient changes in cell composition/behavior that are followed by a return to the initial cellular state (for example, molecular changes associated with the mitotic cycle or in response to a chemical signal). Such changes do not signify the formation of a new cell, but rather entry of a cell into a specific, transient, cellular state.
3 Satouh et al., “Visualization of the Moment.”
4 Hernández and Podbilewicz, “Hallmarks”; Aguilar et al., “Genetic Basis”; Risselada and Grubmüller, “How SNARE Molecules Mediate”; Marsden, Tomatsu, and Kros, “Model Systems.”
5 Condic, “When Does Human Life Begin? The Scientific Evidence”; Condic, “When Does Human Life Begin? A Scientific Perspective.”
6 Mills, “Egg and I.”
7 Miller and Pruss, “Human Organisms.”
8 Miller and Pruss, “Human Organisms,” 537.
9 Rosslenbroich, “Properties of Life.”
10 Merriam Webster Medical Dictionary.
11 Condic, “Totipotency.” For a discussion of cases in which development does not occur, see Chapter 3 in this volume.
12 Harper and Sengupta, “Preimplantation Genetic Diagnosis.”
13 Huang et al., “Primary Unruptured”; Sehgal et al., “Full Term Ovarian Pregnancy.”
14 Dahab et al., “Full-Term Extrauterine”; Isah et al., “Abdominal Pregnancy”; Zhang and Sheng, “Full-Term Abdominal Pregnancy”; Xiao et al., “Abdominal Pregnancy”; Badria et al., “Full-Term Viable.”
15 Shukla et al., “Primary Hepatic Pregnancy.”
16 Condic, “When Does Human Life Begin? The Scientific Evidence”; Condic, “When Does Human Life Begin? A Scientific Perspective.”
17 Recent evidence suggests that differences in gene expression and developmental capabilities occur as early as the two cell stage; see Casser et al., “Retrospective Analysis”; Casser et al., “Totipotency Segregates.”
18 Antczak and Blerkom, “Oocyte Influences”; Edwards and Hansis, “Initial Differentiation”; Hansis, Grifo, and Krey, “Candidate Lineage Marker”; Jędrusik et al., “Role of Cdx2”; Sun et al., “Differential Expression”; Plachta et al., “Oct4 Kinetics.”
19 Torres-Padilla et al., “Histone Arginine Methylation”; Hupalowska et al., “CARM1 and Paraspeckles”; Wang et al., “Asymmetric Expression.”
20 Piotrowska-Nitsche et al., “Four-Cell Stage”; Jędrusik et al., “Role of Cdx2.”
21 Condic, “When Does Human Life Begin? The Scientific Evidence.”
submitted by rationalprolifer to prolife [link] [comments]


2020.09.04 07:38 QUILTED_NORTHERN_TP BRTXQ--the argument for me to GTFO and sell

I've sunken $12K into BRTXQ so far and have lost $5400 of that. I got in solely because of my interest in the company as a patient, and my knowledge that their stem cell product works, and when I discovered the incredible buzz surrounding the stock the last few weeks, I wanted to profit from it. But now I'm sadly realizing that I don't know enough about this, and probably have no business trading in these amounts. When I decided to get in, I took my amateurism and lack of knowledge into consideration, but at the time it felt like a no-brainer and that the stock couldn't go down. Unfortunately, my initial on-paper logic has turned out to be spot on.
I have a net worth (post-losses) of about $70K. I need tens of thousands of dollars for a stem cell treatment for my joints in the near future. I would hurt that goal very badly to lose that whole $12K.
The argument to hold:
  • I know their stem cell product is medically legit.
  • They MAY come out of bankruptcy successfully in the near future, so the stock might have upside from here.
The argument to sell:
  • I don't have enough time to do as much DD as I need to, and never did.
  • I bought based on false assumptions about the upside. I did not realize the collapse in stock price has been largely, if not entirely a result of massive dilution over the last few year. In March 2018, the market cap was all of about $9.5M ( https://last10k.com/sec-filings/brtx#link_fullReport). It's now worth over three times that. Hence its pre-bankruptcy stock prices are not valid benchmarks. Even if the company gets a favorable court ruling, I have no idea where it goes.
  • I don't know enough to judge the company on its commercial viability.
    • I don't know enough about bankruptcy to judge the likelihood of a favorable outcome in the upcoming court proceedings. I don't understand the significance of JD's objection. Other anonymous people on the internet say it's going to go in our favor, but what if these people don't know what they're talking about, either?
    • While I believe in the product, this in itself does not justify believing in the company. By their own admission, they face huge commercial risks. The fact that the product works does not mean they can raise enough funds to get FDA approval, or that they will be able to sell it successfully in today's fucked up healthcare system.
  • I have noticed strong signs of a pump and dump scam. Accounts on here, Twitter, and iHub appeared out of nowhere in August to do nothing but hype BRTXQ. Reddit's primary advocate, Mammoth_package, is now quiet. Other voices who have been bullish just seem not to really know much more than I do. People are just pulling figures out their asses about where they think the stock is going. 0.1? 0.5? 1.0? Really? Based on WHAT?
  • I really don't need to lose the $6600 I have left.
While I want to hold and for it to work out, rationality tells me I should cut my losses and get out.
In this moment I can either choose to take $6600 cash, or hold an asset that MAY turn out to be worth more in a few months years, but which could just as easily go down, and I have no ability to tell which is going to happen. I must decide before another bloodbath happens tomorrow.
submitted by QUILTED_NORTHERN_TP to pennystocks [link] [comments]


2020.08.31 18:19 alus200314845 Healthy Pregnancy

Healthy Pregnancy
Every woman wants to enjoy a issueless pregnancy. The best thing that will make you and your growing baby happy and healthy is to eat healthy and take care of yourself.

Nutrition

Amazing things happen inside your uterus. In the first few months of your pregnancy, your baby's spine, organs and support systems develop; In addition, your baby needs a diet rich in protein, calcium, vitamins and minerals to develop. These are the things you should eat and stay away from during your pregnancy.
Healthy Pregnancy

How Much Should I Eat?

Contrary to common belief, there is no need to 'eat for two people' during pregnancy. You only need an additional 200 to 250 calories, which is only valid for the last three months. If you continue to feed as usual during your pregnancy, it will be easier to return to your normal weight after birth. Towards the end of your pregnancy, you may be less hungry than usual. This is because the fetus presses on your stomach so you won't want to eat that much.

Which Foods Should Be Avoided?

It is good to avoid some foods during pregnancy. These include moldy-ripe soft cheeses such as Camembert and Brie, which are at risk of carrying Listeria and Gorgonzola (Italian moldy cheese) and Roquefort blue-veined cheeses. You should avoid raw or undercooked meat, raw eggs and sushi, as they may contain salmonella. Pregnant women are also advised to stay away from swordfish meat and shellfish due to the risk of bacteria in it, as they contain high amounts of mercury.

Cause Nausea in the Morning?

Two out of three women experience nausea in the first 16 weeks of pregnancy. Although it can be experienced at any time of the day, nausea is generally more severe in waking up from the first sleep. To soothe your stomach, try eating toast next to tea before getting out of bed. If you're not lucky enough to have someone bring you breakfast, have some crackers next to your bed. Eat less and eat small snacks frequently throughout the day; Avoid fatty and spicy foods. Nausea in the morning will not hurt you or your baby, but if you can't keep anything in your stomach, you should consult your family doctor.

Why Does Occur Craving?

The cause of craving is not completely known. Many women notice that their sense of taste and smell changed during pregnancy. For example, some women feel a strange metallic taste in their mouths quite early in pregnancy (this may be the first symptoms of pregnancy for an 'experienced' mother!), Others feel that their sense of fullness in the nose is blunted by their sense of taste and smell. These changes can also affect the foods they love and dislike.

Which Vitamins Should Be Consumed?

There are many vitamins that will help you and your growing baby:
- Folic acid: Our body needs folate vitamin (folic acid) to produce new cells. Since our bodies cannot store them, we need fresh fortifications regularly to stay healthy. Many foods contain folic acid, including spinach, sprouts, broccoli, green beans and potatoes. Some breads and cereals are also folic acid fortification. Especially pregnant women need good folic acid fortifications: Even if you are eating well, it is recommended to take 400 micrograms of folic acid per day. Folic acid is essential for the development of the embryo and reduces the risk of your baby being born with a spinal cord problem such as spinabifida. You should start taking folic acid fortifications as soon as you start trying to have a baby. If pregnancy is not planned, start taking as soon as your pregnancy test result becomes positive and continue for the first 12 weeks of your pregnancy.
- Vitamin B complex: If you feel tired during the first and third trimester of your pregnancy, taking a vitamin B complex can increase your energy level and help your baby develop a healthy nervous system. The vitamin B complex also contains vitamin B12, along with iron (fe) and folic acid and helps keep hemoglobin concentrations in the blood at good levels. Although a mild type of anemia is common during pregnancy, it helps prevent anemia; This is not surprising when you think your body should produce an additional liter of blood.
- Vitamin A and beta carotene: Your growing baby needs vitamin A to develop healthy eyes, bones, teeth and skin. Be careful not to take too much, as excess vitamin A may damage the fetus. Vitamin A can often be found in the liver, so don't eat more than one serving a day. Try to take a beta carotene-based multivitamin fortification instead of vitamin A. Beta carotene helps your body produce vitamin A as much and as much as it needs; thereby reducing the likelihood of overdose.
- Vitamin C: It strengthens your immune system and encourages your body to digest the iron it needs during pregnancy.
- Vitamin E: It helps to maintain energy levels, health of cells and tissues and supports blood circulation.
- Vitamin D: Facilitates calcium absorption for strong bones and teeth.

Fluid Intake

Shouldn't Alcohol Be Used During Pregnancy?

For most of us, enjoying a glass of wine is one of life's pleasures. When you are pregnant or trying to have a baby, it is important to completely stop drinking alcohol, especially during the first weeks of pregnancy, when baby development is most susceptible. Although the risk of drinking occasionally is low, drinking regularly or overdoing can seriously damage baby development.

Is it harmful to Thamuria?

Can't hold your urine? Do not panic. The desire to urinate more often is a common symptom of pregnancy. Even if you are only a few weeks pregnant, you will feel the need to urinate more often due to the pressure of the growing uterus on the bladder.

Why Is There So Much Thirst During Pregnancy?

And you are more likely to urinate because you are often thirsty and constantly getting fluids! During pregnancy, you maintain the additional two to three liters of fluid your body needs to produce additional blood and amniotic fluid and to meet other requirements of pregnancy. Keep these fluid levels at the highest levels; drinking plenty of water prevents your skin from drying out as well as constipation and urinary tract infection.

What to Drink Other Than Water?

Stay away from fizzy drinks because they can cause bloating in your stomach. As an alternative to water; try drinking refreshing drinks, herbal teas, juices and milk. Limit the amount of tea and coffee you drink, because both contain caffeine and excessive consumption can damage your health.

What else should not be drunk?

Other than alcohol; you should also avoid drinking unpasteurized milk as it may contain bacteria such as Campylobacter, E. coli, Listeria or Salmonella. Finally, experts recommend limiting caffeine intake to 200 milligrams a day, so reduce tea and coffee and do not forget that energy drinks and sodas also often contain plenty of caffeine.

Exercise

As soon as your pregnancy test result is positive, you do not need to leave the exercises. Exercise can help you carry the weight you gain during pregnancy as it supports muscle elasticity, strength and endurance, prepares you for the physical difficulties of birth and makes it easier to get your form after birth. Being active can also reduce physical ailments such as back pain, constipation, fatigue and swelling in the hands and feet, and help restore your mood and sleep patterns.

Which Sports Types Should Be Avoided?

It is best to stay away from sports that you are likely to fall hard or fall unbalanced during pregnancy. These include horse riding, skiing, gymnastics and water skiing. In addition, most physicians and midwives recommend that you stop riding after the sixth month of pregnancy due to the risk of falling, even if you are an experienced driver. However, you can ride the exercise bike as many times as you want.

Which Sports are The Best Choice?

Walking, jogging, swimming, riding an exercise bike and birth exercises in water are considered safe exercises that can be done during pregnancy unless you overdo it. Yoga and pilates are useful as long as you find a licensed instructor who is experienced in training pregnant women.

Have a Good Sleep

Is it dangerous to sleep by lying on belly? If you normally lie on your belly, you do not need to change this for the first five or six months. Contrary to common belief, the uterus will not be crushed in this position. If you can still do it after six weeks, you can continue to lie on your belly. As your belly grows, you may find it more comfortable to lie down by placing a pillow under your knee for support.
As the baby arrives, you will not have time to rest, so take advantage of every opportunity to rest and immediately raise your feet. (this will reduce swelling in your legs!). If you have trouble sleeping, these tips will be helpful:
- Sleep in a quiet and tidy room. Do not leave untidiness or paper around.
- Do not drink any caffeine-containing drinks until three hours before going to sleep.
- Exercise can help you cope with stress; but don't do anything overly tiring before you go to sleep.
- Let the bedroom be reserved for sleeping only.
- Set a ritual before going to sleep: drink a glass of milk or take a hot shower.
What are the Symptoms of pregnancy
submitted by alus200314845 to u/alus200314845 [link] [comments]


2020.08.30 10:58 TehEpicDuckeh Revamp ideas for 1000pts budget T'au.

Background info:
I'm most likely going to be playing some games with friends / a bit more competitively at a FLGS. (1000pts for now).
Likely to compete with Indomitus box armies as well as some AdMech.
General plan:
Notes: -Due to corona, haven't found the time to play more than a bit of kill team.
Looking for advice on if there's other boxes preferable to buy, or different loadout choices. Used advice from previous post to reform it into 3 different ideas. (sorry if it's too long)
Pings: BroodingDeception , Ns2- , AngelusDefensor
Idea 1: 3x XV8 Commander, lower drone count. Use Breachers as half screen half close range fighting force, with the Commanders as flex focused on killing MEQ etc. A final cadre of Bodyguards are more dedicated anti-armour.
 
++ Patrol Detachment 0CP (T'au Empire) [54 PL, 5CP, 997pts] ++
 
+ Configuration +
 
Battle Size [6CP]: 2. Incursion (51-100 Total PL / 501-1000 Points)
 
Detachment CP
 
Sept Choice: Farsight Enclaves
 
Sept Choice: Farsight Enclaves
 
+ Stratagems +
 
Veteran Cadre (3 models) [-1CP]
 
+ HQ +
 
Commander in XV8 Crisis Battlesuit [7 PL, 154pts]: Advanced targeting system, 3x Cyclic ion blaster, XV8-02 Crisis Iridium battlesuit
 
Commander in XV8 Crisis Battlesuit [7 PL, 154pts]: Advanced targeting system, 3x Cyclic ion blaster, XV8-02 Crisis Iridium battlesuit
 
Commander in XV8 Crisis Battlesuit [7 PL, 144pts]: 2. Through Unity, Devastation, Advanced targeting system, 3x Cyclic ion blaster, Warlord
 
+ Troops +
 
Breacher Team [4 PL, 90pts]
. Fire Warrior Shas'ui: Pulse blaster, Pulse pistol
. 9x Fire Warrior w/ Pulse Pistol: 9x Photon grenades, 9x Pulse blaster, 9x Pulse pistol
 
Breacher Team [4 PL, 90pts]
. Fire Warrior Shas'ui: Pulse blaster, Pulse pistol
. 9x Fire Warrior w/ Pulse Pistol: 9x Photon grenades, 9x Pulse blaster, 9x Pulse pistol
 
Breacher Team [4 PL, 54pts]
. Fire Warrior Shas'ui: Pulse blaster, Pulse pistol
. 5x Fire Warrior w/ Pulse Pistol: 5x Photon grenades, 5x Pulse blaster, 5x Pulse pistol
 
+ Elites +
 
XV8 Crisis Bodyguards [13 PL, 171pts]: Veteran Cadre
. Crisis Bodyguard: 3x Plasma rifle
. Crisis Bodyguard: 3x Plasma rifle
. Crisis Bodyguard: 3x Plasma rifle
 
+ Fast Attack +
 
Tactical Drones [4 PL, 60pts]
. 2x MV1 Gun Drone: 4x Pulse carbine
. 4x MV7 Marker Drone: 4x Markerlight
 
Tactical Drones [4 PL, 80pts]
. 4x MV4 Shield Drone: 4x Shield generator
. 2x MV7 Marker Drone: 2x Markerlight
 
++ Total: [54 PL, 5CP, 997pts] ++
 
Created with BattleScribe
(this has some validation errors but afaik it's just a bit buggy)
Idea 2: Cut most drones, put a rear gunline of strike teams with fireblades, while crisis suits spearhead the front.
 
++ Battalion Detachment 0CP (T'au Empire) [51 PL, 6CP, 996pts] ++
 
+ Configuration +
 
Battle Size [6CP]: 2. Incursion (51-100 Total PL / 501-1000 Points)
 
Detachment CP
 
Gametype: Matched
 
Sept Choice: T'au Sept
 
+ HQ +
 
Cadre Fireblade [2 PL, 45pts]
 
Cadre Fireblade [2 PL, 45pts]
 
Commander in XV8 Crisis Battlesuit [7 PL, 154pts]: 2. Through Unity, Devastation, Advanced targeting system, 3x Cyclic ion blaster, Warlord, XV8-02 Crisis Iridium battlesuit
 
+ Troops +
 
Breacher Team [2 PL, 45pts]
. Fire Warrior Shas'ui: Pulse blaster, Pulse pistol
. 4x Fire Warrior w/ Pulse Pistol: 4x Photon grenades, 4x Pulse blaster, 4x Pulse pistol
 
Strike Team [4 PL, 90pts]
. Fire Warrior Shas'ui: Pulse pistol, Pulse rifle
. 9x Fire Warrior w/ Pulse Pistol + Pulse Rifle: 9x Photon grenades, 9x Pulse pistol, 9x Pulse rifle
 
Strike Team [4 PL, 90pts]
. Fire Warrior Shas'ui: Pulse pistol, Pulse rifle
. 9x Fire Warrior w/ Pulse Pistol + Pulse Rifle: 9x Photon grenades, 9x Pulse pistol, 9x Pulse rifle
 
Strike Team [4 PL, 90pts]
. Fire Warrior Shas'ui: Pulse pistol, Pulse rifle
. 9x Fire Warrior w/ Pulse Pistol + Pulse Rifle: 9x Photon grenades, 9x Pulse pistol, 9x Pulse rifle
 
+ Elites +
 
XV8 Crisis Battlesuits [24 PL, 387pts]: Cross-linked stabiliser jets
. Crisis Shas'ui: 2x Fusion blaster, Shield generator
. Crisis Shas'ui: Drone controller, 2x Fusion blaster
. Crisis Shas'ui: 3x Cyclic ion blaster
. Crisis Shas'ui: 3x Cyclic ion blaster
. Crisis Shas'vre: 3x Cyclic ion blaster
 
+ Fast Attack +
 
Tactical Drones [2 PL, 50pts]
. 2x MV1 Gun Drone: 4x Pulse carbine
. 2x MV4 Shield Drone: 2x Shield generator
 
++ Total: [51 PL, 6CP, 996pts] ++
 
Created with BattleScribe
Idea 3: More traditional drone spam for shielding, with a few breachers as screens etc. (this takes all the drones I would be able to build)
 
++ Battalion Detachment 0CP (T'au Empire) [51 PL, 6CP, 991pts] ++
 
+ Configuration +
 
Battle Size [6CP]: 2. Incursion (51-100 Total PL / 501-1000 Points)
 
Detachment CP
 
Gametype: Matched
 
Sept Choice: Show Sept Tenets rule
. Custom Sept: Advanced Power Cells, Hybridised Weaponry
 
+ HQ +
 
Cadre Fireblade [2 PL, 45pts]
 
Ethereal [3 PL, 60pts]: 2. Through Unity, Devastation, Honour blade, Hover drone, Warlord
 
+ Troops +
 
Breacher Team [5 PL, 110pts]: MV36 Guardian Drone
. Fire Warrior Shas'ui: Pulse blaster, Pulse pistol
. 9x Fire Warrior w/ Pulse Pistol: 9x Photon grenades, 9x Pulse blaster, 9x Pulse pistol
. MV1 Gun Drone
 
Breacher Team [5 PL, 110pts]: MV36 Guardian Drone
. Fire Warrior Shas'ui: Pulse blaster, Pulse pistol
. 9x Fire Warrior w/ Pulse Pistol: 9x Photon grenades, 9x Pulse blaster, 9x Pulse pistol
. MV1 Gun Drone
 
Breacher Team [4 PL, 90pts]
. Fire Warrior Shas'ui: Pulse blaster, Pulse pistol
. 9x Fire Warrior w/ Pulse Pistol: 9x Photon grenades, 9x Pulse blaster, 9x Pulse pistol
 
+ Elites +
 
XV8 Crisis Battlesuits [15 PL, 220pts]
. Crisis Shas'ui: 3x Flamer, XV8-02 Crisis Iridium battlesuit
. Crisis Shas'ui: 3x Flamer
. Crisis Shas'vre: 3x Flamer
. 3x MV4 Shield Drone: 3x Shield generator
. 3x MV7 Marker Drone: 3x Markerlight
 
XV8 Crisis Battlesuits [15 PL, 316pts]: Cross-linked stabiliser jets
. Crisis Shas'ui: 2x Cyclic ion blaster, Drone controller
. Crisis Shas'ui: 2x Cyclic ion blaster, Shield generator, XV8-02 Crisis Iridium battlesuit
. Crisis Shas'vre: 3x Cyclic ion blaster
. 3x MV4 Shield Drone: 3x Shield generator
. 3x MV7 Marker Drone: 3x Markerlight
 
+ Fast Attack +
 
Tactical Drones [2 PL, 40pts]
. 4x MV7 Marker Drone: 4x Markerlight
 
++ Total: [51 PL, 6CP, 991pts] ++
 
Created with BattleScribe
Once again, thank you all for the feedback :)
submitted by TehEpicDuckeh to WarhammerCompetitive [link] [comments]


How to filter data in a datagridview in visual studio (vb.net) CellEndEdit in DataGridview Get the Selected column and row from DataGrid in WPF - YouTube Getting Cell value from dataGridView using CellClick Event ... C# WPF Tutorial 17- Show database values in Table or ... Editing Operations DataGridview Control in WindowsForms part-2 Validation with RadGridView for WinForms C# Programming Tutorial - CellEndEdit & CellValidating

datagridview CellValidating EVENT problem - CodeProject

  1. How to filter data in a datagridview in visual studio (vb.net)
  2. CellEndEdit in DataGridview
  3. Get the Selected column and row from DataGrid in WPF - YouTube
  4. Getting Cell value from dataGridView using CellClick Event ...
  5. C# WPF Tutorial 17- Show database values in Table or ...
  6. Editing Operations DataGridview Control in WindowsForms part-2
  7. Validation with RadGridView for WinForms
  8. C# Programming Tutorial - CellEndEdit & CellValidating

In this Windows form tutorial, I will teach you How to get the cell value from dataGridView using c#. In this tutorial, i has an EDMX file. Apply LINQ expres... This video is a tutorial on how to filter data in a datagridview in visual studio 2013 (vb.net). Be sure to subscribe to our channel for more of these amazin... in this video i Explianed How to Perform Editing Operations within DataGridview control. In this video, you will learn how to use the event-based Validation functionality in RadGridView for WinForms. Learn how to use the CellValidating and RowValidating events to ensure user input is ... C# - How to get user entered data from datagridview to windows Insert, Update and Delete from DataGridView to sqlite WPF ,MySql Sql database WPF WPF. ★★★Top ... Today we finished up the adjust hours File folder by finishing up the Cell Validating and Then doing the database update in the Cell End Edit. VB.NET - Get Selected Row Values From DataGridView Into TextBox In VB.NET [ With Source Code ] - Duration: 4:22. 1BestCsharp blog 61,666 views In this WPF Tutorial I Will show you how to get columns of selected row in WPF DataGrid. First to bind the Grid With user Defined datatype i.e class. After t...